DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AnxB10 and Prnp

DIOPT Version :9

Sequence 1:	NP_001162804.1	Gene:	AnxB10 / 33019	FlyBaseID:	FBgn0000084	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	NP_001265185.1	Gene:	Prnp / 19122	MGIID:	97769	Length:	254	Species:	Mus musculus

Alignment Length:	78	Identity:	18/78 - (23%)
Similarity:	27/78 - (34%)	Gaps:	19/78 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 FGTDEQEIIDVLVGRSNQQRQTIKAVY--------EAEFERDLVD-DLKDEL------GGKFEDV 80
            ||.|.::    ...|.|..|...:..|        :..|..|.|: .:|...      |..|.:.
Mouse   140 FGNDWED----RYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITIKQHTVTTTTKGENFTET 200

  Fly    81 IVGLMMPPVEYLC 93
            .|.:|...||.:|
Mouse   201 DVKMMERVVEQMC 213

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AnxB10	NP_001162804.1	Annexin	19..84	CDD:278615	14/67 (21%)
		Annexin	91..156	CDD:278615	1/3 (33%)
		Annexin	176..241	CDD:278615
		Annexin	251..317	CDD:278615
Prnp	NP_001265185.1	Prion_bPrPp	1..28	CDD:288443
		PRP	23..241	CDD:197548	18/78 (23%)
		Interaction with GRB2, ERI3 and SYN1. /evidence=ECO:0000269\|PubMed:11571277	23..231		18/78 (23%)
		Interaction with ADGRG6. /evidence=ECO:0000269\|PubMed:27501152	23..38
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..104
		5 X 8 AA tandem repeats of P-H-G-G-G-W-G-Q	51..90
		Prion	133..252	CDD:278789	18/78 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10502
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100