DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AnxB10 and Anxa5

DIOPT Version :9

Sequence 1:	NP_001162804.1	Gene:	AnxB10 / 33019	FlyBaseID:	FBgn0000084	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	NP_033803.1	Gene:	Anxa5 / 11747	MGIID:	106008	Length:	319	Species:	Mus musculus

Alignment Length:	312	Identity:	146/312 - (46%)
Similarity:	199/312 - (63%)	Gaps:	2/312 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 TVKDAAPFDASQDAQVLRAAMKGFGTDEQEIIDVLVGRSNQQRQTIKAVYEAEFERDLVDDLKDE 72
            ||.|...||...||:|||.||||.||||..|:::|..|||.|||.|...::..|.||||||||.|
Mouse     6 TVTDFPGFDGRADAEVLRKAMKGLGTDEDSILNLLTSRSNAQRQEIAQEFKTLFGRDLVDDLKSE 70

  Fly    73 LGGKFEDVIVGLMMPPVEYLCKQLHAAMAGIGTEEATLVEILCTKTNEEMAQIVAVYEERYQRPL 137
            |.||||.:||.:|.|...|...:|..|:.|.||:|..|.||:.::|.||::.|..||||.|...|
Mouse    71 LTGKFEKLIVAMMKPSRLYDAYELKHALKGAGTDEKVLTEIIASRTPEELSAIKQVYEEEYGSNL 135

  Fly   138 AEQMCSETSGFFRRLLTLIVTGVRDGLDTPVDVGQAKEQAAQLYSAGEAKLGTDEEVFNRIMSHA 202
            .:.:..:|||:::|:|.:::...||. ||.:|..|.:..|..|:.|||.|.|||||.|..|....
Mouse   136 EDDVVGDTSGYYQRMLVVLLQANRDP-DTAIDDAQVELDAQALFQAGELKWGTDEEKFITIFGTR 199

  Fly   203 SFPQLRLVFEEYKVLSGQTIEQAIKHEMSDELHEAMMAIVECVQSPAAFFANRLYKAMNGAGTDD 267
            |...||.||::|..:||..||:.|..|.|..|.:.::|:|:.::|..|:.|..||.||.||||||
Mouse   200 SVSHLRRVFDKYMTISGFQIEETIDRETSGNLEQLLLAVVKSIRSIPAYLAETLYYAMKGAGTDD 264

  Fly   268 ATLIRIIVSRSEIDLETIKQEFERIYNRTLHSAVVDAETSGDYKRALTALLG 319
            .||||::||||||||..|::||.:.:..:|:| ::..:||||||:||..|.|
Mouse   265 HTLIRVVVSRSEIDLFNIRKEFRKNFATSLYS-MIKGDTSGDYKKALLLLCG 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AnxB10	NP_001162804.1	Annexin	19..84	CDD:278615	39/64 (61%)
		Annexin	91..156	CDD:278615	25/64 (39%)
		Annexin	176..241	CDD:278615	27/64 (42%)
		Annexin	251..317	CDD:278615	36/65 (55%)
Anxa5	NP_033803.1	Annexin 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	13..84		41/70 (59%)
		Annexin	18..82	CDD:278615	39/63 (62%)
		Annexin 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	85..156		26/70 (37%)
		Annexin	89..154	CDD:278615	25/64 (39%)
		Annexin 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	168..240		29/71 (41%)
		Annexin	173..238	CDD:278615	27/64 (42%)
		Annexin 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	244..315		39/71 (55%)
		Annexin	248..313	CDD:278615	36/65 (55%)
		[IL]-x-C-x-x-[DE] motif. /evidence=ECO:0000250\|UniProtKB:P08758	312..318		2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0819
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3218
OMA	1	1.010	-	-		QHG54302
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000105
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10502
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X76
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.870