DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AnxB10 and Anxa4

DIOPT Version :9

Sequence 1:	NP_001162804.1	Gene:	AnxB10 / 33019	FlyBaseID:	FBgn0000084	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	NP_001318049.1	Gene:	Anxa4 / 11746	MGIID:	88030	Length:	319	Species:	Mus musculus

Alignment Length:	312	Identity:	145/312 - (46%)
Similarity:	207/312 - (66%)	Gaps:	2/312 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 TVKDAAPFDASQDAQVLRAAMKGFGTDEQEIIDVLVGRSNQQRQTIKAVYEAEFERDLVDDLKDE 72
            |||.|:.|:|::|||.||.||||.||||..||.:|..|:..|||.|::.|::...|||::|||.|
Mouse     7 TVKAASGFNATEDAQTLRKAMKGLGTDEDAIIGILAYRNTAQRQEIRSAYKSTIGRDLIEDLKSE 71

  Fly    73 LGGKFEDVIVGLMMPPVEYLCKQLHAAMAGIGTEEATLVEILCTKTNEEMAQIVAVYEERYQRPL 137
            |...||.||:|||.|.|.|..::|..||.|.||:|..|:|||.::|.||:.:|...|:::|.|.|
Mouse    72 LSSNFEQVILGLMTPTVLYDVQELRRAMKGAGTDEGCLIEILASRTPEEIRRINQTYQQQYGRSL 136

  Fly   138 AEQMCSETSGFFRRLLTLIVTGVRDGLDTPVDVGQAKEQAAQLYSAGEAKLGTDEEVFNRIMSHA 202
            .|.:||:||..|:|:|..:....||. ...:|....|:.|.:||.|||.:.||||..|..|:...
Mouse   137 EEDICSDTSFMFQRVLVSLSAAGRDE-GNYLDDALMKQDAQELYEAGEKRWGTDEVKFLSILCSR 200

  Fly   203 SFPQLRLVFEEYKVLSGQTIEQAIKHEMSDELHEAMMAIVECVQSPAAFFANRLYKAMNGAGTDD 267
            :...|..||:|||.:|.:.|||:||.|.|....:|::|||:|::|..::||.||||:|.|.||||
Mouse   201 NRNHLLHVFDEYKRISQKDIEQSIKSETSGSFEDALLAIVKCMRSKPSYFAERLYKSMKGLGTDD 265

  Fly   268 ATLIRIIVSRSEIDLETIKQEFERIYNRTLHSAVVDAETSGDYKRALTALLG 319
            .||||::|||:|||:..|:..|:|:|.::|:| .:..:|||||::.|..|.|
Mouse   266 NTLIRVMVSRAEIDMLDIRASFKRLYGKSLYS-FIKGDTSGDYRKVLLVLCG 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AnxB10	NP_001162804.1	Annexin	19..84	CDD:278615	34/64 (53%)
		Annexin	91..156	CDD:278615	28/64 (44%)
		Annexin	176..241	CDD:278615	27/64 (42%)
		Annexin	251..317	CDD:278615	34/65 (52%)
Anxa4	NP_001318049.1	Annexin 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	14..85		38/70 (54%)
		Annexin	19..83	CDD:395139	34/63 (54%)
		Annexin 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	86..157		30/70 (43%)
		Annexin	90..155	CDD:395139	28/64 (44%)
		Annexin 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	169..241		30/71 (42%)
		Annexin	173..239	CDD:395139	27/65 (42%)
		Annexin 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	245..316		36/71 (51%)
		Annexin	249..314	CDD:395139	34/65 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54302
OrthoDB	1	1.010	-	-		D500720at33208
OrthoFinder	1	1.000	-	-		FOG0000105
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10502
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X76
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.030