DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AnxB10 and Anxa11

DIOPT Version :9

Sequence 1:	NP_001162804.1	Gene:	AnxB10 / 33019	FlyBaseID:	FBgn0000084	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	NP_038497.2	Gene:	Anxa11 / 11744	MGIID:	108481	Length:	503	Species:	Mus musculus

Alignment Length:	312	Identity:	143/312 - (45%)
Similarity:	207/312 - (66%)	Gaps:	2/312 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 TVKDAAPFDASQDAQVLRAAMKGFGTDEQEIIDVLVGRSNQQRQTIKAVYEAEFERDLVDDLKDE 72
            |:..|:.||..:||:|||.||||||||||.|||.|..|||:|||.|...::..:.:||:.|||.|
Mouse   191 TITAASGFDPLRDAEVLRKAMKGFGTDEQAIIDCLGSRSNKQRQQILLSFKTAYGKDLIKDLKSE 255

  Fly    73 LGGKFEDVIVGLMMPPVEYLCKQLHAAMAGIGTEEATLVEILCTKTNEEMAQIVAVYEERYQRPL 137
            |.|.||..|:.||..||.:...::..|:.|.||:||.|:||..:::||.:.::...|:..:|:.|
Mouse   256 LSGNFEKTILALMKTPVLFDVYEIKEAIKGAGTDEACLIEIFASRSNEHIRELSRAYKTEFQKTL 320

  Fly   138 AEQMCSETSGFFRRLLTLIVTGVRDGLDTPVDVGQAKEQAAQLYSAGEAKLGTDEEVFNRIMSHA 202
            .|.:.|:|||.|:|||..:..|.||. .|.||:...:....:||:|||.:|||||..||.|:...
Mouse   321 EEAIRSDTSGHFQRLLISLSQGNRDE-STNVDMSLVQRDVQELYAAGENRLGTDESKFNAILCSR 384

  Fly   203 SFPQLRLVFEEYKVLSGQTIEQAIKHEMSDELHEAMMAIVECVQSPAAFFANRLYKAMNGAGTDD 267
            |...|..||.||:.::|:.||::|..|||.:|.:.|:|:|:|:::..||||.||.|||.||||.|
Mouse   385 SRAHLVAVFNEYQRMTGRDIEKSICREMSGDLEQGMLAVVKCLKNTPAFFAERLNKAMRGAGTKD 449

  Fly   268 ATLIRIIVSRSEIDLETIKQEFERIYNRTLHSAVVDAETSGDYKRALTALLG 319
            .|||||:|||||:||..|:.|::|:|.::|:..:. .:|||||::.|..:.|
Mouse   450 RTLIRIMVSRSELDLLDIRAEYKRMYGKSLYHDIT-GDTSGDYRKILLKICG 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AnxB10	NP_001162804.1	Annexin	19..84	CDD:278615	37/64 (58%)
		Annexin	91..156	CDD:278615	23/64 (36%)
		Annexin	176..241	CDD:278615	28/64 (44%)
		Annexin	251..317	CDD:278615	36/65 (55%)
Anxa11	NP_038497.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	80..172
		Cornifin	<120..185	CDD:280537
		Annexin 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	198..269		40/70 (57%)
		Annexin	202..267	CDD:365936	37/64 (58%)
		Annexin 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	270..341		25/70 (36%)
		Annexin	274..339	CDD:365936	23/64 (36%)
		Annexin 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	353..425		29/71 (41%)
		Annexin	357..423	CDD:365936	28/65 (43%)
		Annexin 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	429..500		37/71 (52%)
		Annexin	433..498	CDD:365936	36/65 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0819
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54302
OrthoDB	1	1.010	-	-		D500720at33208
OrthoFinder	1	1.000	-	-		FOG0000105
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X76
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.830