DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9581 and XPNPEP1

DIOPT Version :9

Sequence 1:	NP_608376.1	Gene:	CG9581 / 33017	FlyBaseID:	FBgn0031093	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_001311062.1	Gene:	XPNPEP1 / 7511	HGNCID:	12822	Length:	695	Species:	Homo sapiens

Alignment Length:	512	Identity:	116/512 - (22%)
Similarity:	194/512 - (37%)	Gaps:	162/512 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 VAQILRQQKGNLGQPTSVSHPHLIQPDELVPGVELTEIKERRSQLMQNIRAYARSFGGEFNGHS- 119
            :|::||          |..| |||...|.:.....|:..||..:.:..:       |.::.|.|
Human   175 MAKVLR----------SAGH-HLIPVKENLVDKIWTDRPERPCKPLLTL-------GLDYTGISW 221

  Fly   120 -SSCHMLVLGAASKKYM------SGKIPYVFR-QNSD-------FYYLTGCLEPDAVLLLTID-- 167
             .....|.|..|.:..|      ..:|.::|. :.||       |.|....||   .::|.||
Human   222 KDKVADLRLKMAERNVMWFVVTALDEIAWLFNLRGSDVEHNPVFFSYAIIGLE---TIMLFIDGD 283

  Fly   168 --EAQNVQSELFMRPKDPHAELWDGPRTGPELAVPLFGVTEAHP----LSQLEAVLAKRAGALKP 226
              :|.:|:..|.:                 :|.:......:.||    ||:|:|:.|.    |.|
Human   284 RIDAPSVKEHLLL-----------------DLGLEAEYRIQVHPYKSILSELKALCAD----LSP 327

  Fly   227 H--IWFDQKSTDLPSLAENMLRLSGNQQRPLLPAYTFLEAMRLLKSRDEMQLMRRT--------C 281
            .  :|...|::  .:::|.:.:    ..|..:| ||.:...:.:|:..|.:.|||.        |
Human   328 REKVWVSDKAS--YAVSETIPK----DHRCCMP-YTPICIAKAVKNSAESEGMRRAHIKDAVALC 385

  Fly   282 DIASRSFNEVMAET-RPGQSEHHLFAAID--YKCRMRNASY--LAYPPVVAAGKNATVIHYV--- 338
            ::    ||.:..|. :.|.:|   .:|.|  .:.|.:.|.:  |::|.:.:.|.|..:|||.
Human   386 EL----FNWLEKEVPKGGVTE---ISAADKAEEFRRQQADFVDLSFPTISSTGPNGAIIHYAPVP 443

  Fly   339 ANSQLLGQQDLVLMDAGCEYGGYTSDITRTWPASGVFTEPQRTLYDMLHQLQEEIIGNVMK---- 399
            ..::.|...::.|:|:|.:|...|:|:|||..    |..|  |.|      ::|....|:|
Human   444 ETNRTLSLDEVYLIDSGAQYKDGTTDVTRTMH----FGTP--TAY------EKECFTYVLKGHIA 496

  Fly   400 ---------PGGETLDQLFETTCYKLG-KYLQEIGLVGKSFSEYKELVSQGYRFCPHHVSHYLGM 454
                     ..|..||....:..:..| .||...|                     |.|..:|
Human   497 VSAAVFPTGTKGHLLDSFARSALWDSGLDYLHGTG---------------------HGVGSFL-- 538

  Fly   455 DVHDTP-----HVPRNTRIVPGMVFTVEPGIYIGQDCGDVPPEFRGIGIRIEDDLLI 506
            :||:.|     ....:..:..||:.|.|||.|          |....|||||:.:|:
Human   539 NVHEGPCGISYKTFSDEPLEAGMIVTDEPGYY----------EDGAFGIRIENVVLV 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9581	NP_608376.1	AMP_N	94..232	CDD:282980	34/163 (21%)
CG9581	NP_608376.1	Prolidase	274..517	CDD:238520	64/268 (24%)
XPNPEP1	NP_001311062.1	Creatinase_N	53..197	CDD:304957	9/32 (28%)
		Creatinase_N_2	207..369	CDD:292807	39/199 (20%)
		PepP	239..609	CDD:223085	97/430 (23%)
		APP	372..594	CDD:238518	64/266 (24%)
		Peptidase_M24_C	600..>627	CDD:292806
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0006
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810