DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9581 and CG6225

DIOPT Version :9

Sequence 1:	NP_608376.1	Gene:	CG9581 / 33017	FlyBaseID:	FBgn0031093	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_001097759.1	Gene:	CG6225 / 41559	FlyBaseID:	FBgn0038072	Length:	704	Species:	Drosophila melanogaster

Alignment Length:	476	Identity:	95/476 - (19%)
Similarity:	168/476 - (35%)	Gaps:	143/476 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 ERRSQLMQN--IRAYARSFGGEF-----------NGHSSSCHMLVLGAASKKYM----SGKIPY- 141
            :.|.::.:|  |:.:.:.|.||.           ..|.....|:|.......|:    ...|||
  Fly   198 DERPEMPKNQVIKVHEKHFAGESWQDKVKELRRRLAHLGCDAMVVTSLTEIAYLLNIRGTDIPYT 262

  Fly   142 -------VFRQNSDFYYL--------------TGCLEPDAVLLLTIDEAQNVQSELFMRPKDPHA 185
                   |..::..|:|:              |.|...|.|   .|.|...:.|::     ..:|
  Fly   263 PVIKSYAVISRDDIFFYVDHSKISLGIDLHLRTDCFNEDCV---KIKEYNQIWSDI-----RTYA 319

  Fly   186 ELWDGPRTGPELAVPLFGVTEAHPLSQLEAVLAKRAGALKPHIWFDQKSTDLPSLAENMLRLSGN 250
            ::|      ..:.||...|.:   |...||:.....|  |..:|
  Fly   320 QIW------KRVLVPAPCVQD---LGASEAIYTSMPG--KIVVW--------------------- 352

  Fly   251 QQRPLLPAYTFLEAMRLLKSRDEMQLMRRT--------CDIASRSFNEVMAETRPGQSEHHLFAA 307
            :..|::       .||..|:.||...|||.        |:..|..  |....|.....|...:..
  Fly   353 EISPII-------FMRAQKNSDEQAGMRRAHIRDGAAICEAMSNM--ETRFHTEQWTEEKIKYEV 408

  Fly   308 IDYKCRMRNASYLAYPPVVAAGKNATVIHYVANSQL---LGQQDLVLMDAGCEYGGYTSDITRTW 369
            ..::...::|..|:...|||.|:::.:.:|::::..   :..|.|:::::|.:|...|:|::||:
  Fly   409 ELWRLSQKHAKGLSLRTVVAYGEHSALPYYISSNVTNIEVSDQSLLVIESGGQYLEGTTDVSRTF 473

  Fly   370 PASGVFTEP--------QRTLYDMLHQLQEEIIGNVMKPGGETLDQLFETTCYK-LGKYLQEIGL 425
                :|.||        ...|..:||..|.:...: :||  ..:|.|..:..:| :..:.|..|.
  Fly   474 ----IFGEPTHEMKKAYTNVLAGILHLAQLKFPSD-LKP--SEVDALVRSMVWKDMTDFPQATGH 531

  Fly   426 VGKSFSEYKELVSQGYRFCPHHVSHYLGMDVHDTPHVPRNTRIVPGMVFTVEPGIYIGQDCGDVP 490
            ...||...:|        .|..||:......|          ...|..|:.|.|.|...|
  Fly   532 GIGSFGSVEE--------PPISVSYGKNSSFH----------FKQGYFFSSESGYYKRDD----- 573

  Fly   491 PEFRGIGIRIEDDLLINENGH 511
                 .|:|:::.|.:.:.||
  Fly   574 -----FGVRLKNVLEVVDTGH 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9581	NP_608376.1	AMP_N	94..232	CDD:282980	34/175 (19%)
CG9581	NP_608376.1	Prolidase	274..517	CDD:238520	55/258 (21%)
CG6225	NP_001097759.1	Creatinase_N	92..195	CDD:304957
		Creatinase_N_2	209..368	CDD:292807	36/205 (18%)
		PepP	213..589	CDD:223085	90/459 (20%)
		APP	371..594	CDD:238518	55/256 (21%)
		Peptidase_M24_C	597..660	CDD:292806
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0006
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810