DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9581 and CG32454

DIOPT Version :9

Sequence 1:	NP_608376.1	Gene:	CG9581 / 33017	FlyBaseID:	FBgn0031093	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_730740.1	Gene:	CG32454 / 318037	FlyBaseID:	FBgn0260481	Length:	534	Species:	Drosophila melanogaster

Alignment Length:	569	Identity:	155/569 - (27%)
Similarity:	247/569 - (43%)	Gaps:	96/569 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LRRLDRLIAPTVRRSA-AISTSLWPHRWMSQSTTISPGSPSSKSTVNA--AEVRGVAQILRQQKG 65
            :||...::||..|... .:..::||.....:...:|......|.:.:|  .:...:::.||
  Fly    16 VRRGCSVVAPPDRSDVLLVLPTVWPSELTKRIRPLSVPDLIEKFSCDAPGGQFATMSEYLR---- 76

  Fly    66 NLGQPTSVSHPHLIQPDELVPGVEL-TEIKERRSQLMQNIRAYARSFGGEFNGHSSS---CHMLV 126
                    |.|   :||    ||.| .||...|...:.::.:|..:.......|..:   .|:||
  Fly    77 --------SDP---RPD----GVLLPDEIDLHRKMSLDDLNSYMHAKDAFKEPHRKNRIFSHVLV 126

  Fly   127 L-GAASKKYMSGKIPYVFRQNSDFYYLTGCLEPDAVLLLTIDEAQNVQSELFMRPKDPHAELWDG 190
            : ||.|.:      .|.|||..||.||..||.|.|.|:||....:|..:.||: .:|..::|
  Fly   127 VAGADSAR------SYPFRQRPDFLYLCDCLRPGAALVLTRSRKRNTGALLFL-SQDVDSQL--- 181

  Fly   191 PRTGPELAVPLFGVTEAHPLSQLEAVLAKRAGALKPHIW-FDQKSTDLPSLAENMLRLS----GN 250
                ..:...:..|.:..||:.|:..|........|.:| |...|:.:..:.:.:...:    ||
  Fly   182 ----STIFSHMHYVDDVLPLAMLKKSLLWLLRDHSPELWHFYDPSSPVSCIVQEVANEAKIPMGN 242

  Fly   251 QQRPLLPAYTFLEAMRLLKSRDEMQLMRRTCDIASRSFNEVMAETRPGQSEHH-----LFAAIDY 310
                  |.| .|:..|.:|:..|::.:||....|:.|..||:|       :||     |.|:.||
  Fly   243 ------PRY-ILQYTRTVKTSRELRALRRANATAADSMAEVIA-------QHHQIPQELAASFDY 293

  Fly   311 KCRMRNASYLAYPPVVAAGKNATVIHYVANSQLLGQQDLVLMDAGCEYGGYTSDITRTWPASGVF 375
            |||:|:|.    |.|            ...|..|....|..|||||:||||...:.|.||:||.|
  Fly   294 KCRLRHAR----PDV------------TKTSCGLDGNGLWQMDAGCQYGGYEGGLARCWPSSGRF 342

  Fly   376 TEPQRTLYDMLHQLQEEIIGNVMKPGGE----TLDQLFETTCYKLGKYLQEIGLVGKSFSEYKEL 436
            |.||:.:|..|..::.::...:...|.|    |..:|.......|.::|:|:.::.|..|...|.
  Fly   343 TPPQKMIYGALLDMRRDLCSLIQYAGCEGAVRTPLELHAAYLILLARHLRELRVLPKGVSSAAET 407

  Fly   437 V--SQGYRFCPHHVSHYLGMDVHDTPHVPRNTRIVPGMVFTVEPGIYIGQDCGDVPPEFRGIGIR 499
            |  ::.|...|..||| :|:...||.....:....||.|.::...|.|..||....||||||..:
  Fly   408 VELARKYNCSPVVVSH-VGLGKRDTSRRLLDYPFAPGNVMSLRLSISIPDDCCQAYPEFRGILCQ 471

  Fly   500 IEDDLLINENGHVEVLTEACVKDPRALQELC-------KQQQKNPGASS 541
            :.|.|.:.::..|::||.||..:|:.: |:|       ..:.:|.|..|
  Fly   472 LGDTLHVRDDYSVDLLTAACPSEPQDI-EVCLPASRTRSHRLRNDGDQS 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9581	NP_608376.1	AMP_N	94..232	CDD:282980	37/142 (26%)
CG9581	NP_608376.1	Prolidase	274..517	CDD:238520	79/253 (31%)
CG32454	NP_730740.1	Creatinase_N	106..223	CDD:304957	35/130 (27%)
CG32454	NP_730740.1	APP_MetAP	259..468	CDD:294199	73/232 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0006
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D200485at33208
OrthoFinder	1	1.000	-	-		FOG0003565
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.820