DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9581 and icp55

DIOPT Version :9

Sequence 1:	NP_608376.1	Gene:	CG9581 / 33017	FlyBaseID:	FBgn0031093	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_594637.1	Gene:	icp55 / 2542952	PomBaseID:	SPAC12B10.05	Length:	486	Species:	Schizosaccharomyces pombe

Alignment Length:	499	Identity:	146/499 - (29%)
Similarity:	253/499 - (50%)	Gaps:	57/499 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 AQILRQQKGNL----------GQPTSVSHPHLIQPDELVPGVELTEIKERRSQLMQNIRAYARSF 111
            :||::.:..|:          ||.|..:|||::||.||.|.:...|.|.||.::...:
pombe    21 SQIIKYKYSNVSYLNKSALRCGQATDSTHPHILQPGELTPRISAQEYKTRRDRVASLL------- 78

  Fly   112 GGEFNGHSSSCHMLVLGAASKKYMSGKIPYVFRQNSDFYYLTGCLEPDAVLLLTIDEAQ-NVQSE 175
              |.|      ..:::.:|..::|.|...|.:.|:.:||||||||||:||||:..:.|. :....
pombe    79 --EDN------DFMIVTSAPVRHMCGAAFYEYHQDPNFYYLTGCLEPNAVLLMFKNGASGSYDCS 135

  Fly   176 LFMRPKDPHAELWDGPRTGPELAVPLFGVTEAHPLSQLEAVLAKRAGALKPHIWFDQKS---TDL 237
            |::..|:|:.|.|:|.|||..|...||.:...:. |.|.:.:....|.....|:::.::   :.:
pombe   136 LYLPSKNPYIEKWEGLRTGSTLGKKLFQIENVYD-SSLASSVINALGKKSNRIFYNYQTGYLSKM 199

  Fly   238 PS------LAENMLRL-SGNQQRPLLPAYTFLEAMRLLKSRDEMQLMRRTCDIASRSFNEVMAET 295
            |:      :.:.:.:| ..:.||.:   ...|..:|.:||..|::.|:...:|:|..:.|:|  .
pombe   200 PAASAPEFIQDTLTKLFRTSTQRSV---DELLHPLRSIKSTAELECMKEAANISSNVYREIM--R 259

  Fly   296 RPGQSEHHLFAAIDYKCRMRNASYLAYPPVVAAGKNATVIHYVANSQLLGQQDLVLMDAGCEYGG 360
            :..:.|..:.|..:|:..:......||.||||.|||...|||..|:.:....::||:|||.|:||
pombe   260 KRFEKEAEMSAEFNYRFCIGGCDRSAYVPVVAGGKNGLTIHYTINNDIFRPDEMVLVDAGGEFGG 324

  Fly   361 YTSDITRTWPASGVFTEPQRTLYDMLHQLQEEIIGNVMKPGGETLDQLFETTCYKLGKYLQEIGL 425
            |.:||:||||.:|.|:..||.||..:..:|::.|.......|.:|..:...:...:.:.|:::|:
pombe   325 YVTDISRTWPINGKFSTVQRDLYQAVLNVQKKCIKYCCTSNGWSLADIHFESVKLMHEELKQVGI 389

  Fly   426 VGKSFSEYKELVSQGYRFCPHHVSHYLGMDVHDTPHVPRNTRIVP---GMVFTVEPGIYIGQDCG 487
            .|..    :|:....|   ||.:.|.:|:::||   ...|....|   ..|.|:|||:|:.::.|
pombe   390 HGTK----REITDILY---PHSIGHEIGLEIHD---CSTNNGYQPLRKNQVITIEPGLYVPEEDG 444

  Fly   488 DVPPEFRGIGIRIEDDLLINENGHVEVLTEACVKDPRALQELCK 531
             .|...:||.|||||.:::.::... |||.|..|:...::.|.|
pombe   445 -WPQWAQGIAIRIEDSVIVGDDKPF-VLTSAAPKEIEEIEALKK 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9581	NP_608376.1	AMP_N	94..232	CDD:282980	41/138 (30%)
CG9581	NP_608376.1	Prolidase	274..517	CDD:238520	76/245 (31%)
icp55	NP_594637.1	PepP	58..482	CDD:223085	132/456 (29%)
		AMP_N	62..191	CDD:198079	42/144 (29%)
		Prolidase	240..472	CDD:238520	76/245 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	127	1.000	Domainoid score	I1373
eggNOG	1	0.900	-	-		E1_COG0006
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5827
Inparanoid	1	1.050	212	1.000	Inparanoid score	I947
OMA	1	1.010	-	-		QHG55416
OrthoFinder	1	1.000	-	-		FOG0003565
OrthoInspector	1	1.000	-	-		oto100638
orthoMCL	1	0.900	-	-		OOG6_100598
Panther	1	1.100	-	-	LDO	PTHR43226
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R584
SonicParanoid	1	1.000	-	-		X2916
TreeFam	1	0.960	-	-
	14	13.860