DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9581 and R119.2

DIOPT Version :9

Sequence 1:	NP_608376.1	Gene:	CG9581 / 33017	FlyBaseID:	FBgn0031093	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_490725.3	Gene:	R119.2 / 187899	WormBaseID:	WBGene00020088	Length:	444	Species:	Caenorhabditis elegans

Alignment Length:	452	Identity:	152/452 - (33%)
Similarity:	236/452 - (52%)	Gaps:	45/452 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 EIKERRSQLMQNIRAYARSFGGEFNGHSSSCHMLVLGAASKKYMSGKIPYVFRQNSDFYYLTGCL 156
            |...||:.||..::...::  ||      ...::|:..|.|.|::..:|:.|||.|.|.||.|..
Worm    19 EYAMRRTNLMNLLKKEVKT--GE------KQVVVVMKGARKSYIAPDVPHAFRQKSHFRYLNGIT 75

  Fly   157 EPDAVLLLT--IDEAQNVQSELFMRPKDPHAELWDGPRTGPELAVPLFG-------VTEAHPLSQ 212
            .||...::.  |.|:....:.||...:..:.|||:|       |:|...       .||..|.|:
Worm    76 TPDCYYIMQSGISESSKETNILFADRRSAYDELWEG-------ALPTESEWEKTAKFTECVPTSR 133

  Fly   213 ----LEAVLAKRAGALKPHIWFDQKSTDLPSLAENMLRLSGNQQRPLLPAYTFLEAMRLLKSRDE 273
                ||.|..|...     ::||..|.|   |....::...|..|.:   ..|:|..|::||..|
Worm   134 ILQTLEKVCDKGTA-----VFFDSTSDD---LLYKFVQAKANSVREI---NHFIERRRVIKSPSE 187

  Fly   274 MQLMRRTCDIASRSFNEVMAETRPGQSEHHLFAAIDYKCRMRNASYLAYPPVVAAGKNATVIHYV 338
            |..||..|::.:::.:.:::.:|...:|:.:...::::.|.|.:...|||||:|.|..|..|||:
Worm   188 MSSMRDVCNVGAQTMSSMISGSRDLHNENAICGLLEFEGRRRGSEMQAYPPVIAGGVRANTIHYL 252

  Fly   339 ANSQLLGQQDLVLMDAGCEYGGYTSDITRTWPASGVFTEPQRTLYDMLHQLQEEIIGNVMKPGGE 403
            ..:..|..::.||:||||:..||.||:||.:|.||.:::.|.:||:.|..:.||::.........
Worm   253 DANNDLNPRECVLVDAGCDLNGYVSDVTRCFPISGFWSDAQLSLYEALLYVHEELLTYAHSMEKV 317

  Fly   404 TLDQLFETTCYKLGKYLQEIGLVGKSFSEYKELVSQGYRFCPHHVSHYLGMDVHDTPHVPRNTRI 468
            .|..||......|.....|:||:..  :::||::.|..:.|||||||||||||||.|.|.|:..:
Worm   318 RLSALFRRMNELLAASFTELGLIRS--TDHKEMIHQAEKLCPHHVSHYLGMDVHDCPTVSRDIDL 380

  Fly   469 VPGMVFTVEPGIYIGQDCGDVP-PEFRGIGIRIEDDLLINENGHVEVLTEACVKDPRALQEL 529
            .|.:.||:|||:|:..|.   | .||||||.|||||:..:|.|.:|:||.|..:||..:|.|
Worm   381 PPNVPFTIEPGVYVPMDW---PVKEFRGIGYRIEDDVATSEAGGIELLTAAVPRDPIEIQRL 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9581	NP_608376.1	AMP_N	94..232	CDD:282980	40/150 (27%)
CG9581	NP_608376.1	Prolidase	274..517	CDD:238520	93/243 (38%)
R119.2	NP_490725.3	AMP_N	20..149	CDD:377484	39/148 (26%)
R119.2	NP_490725.3	APP_MetAP	188..427	CDD:381919	93/243 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	174	1.000	Domainoid score	I2204
eggNOG	1	0.900	-	-		E1_COG0006
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	241	1.000	Inparanoid score	I2100
Isobase	1	0.950	-	0	Normalized mean entropy	S2853
OMA	1	1.010	-	-		QHG55416
OrthoDB	1	1.010	-	-		D200485at33208
OrthoFinder	1	1.000	-	-		FOG0003565
OrthoInspector	1	1.000	-	-		oto19614
orthoMCL	1	0.900	-	-		OOG6_100598
Panther	1	1.100	-	-	LDO	PTHR43226
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R584
SonicParanoid	1	1.000	-	-		X2916
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.820