DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9577 and ECH1

DIOPT Version :9

Sequence 1:	NP_608375.1	Gene:	CG9577 / 33016	FlyBaseID:	FBgn0031092	Length:	312	Species:	Drosophila melanogaster
Sequence 2:	XP_024307176.1	Gene:	ECH1 / 1891	HGNCID:	3149	Length:	390	Species:	Homo sapiens

Alignment Length:	350	Identity:	149/350 - (42%)
Similarity:	205/350 - (58%)	Gaps:	72/350 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 ALPESGPTGSFKTLAVSSPKPFVFHVELHRPSKFNAISKQMWLEIKECFDGLATNPDCRAIVLSA 94
            ||.|: |..|:::|.|:|.:..|.||:|:||:|.||::|..|.|:.|||:.::.:.||||:|:|.
Human    46 ALGEA-PDHSYESLRVTSAQKHVLHVQLNRPNKRNAMNKVFWREMVECFNKISRDADCRAVVISG 109

  Fly    95 SGKHFTAGIDLNDMI-NVGQTLAETDDYARKGVSMERMIKVYQDSISSLEHCPKPVITAVHKACI 158
            :||.|||||||.||. ::.|  .:.||.||....:..:|..||::.:.:|.||||||.|||..||
Human   110 AGKMFTAGIDLMDMASDILQ--PKGDDVARISWYLRDIITRYQETFNVIERCPKPVIAAVHGGCI 172

  Fly   159 GA--------------------------------------------------------------G 161
            |.                                                              |
Human   173 GGGESAAILLLGCSPGGAAAPMPRPLASSLSSVMGQTVSQEAAPPPGSQGWFWWSFSIPGLYLLG 237

  Fly   162 VDLITAADIRYCTEDAFFQVKEVDIGMAADVGTLQRLPKAVGSQSLARELCFTGRKFEAAEAHSS 226
            |||:||.|||||.:||||||||||:|:||||||||||||.:|:|||..||.||.||..|.||..|
Human   238 VDLVTACDIRYCAQDAFFQVKEVDVGLAADVGTLQRLPKVIGNQSLVNELAFTARKMMADEALGS 302

  Fly   227 GLVSRLFPDKDSLLTGALAVAELIASKSPVAVKTTKESLVYSLEHTNQEGLDHILLLNKLNLLSE 291
            |||||:||||:.:|..|||:|..|:|||||||::||.:|:||.:|:..|.|:::...|...|.::
Human   303 GLVSRVFPDKEVMLDAALALAAEISSKSPVAVQSTKVNLLYSRDHSVAESLNYVASWNMSMLQTQ 367

  Fly   292 DFAQAVAAQLTKDDKPV----FAKL 312
            |..::|  |.|.::|.:    |:||
Human   368 DLVKSV--QATTENKELKTVTFSKL 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9577	NP_608375.1	crotonase-like	52..310	CDD:304874	138/324 (43%)
CG9577	NP_608375.1	PRK05617	54..309	CDD:235533	137/321 (43%)
ECH1	XP_024307176.1	crotonase-like	54..378	CDD:329030	141/327 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	257	1.000	Domainoid score	I2031
eggNOG	1	0.900	-	-		E1_KOG1681
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1069
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2991
Isobase	1	0.950	-	0.815465	Normalized mean entropy	S2322
OMA	1	1.010	-	-		QHG55028
OrthoDB	1	1.010	-	-		D1094098at2759
OrthoFinder	1	1.000	-	-		FOG0005814
OrthoInspector	1	1.000	-	-		oto89751
orthoMCL	1	0.900	-	-		OOG6_102762
Panther	1	1.100	-	-	LDO	PTHR43149
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3831
SonicParanoid	1	1.000	-	-		X4206
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820