DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phf7 and KMT2B

DIOPT Version :9

Sequence 1:	NP_001259740.1	Gene:	Phf7 / 33015	FlyBaseID:	FBgn0031091	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_055542.1	Gene:	KMT2B / 9757	HGNCID:	15840	Length:	2715	Species:	Homo sapiens

Alignment Length:	525	Identity:	108/525 - (20%)
Similarity:	164/525 - (31%)	Gaps:	178/525 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 CVLCLS-GERDELIFG-TVHVEGNMMVHRNCLYLSSNLIQRGEKKLSIMNFLKEDIEAEVNRCRL 67
            |.|||. |:.|....| .:::..|...|.||...|:.:.:..:..|       :::.|.|.|.|.
Human  1581 CALCLKYGDADSKEAGRLLYIGQNEWTHVNCAIWSAEVFEENDGSL-------KNVHAAVARGRQ 1638

  Fly    68 LKCCYCRRLGANIWCCKSGCRRTFHTKCGVDNLAQNQFC---DTYNSFCHQHVLVPRNRPVFKND 129
            ::|..|.:.||.:.||.|.|...||..|     |:..:|   |....||.:|.
Human  1639 MRCELCLKPGATVGCCLSSCLSNFHFMC-----ARASYCIFQDDKKVFCQKHT------------ 1686

  Fly   130 EECLLCAEDVVAKGERFSVVTCLYAPCCRNGWFHRRCLQRYANSSGYFFKCPLCNNTDVFRRVAY 194
              .||..:::|                               |..|:          ||.||| |
Human  1687 --DLLDGKEIV-------------------------------NPDGF----------DVLRRV-Y 1707

  Fly   195 MGIAVLDQDASWET--EPDAFAGQYRRDVNCTAALCVAVSGRADTSAMLLYCTSCGAN--PSHYL 255
            :....::....:.|  ||||        :|....     |.|.|:...|...:.|...  |..|.
Human  1708 VDFEGINFKRKFLTGLEPDA--------INVLIG-----SIRIDSLGTLSDLSDCEGRLFPIGYQ 1759

  Fly   256 C------TLKTLQN--YVCKVCS------AVSPEAVPVAESDSDDAGSMDDSAEAPR-------- 298
            |      |:...:.  |.|::..      ...|..:..||.:.....|...|:|.|.
Human  1760 CSRLYWSTVDARRRCWYRCRILEYRPWGPREEPAHLEAAEENQTIVHSPAPSSEPPGGEDPPLDT 1824

  Fly   299 ----PGHLNGDQIQEKLSPSHWDDFGSSDDDAVFQRAFDTKVQSRVVTLSDDQPSTSAGARALAD 359
                ||........:.|.|....|.||:...|  .|:|.   .:|:..     |:.|...|.|..
Human  1825 DVLVPGAPERHSPIQNLDPPLRPDSGSAPPPA--PRSFS---GARIKV-----PNYSPSRRPLGG 1879

  Fly   360 RGTRTFESQGTQTTFLSSVVTSFRSATATATSSTSTSTSTSASTLDNQENTEPSTSNGR------ 418
            .......|.|:.::....:                       .|:.:.:...|...:.|
Human  1880 VSFGPLPSPGSPSSLTHHI-----------------------PTVGDPDFPAPPRRSRRPSPLAP 1921

  Fly   419 RPWRPRYVSPPRHVSDSDDDSDEYDSDEYESKRRQLTP-----TAAAPSNGRRLLGSISPEPSTP 478
            ||...|:.|||...                |.:.::.|     ||..|::|.  |....|.||.|
Human  1922 RPPPSRWASPPLKT----------------SPQLRVPPPTSVVTALTPTSGE--LAPPGPAPSPP 1968

  Fly   479 APRVL 483
            .|..|
Human  1969 PPEDL 1973

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phf7	NP_001259740.1	ePHD_PHF7_G2E3_like	5..116	CDD:277139	33/115 (29%)
KMT2B	NP_055542.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..65
		Menin-binding motif (MBM). /evidence=ECO:0000269\|PubMed:22327296	17..36
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..302
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	320..518
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..771
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..868
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	894..959
		zf-CXXC	958..1005	CDD:251032
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1027..1132
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1146..1166
		PHD1_KMT2B	1203..1249	CDD:277064
		PHD2_KMT2B	1251..1300	CDD:277066
		PHD3_KMT2B	1337..1393	CDD:277068
		Bromo_ALL-1	1374..1516	CDD:99925
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1545..1567
		ePHD_KMT2B	1581..1685	CDD:277164	33/115 (29%)
		FYRN	1734..1780	CDD:283589	11/45 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1806..1978		43/219 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2008..2093
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2118..2162
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2280..2412
		FYRC	2413..2497	CDD:197781
		WDR5 interaction motif (WIN). /evidence=ECO:0000269\|PubMed:22266653, ECO:0000269\|PubMed:22665483	2508..2513
		SET	<2559..2715	CDD:225491
		SET	2577..2697	CDD:214614
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250\|UniProtKB:Q03164	2652..2653
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810