Protein Alignment Phf7 and KMT2B

DIOPT Version :10

• Sequence 1: NP_608374.1
• Gene: Phf7 / 33015
• FlyBaseID: FBgn0031091
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_055542.1
• Gene: KMT2B / 9757
• HGNCID: 15840
• Length: 2715
• Species: Homo sapiens
• Alignment Length: 525
• Identity: 108/525 - (20%)
• Similarity: 164/525 - (31%)
• Gaps: 178/525 - (33%)

  Fly     5 CVLCLS-GERDELIFG-TVHVEGNMMVHRNCLYLSSNLIQRGEKKLSIMNFLKEDIEAEVNRCRL 67
            |.|||. |:.|....| .:::..|...|.||...|:.:.:..:..|       :::.|.|.|.|.
Human  1581 CALCLKYGDADSKEAGRLLYIGQNEWTHVNCAIWSAEVFEENDGSL-------KNVHAAVARGRQ 1638

  Fly    68 LKCCYCRRLGANIWCCKSGCRRTFHTKCGVDNLAQNQFC---DTYNSFCHQHVLVPRNRPVFKND 129
            ::|..|.:.||.:.||.|.|...||..|     |:..:|   |....||.:|.
Human  1639 MRCELCLKPGATVGCCLSSCLSNFHFMC-----ARASYCIFQDDKKVFCQKHT------------ 1686

  Fly   130 EECLLCAEDVVAKGERFSVVTCLYAPCCRNGWFHRRCLQRYANSSGYFFKCPLCNNTDVFRRVAY 194
              .||..:::|                               |..|:          ||.||| |
Human  1687 --DLLDGKEIV-------------------------------NPDGF----------DVLRRV-Y 1707

  Fly   195 MGIAVLDQDASWET--EPDAFAGQYRRDVNCTAALCVAVSGRADTSAMLLYCTSCGAN--PSHYL 255
            :....::....:.|  ||||        :|....     |.|.|:...|...:.|...  |..|.
Human  1708 VDFEGINFKRKFLTGLEPDA--------INVLIG-----SIRIDSLGTLSDLSDCEGRLFPIGYQ 1759

  Fly   256 C------TLKTLQN--YVCKVCS------AVSPEAVPVAESDSDDAGSMDDSAEAPR-------- 298
            |      |:...:.  |.|::..      ...|..:..||.:.....|...|:|.|.
Human  1760 CSRLYWSTVDARRRCWYRCRILEYRPWGPREEPAHLEAAEENQTIVHSPAPSSEPPGGEDPPLDT 1824

  Fly   299 ----PGHLNGDQIQEKLSPSHWDDFGSSDDDAVFQRAFDTKVQSRVVTLSDDQPSTSAGARALAD 359
                ||........:.|.|....|.||:...|  .|:|.   .:|:..     |:.|...|.|..
Human  1825 DVLVPGAPERHSPIQNLDPPLRPDSGSAPPPA--PRSFS---GARIKV-----PNYSPSRRPLGG 1879

  Fly   360 RGTRTFESQGTQTTFLSSVVTSFRSATATATSSTSTSTSTSASTLDNQENTEPSTSNGR------ 418
            .......|.|:.::....:                       .|:.:.:...|...:.|
Human  1880 VSFGPLPSPGSPSSLTHHI-----------------------PTVGDPDFPAPPRRSRRPSPLAP 1921

  Fly   419 RPWRPRYVSPPRHVSDSDDDSDEYDSDEYESKRRQLTP-----TAAAPSNGRRLLGSISPEPSTP 478
            ||...|:.|||...                |.:.::.|     ||..|::|.  |....|.||.|
Human  1922 RPPPSRWASPPLKT----------------SPQLRVPPPTSVVTALTPTSGE--LAPPGPAPSPP 1968

  Fly   479 APRVL 483
            .|..|
Human  1969 PPEDL 1973

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Phf7	NP_608374.1	ePHD_PHF7_G2E3_like	5..116	CDD:277139	33/115 (29%)
		RING_Ubox	129..183	CDD:473075	5/53 (9%)
KMT2B	NP_055542.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..65
		Menin-binding motif (MBM). /evidence=ECO:0000269|PubMed:22327296	17..36
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	81..302
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	320..518
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	532..771
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	819..868
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	894..959
		zf-CXXC	958..1005	CDD:366873
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1027..1132
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1146..1166
		PHD1_KMT2B	1203..1249	CDD:277064
		PHD2_KMT2B	1251..1300	CDD:277066
		PHD3_KMT2B	1337..1393	CDD:277068
		Bromo_ALL-1	1374..1516	CDD:99925
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1545..1567
		ePHD_KMT2B	1581..1685	CDD:277164	33/115 (29%)
		FYRN	1733..1780	CDD:461787	11/51 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1806..1978		43/219 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2008..2093
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2118..2162
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2280..2412
		FYRC	2413..2497	CDD:197781
		WDR5 interaction motif (WIN). /evidence=ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:22665483	2508..2513
		SET_KMT2A_2B	2562..2715	CDD:380947