DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phf7 and PHF6

DIOPT Version :9

Sequence 1:	NP_001259740.1	Gene:	Phf7 / 33015	FlyBaseID:	FBgn0031091	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001015877.1	Gene:	PHF6 / 84295	HGNCID:	18145	Length:	365	Species:	Homo sapiens

Alignment Length:	413	Identity:	79/413 - (19%)
Similarity:	111/413 - (26%)	Gaps:	182/413 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 CVLCLSGERDELIFGTVHVEGNMMV--HRNCLYLSSNLIQRGEKKLSIMNFLKEDIEAEVNRCRL 67
            |..|.|....|.  |.:.:..|..|  |..|:..||.|:.......|:..|..||::.|:.|...
Human    17 CGFCKSNRDKEC--GQLLISENQKVAAHHKCMLFSSALVSSHSDNESLGGFSIEDVQKEIKRGTK 79

  Fly    68 LKCCYCRRLGANIWCCKSGCRRTFHTKCGVDNLAQ----------------------NQFCDTYN 110
            |.|..|...||.|.|....|.||:|..|.:.:.||                      |...|...
Human    80 LMCSLCHCPGATIGCDVKTCHRTYHYHCALHDKAQIREKPSQGIYMVYCRKHKKTAHNSEADLEE 144

  Fly   111 SFCHQHVLVP----------RNRPVFKN----------------DE------------------- 130
            || ::|.|.|          :.||...|                ||
Human   145 SF-NEHELEPSSPKSKKKSRKGRPRKTNFKGLSEDTRSTSSHGTDEMESSSYRDRSPHRSSPSDT 208

  Fly   131 --ECLLC---AEDVVAKGERFSVVTCLYAPCCRNGWFHRRCL-------QRYANSSGYF------ 177
              :|..|   .|:..|:|:       |:....:....|.:|:       |....|...|
Human   209 RPKCGFCHVGEEENEARGK-------LHIFNAKKAAAHYKCMLFSSGTVQLTTTSRAEFGDFDIK 266

  Fly   178 -----------FKCPLCNNTDVFRRVAYMGIAVLDQDASWETEPDAFAGQYRRDVNCTAALCVAV 231
                       .||.||                        ::|.|..|       |....||
Human   267 TVLQEIKRGKRMKCTLC------------------------SQPGATIG-------CEIKACV-- 298

  Fly   232 SGRADTSAMLLYCTSCGANPSHYLCTLKTLQNYV-----------CKVCSAVSPEAVPVAESDSD 285
                              ...||.|.::....|:           ||            ..|.:|
Human   299 ------------------KTYHYHCGVQDKAKYIENMSRGIYKLYCK------------NHSGND 333

  Fly   286 DAGSMDDSAEAPRPGHLNGDQIQ 308
            :....|:..|:...|.:..||.|
Human   334 ERDEEDEERESKSRGKVEIDQQQ 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phf7	NP_001259740.1	ePHD_PHF7_G2E3_like	5..116	CDD:277139	36/134 (27%)
PHF6	NP_001015877.1	Nuclear localization signal. /evidence=ECO:0000255	13..16
		Extended PHD1 domain (ePHD1). /evidence=ECO:0000255\|PROSITE-ProRule:PRU01146	14..132		32/116 (28%)
		ePHD1_PHF6	17..131	CDD:277180	32/115 (28%)
		Nuclear localization signal. /evidence=ECO:0000255	129..133		0/3 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..211		11/72 (15%)
		Nucleolar localization signal. /evidence=ECO:0000255	157..169		2/11 (18%)
		Extended PHD2 domain (ePHD2). /evidence=ECO:0000255\|PROSITE-ProRule:PRU01146	209..330		27/190 (14%)
		ePHD2_PHF6	212..329	CDD:277181	27/186 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	330..365		8/27 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141431
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12420
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.800