Protein Alignment Phf7 and Kmt2b

DIOPT Version :10

• Sequence 1: NP_608374.1
• Gene: Phf7 / 33015
• FlyBaseID: FBgn0031091
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_001277502.1
• Gene: Kmt2b / 75410
• MGIID: 109565
• Length: 2722
• Species: Mus musculus
• Alignment Length: 608
• Identity: 124/608 - (20%)
• Similarity: 184/608 - (30%)
• Gaps: 217/608 - (35%)

  Fly     5 CVLCLS-GERDELIFG-TVHVEGNMMVHRNCLYLSSNLIQRGEKKLSIMNFLKEDIEAEVNRCRL 67
            |.|||. |:.|....| .:::..|...|.||...|:.:.:..:..|       :::.|.|.|.|.
Mouse  1587 CALCLKYGDADSKEAGRLLYIGQNEWTHVNCAIWSAEVFEENDGSL-------KNVHAAVARGRQ 1644

  Fly    68 LKCCYCRRLGANIWCCKSGCRRTFHTKCGVDNLAQNQFC---DTYNSFCHQHVLVPRNRPVFKND 129
            ::|..|.:.||.:.||.|.|...||..|     |:..:|   |....||.:|.
Mouse  1645 MRCELCLKPGATVGCCLSSCLSNFHFMC-----ARASYCIFQDDKKVFCQKHT------------ 1692

  Fly   130 EECLLCAEDVVAKGERFSVVTCLYAPCCRNGWFHRRCLQRYANSSGYFFKCPLCNNTDVFRRVAY 194
              .||..:::|.. :.|.|:              ||.   |.:..|..||           |...
Mouse  1693 --DLLDGKEIVTP-DGFDVL--------------RRV---YVDFEGINFK-----------RKFL 1726

  Fly   195 MGIAVLDQDASWETEPD---AFAGQYRRDVNCTAALCVAVSGRADTSAMLLYCTSCGANPSHYLC 256
            .|:           |||   ...|..|  :|....|    |..:|....|.        |..|.|
Mouse  1727 TGL-----------EPDVINVLIGSIR--INSLGTL----SDLSDCEGRLF--------PIGYQC 1766

  Fly   257 ------TLKTLQN--YVCKVCS--AVSPEAVPV----AESDSDDAGSMDDSAEAPRPGHL----- 302
                  |:...:.  |.|::..  ...|...||    ||.:.....|...|:|.|....|
Mouse  1767 SRLYWSTVDARRRCWYRCRILEYRPWGPREEPVHLEAAEENQTIVHSPTPSSEPPNHDDLPDTDS 1831

  Fly   303 --NGDQIQ----EKLSPSHWDDFGSSDDDAVFQRAFD---------------------------- 333
              .||.:.    :.|.|....|  ||:......|:|.
Mouse  1832 LIPGDPVHHSPIQNLDPPLRTD--SSNGPPPTPRSFSGARIKVPNYSPSRRPLGGVSFGPLPSPG 1894

  Fly   334 --TKVQSRVVTLSD-DQPSTSAGARALADRGTRTFESQGTQTTFLSSV---VTSFRSATA-TATS 391
              :.:...:.|:.| |.|:....:|..:...||...|:.|.:...:|.   |....|.|| |.||
Mouse  1895 SPSSLTHHIPTVGDSDFPAPPRRSRRPSPLATRPPPSRRTSSPLRTSPQLRVPLSTSVTALTPTS 1959

  Fly   392 STSTSTSTSASTLDNQENTEPSTSN-------------------GRRPWRPRYV----------- 426
            ........:.|.|...|:..|...:                   |..|::...|
Mouse  1960 GELAPPDLAPSPLPPSEDLGPDFEDMEVVSGLSAADLDFAASLLGTEPFQEEIVAAGAVGSSQGG 2024

  Fly   427 ---------SPPRH--------VS------------------DSDDDSDEYDSDEYESKRRQLTP 456
                     ||..|        ||                  |..||..:.:::..:..|.|.||
Mouse  2025 PGDSSEEEASPTTHYVHFPVTVVSGPALAPSSLAGAPRIEQLDGVDDGTDSEAEAVQQPRGQGTP 2089

  Fly   457 TAAAPSNGR-RLLGSISPEPSTP 478
             .:.|..|| .:||:.......|
Mouse  2090 -PSGPGVGRGGVLGAAGDRAQPP 2111

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Phf7	NP_608374.1	ePHD_PHF7_G2E3_like	5..116	CDD:277139	33/115 (29%)
		RING_Ubox	129..183	CDD:473075	11/53 (21%)
Kmt2b	NP_001277502.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..65
		Menin-binding motif (MBM). /evidence=ECO:0000250|UniProtKB:Q9UMN6	17..36
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	82..524
		PHA03378	<483..>702	CDD:223065
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	542..783
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	831..872
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	899..964
		zf-CXXC	963..1010	CDD:366873
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1032..1076
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1088..1138
		PHD1_KMT2B	1209..1255	CDD:277064
		PHD2_KMT2B	1257..1306	CDD:277066
		PHD3_KMT2B	1343..1399	CDD:277068
		Bromo_ALL-1	1380..1522	CDD:99925
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1550..1572
		ePHD_KMT2B	1587..1691	CDD:277164	33/115 (29%)
		FYRN	1739..1786	CDD:461787	13/60 (22%)
		PHA03307	1814..>2193	CDD:223039	55/301 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2065..2113		13/48 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2125..2169
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2288..2365
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2391..2417
		FYRC	2420..2504	CDD:197781
		WDR5 interaction motif (WIN). /evidence=ECO:0000250|UniProtKB:Q9UMN6	2515..2520
		SET_KMT2A_2B	2569..2722	CDD:380947