DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phf7 and Kmt2b

DIOPT Version :9

Sequence 1:	NP_001259740.1	Gene:	Phf7 / 33015	FlyBaseID:	FBgn0031091	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001277502.1	Gene:	Kmt2b / 75410	MGIID:	109565	Length:	2722	Species:	Mus musculus

Alignment Length:	613	Identity:	123/613 - (20%)
Similarity:	184/613 - (30%)	Gaps:	227/613 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 CVLCLS-GERDELIFG-TVHVEGNMMVHRNCLYLSSNLIQRGEKKLSIMNFLKEDIEAEVNRCRL 67
            |.|||. |:.|....| .:::..|...|.||...|:.:.:..:..|       :::.|.|.|.|.
Mouse  1587 CALCLKYGDADSKEAGRLLYIGQNEWTHVNCAIWSAEVFEENDGSL-------KNVHAAVARGRQ 1644

  Fly    68 LKCCYCRRLGANIWCCKSGCRRTFHTKCGVDNLAQNQFC---DTYNSFCHQHVLVPRNRPVFKND 129
            ::|..|.:.||.:.||.|.|...||..|     |:..:|   |....||.:|.
Mouse  1645 MRCELCLKPGATVGCCLSSCLSNFHFMC-----ARASYCIFQDDKKVFCQKHT------------ 1692

  Fly   130 EECLLCAEDVVAKGERFSVVTCLYAPCCRNGWFHRRCLQRYANSSGYFFKCPLCNNTDVFRRVAY 194
              .||..:::|.. :.|.|:              ||.   |.:..|..||           |...
Mouse  1693 --DLLDGKEIVTP-DGFDVL--------------RRV---YVDFEGINFK-----------RKFL 1726

  Fly   195 MGIAVLDQDASWETEPD---AFAGQYRRDVNCTAALCVAVSGRADTSAMLLYCTSCGANPSHYLC 256
            .|:           |||   ...|..|  :|....|    |..:|....|.        |..|.|
Mouse  1727 TGL-----------EPDVINVLIGSIR--INSLGTL----SDLSDCEGRLF--------PIGYQC 1766

  Fly   257 ------TLKTLQN--YVCKVCS--AVSPEAVPV----AESDSDDAGSMDDSAEAPRPGHL----- 302
                  |:...:.  |.|::..  ...|...||    ||.:.....|...|:|.|....|
Mouse  1767 SRLYWSTVDARRRCWYRCRILEYRPWGPREEPVHLEAAEENQTIVHSPTPSSEPPNHDDLPDTDS 1831

  Fly   303 --NGDQIQ----EKLSPSHWDDFGSSDDDAVFQRAFD---------------------------- 333
              .||.:.    :.|.|....|  ||:......|:|.
Mouse  1832 LIPGDPVHHSPIQNLDPPLRTD--SSNGPPPTPRSFSGARIKVPNYSPSRRPLGGVSFGPLPSPG 1894

  Fly   334 --TKVQSRVVTLSD-DQPSTSAGARALADRGTRTFESQGTQTTF---------LSSVVTSFRSAT 386
              :.:...:.|:.| |.|:....:|..:...||...|:.|.:..         ||:.||:.
Mouse  1895 SPSSLTHHIPTVGDSDFPAPPRRSRRPSPLATRPPPSRRTSSPLRTSPQLRVPLSTSVTAL---- 1955

  Fly   387 ATATSSTSTSTSTSASTLDNQENTEPSTSN-------------------GRRPWRPRYV------ 426
             |.||........:.|.|...|:..|...:                   |..|::...|
Mouse  1956 -TPTSGELAPPDLAPSPLPPSEDLGPDFEDMEVVSGLSAADLDFAASLLGTEPFQEEIVAAGAVG 2019

  Fly   427 --------------SPPRH--------VS------------------DSDDDSDEYDSDEYESKR 451
                          ||..|        ||                  |..||..:.:::..:..|
Mouse  2020 SSQGGPGDSSEEEASPTTHYVHFPVTVVSGPALAPSSLAGAPRIEQLDGVDDGTDSEAEAVQQPR 2084

  Fly   452 RQLTPTAAAPSNGR-RLLGSISPEPSTP 478
            .|.|| .:.|..|| .:||:.......|
Mouse  2085 GQGTP-PSGPGVGRGGVLGAAGDRAQPP 2111

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phf7	NP_001259740.1	ePHD_PHF7_G2E3_like	5..116	CDD:277139	33/115 (29%)
Kmt2b	NP_001277502.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..65
		Menin-binding motif (MBM). /evidence=ECO:0000250\|UniProtKB:Q9UMN6	17..36
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	82..524
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..783
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	831..872
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	899..964
		zf-CXXC	963..1010	CDD:251032
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1032..1076
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1088..1138
		PHD1_KMT2B	1209..1255	CDD:277064
		PHD2_KMT2B	1257..1306	CDD:277066
		PHD3_KMT2B	1343..1399	CDD:277068
		Bromo_ALL-1	1380..1522	CDD:99925
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1550..1572
		ePHD_KMT2B	1587..1691	CDD:277164	33/115 (29%)
		FYRN	1740..1786	CDD:283589	12/59 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2065..2113		13/48 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2125..2169
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2288..2365
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2391..2417
		FYRC	2420..2504	CDD:197781
		WDR5 interaction motif (WIN). /evidence=ECO:0000250\|UniProtKB:Q9UMN6	2515..2520
		SET	<2566..2722	CDD:225491
		SET	2584..2704	CDD:214614
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250\|UniProtKB:Q03164	2659..2660
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810