Protein Alignment Phf7 and KMT2A

DIOPT Version :9

• Sequence 1: NP_001259740.1
• Gene: Phf7 / 33015
• FlyBaseID: FBgn0031091
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: XP_011541131.1
• Gene: KMT2A / 4297
• HGNCID: 7132
• Length: 4005
• Species: Homo sapiens
• Alignment Length: 556
• Identity: 112/556 - (20%)
• Similarity: 196/556 - (35%)
• Gaps: 171/556 - (30%)

  Fly     5 CVLCLS-GERDELIFG-TVHVEGNMMVHRNCLYLSSNLIQRGEKKLSIMNFLKEDIEAEVNRCRL 67
            |.|||: |:......| .:::..|...|.||...|:.:.:..:..|       :::...|.|.:.
Human  1909 CALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSL-------KNVHMAVIRGKQ 1966

  Fly    68 LKCCYCRRLGANIWCCKSGCRRTFHTKCGVDNLAQN-QFCDTYNSFCHQHVLVPRNRPVFKNDEE 131
            |:|.:|::.||.:.||.:.|...:|..|   :.|:| .|.|....:|.:|
Human  1967 LRCEFCQKPGATVGCCLTSCTSNYHFMC---SRAKNCVFLDDKKVYCQRH--------------- 2013

  Fly   132 CLLCAEDVVAKGERFSVVTCLYAPCCRNGWFHRRCLQRYANSSGYFFKCPLCNNTDVFRR--VAY 194
                 .|:: |||   ||.       .||:                         :||||  |.:
Human  2014 -----RDLI-KGE---VVP-------ENGF-------------------------EVFRRVFVDF 2037

  Fly   195 MGIAVLDQDASWETEPD---AFAGQYRRDVNCTAALCVAV-SGRADTSAMLLYCTSCGANPSHYL 255
            .||::..:..: ..||:   ...|....|       |:.: :..:|....|.        |..|.
Human  2038 EGISLRRKFLN-GLEPENIHMMIGSMTID-------CLGILNDLSDCEDKLF--------PIGYQ 2086

  Fly   256 CT--------LKTLQNYVCKVCSAVSPEAVP--------------------VAESDSDDAGSMDD 292
            |:        .:....|.||:.....|...|                    ..||.|.::.:..:
Human  2087 CSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAE 2151

  Fly   293 SAEAP---RPGH--LNG-------DQIQEKLSPSHWDDFGSSDDDAVFQRAFDTKVQSRVVTLSD 345
            ....|   ||.|  .:|       .::....:||:.....|.....:......|.....:||:.|
Human  2152 IISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGD 2216

  Fly   346 DQPSTSAGARALADR--GTRTFESQGTQTTFLSSVVT----SFRSATATATSSTSTSTSTSASTL 404
              |..|:|.|::..|  .|.:...|.::...:|.:.|    |..:.::.:|:.|:|...:||..:
Human  2217 --PLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVV 2279

  Fly   405 DN-----------QENTEPSTSNGRRPWRPRYVSPPRHVSDSDDDSDEYDSDEYE--SKRRQLTP 456
            |:           .:||..| ||.:|    ..|:    |.:.:...|...|.|.:  |....::.
Human  2280 DHVLGPLNSSTSLGQNTSTS-SNLQR----TVVT----VGNKNSHLDGSSSSEMKQSSASDLVSK 2335

  Fly   457 TAAAPSNGRRLLGSISPE--------PSTP--APRV 482
            :::......::|.|.|.|        |..|  ||:|
Human  2336 SSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQV 2371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Phf7	NP_001259740.1	ePHD_PHF7_G2E3_like	5..116	CDD:277139	29/113 (26%)
KMT2A	XP_011541131.1	zf-CXXC	1180..1227	CDD:251032
		PHD1_KMT2A	1466..1512	CDD:277063
		PHD2_KMT2A	1514..1563	CDD:277065
		PHD3_KMT2A	1601..1660	CDD:277067
		Bromo_ALL-1	1683..1813	CDD:99925
		ePHD_KMT2A	1907..2019	CDD:277163	31/140 (22%)
		FYRN	2061..2107	CDD:283589	9/60 (15%)
		FYRC	3705..3788	CDD:197781
		SET	<3861..4005	CDD:225491
		SET	3867..3987	CDD:214614
		PostSET	3989..4005	CDD:214703

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810