DRSC/TRiP Functional Genomics Resources

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Protein Alignment Phf7 and KMT2A

DIOPT Version :10

Sequence 1:NP_608374.1 Gene:Phf7 / 33015 FlyBaseID:FBgn0031091 Length:520 Species:Drosophila melanogaster
Sequence 2:XP_011541131.1 Gene:KMT2A / 4297 HGNCID:7132 Length:4005 Species:Homo sapiens


Alignment Length:555 Identity:112/555 - (20%)
Similarity:196/555 - (35%) Gaps:169/555 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 CVLCLS-GERDELIFG-TVHVEGNMMVHRNCLYLSSNLIQRGEKKLSIMNFLKEDIEAEVNRCRL 67
            |.|||: |:......| .:::..|...|.||...|:.:.:..:..|       :::...|.|.:.
Human  1909 CALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSL-------KNVHMAVIRGKQ 1966

  Fly    68 LKCCYCRRLGANIWCCKSGCRRTFHTKCGVDNLAQN-QFCDTYNSFCHQHVLVPRNRPVFKNDEE 131
            |:|.:|::.||.:.||.:.|...:|..|   :.|:| .|.|....:|.:|               
Human  1967 LRCEFCQKPGATVGCCLTSCTSNYHFMC---SRAKNCVFLDDKKVYCQRH--------------- 2013

  Fly   132 CLLCAEDVVAKGERFSVVTCLYAPCCRNGWFHRRCLQRYANSSGYFFKCPLCNNTDVFRR--VAY 194
                 .|:: |||   ||.       .||:                         :||||  |.:
Human  2014 -----RDLI-KGE---VVP-------ENGF-------------------------EVFRRVFVDF 2037

  Fly   195 MGIAVLDQDASWETEPD---AFAGQYRRDVNCTAALCVAVSGRADTSAMLLYCTSCGANPSHYLC 256
            .||::..:..: ..||:   ...|.  ..::|...|    :..:|....|.        |..|.|
Human  2038 EGISLRRKFLN-GLEPENIHMMIGS--MTIDCLGIL----NDLSDCEDKLF--------PIGYQC 2087

  Fly   257 T--------LKTLQNYVCKVCSAVSPEAVP--------------------VAESDSDDAGSMDDS 293
            :        .:....|.||:.....|...|                    ..||.|.::.:..:.
Human  2088 SRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEI 2152

  Fly   294 AEAP---RPGH--LNG-------DQIQEKLSPSHWDDFGSSDDDAVFQRAFDTKVQSRVVTLSDD 346
            ...|   ||.|  .:|       .::....:||:.....|.....:......|.....:||:.| 
Human  2153 ISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGD- 2216

  Fly   347 QPSTSAGARALADR--GTRTFESQGTQTTFLSSVVT----SFRSATATATSSTSTSTSTSASTLD 405
             |..|:|.|::..|  .|.:...|.::...:|.:.|    |..:.::.:|:.|:|...:||..:|
Human  2217 -PLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVD 2280

  Fly   406 N-----------QENTEPSTSNGRRPWRPRYVSPPRHVSDSDDDSDEYDSDEYE--SKRRQLTPT 457
            :           .:||..| ||.:|    ..|:    |.:.:...|...|.|.:  |....::.:
Human  2281 HVLGPLNSSTSLGQNTSTS-SNLQR----TVVT----VGNKNSHLDGSSSSEMKQSSASDLVSKS 2336

  Fly   458 AAAPSNGRRLLGSISPE--------PSTP--APRV 482
            ::......::|.|.|.|        |..|  ||:|
Human  2337 SSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQV 2371

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Phf7NP_608374.1 ePHD_PHF7_G2E3_like 5..116 CDD:277139 29/113 (26%)
RING_Ubox 129..183 CDD:473075 8/53 (15%)
KMT2AXP_011541131.1 zf-CXXC 1180..1227 CDD:366873
PHD1_KMT2A 1466..1512 CDD:277063
PHD2_KMT2A 1514..1563 CDD:277065
PHD3_KMT2A 1601..1660 CDD:277067
Bromo_ALL-1 1683..1813 CDD:99925
ePHD_KMT2A 1907..2019 CDD:277163 31/140 (22%)
FYRN 2060..2107 CDD:461787 10/60 (17%)
FYRC 3705..3788 CDD:197781
SET_KMT2A_2B 3852..4005 CDD:380947
Blue background indicates that the domain is not in the aligned region.

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