DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phf7 and trx

DIOPT Version :9

Sequence 1:	NP_001259740.1	Gene:	Phf7 / 33015	FlyBaseID:	FBgn0031091	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_476769.1	Gene:	trx / 41737	FlyBaseID:	FBgn0003862	Length:	3726	Species:	Drosophila melanogaster

Alignment Length:	557	Identity:	107/557 - (19%)
Similarity:	172/557 - (30%)	Gaps:	163/557 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 QICVLC------LSGERDELIFGTVHVEGNMMVHRNCLYLSSNLIQRGEKKLSIMNFLKEDIEAE 61
            ::|:.|      ||||...|::    ...:..||.||...|:.:.:..:..|       :::.:.
  Fly  1735 RMCLFCRKSGEGLSGEEARLLY----CGHDCWVHTNCAMWSAEVFEEIDGSL-------QNVHSA 1788

  Fly    62 VNRCRLLKCCYCRRLGANIWCCKSGCRRTFHTKC--GVDNLAQNQFCDTYNSFCHQHVLVPRNRP 124
            |.|.|::||..|...||.:.|....|...:|..|  .:|    ..|....:.:|..|.
  Fly  1789 VARGRMIKCTVCGNRGATVGCNVRSCGEHYHYPCARSID----CAFLTDKSMYCPAHA------- 1842

  Fly   125 VFKNDEECLLCAEDVVAKGERFSVVTCLYAPCCRNG---------WFHRRCLQRYANSSGYFFKC 180
              ||...........|.....|.|...:|....|..         .||...|:
  Fly  1843 --KNGNALKANGSPSVTYESNFEVSRPVYVELDRKRKKLIEPARVQFHIGSLE------------ 1893

  Fly   181 PLCNNTDVFRRVAYMGIAVLDQDASWETEPDAFAGQYRRDVNCTAALCVAV--SGRADTSAMLLY 243
                       |..:|..|           ..|:..|...|... .||..:  |.:.....:...
  Fly  1894 -----------VRQLGAIV-----------PRFSDSYEAVVPIN-FLCSRLYWSSKEPWKIVEYT 1935

  Fly   244 CTSCGANPSHYLCTLKTLQNYVCKVCSAVSPEA-----------VPVAESDSDDAGSMDDSAEAP 297
            ..:...|.|..|..|...:||.....:..|.|.           ..:|.|:..:.|..|.|.|.|
  Fly  1936 VRTTIQNSSSTLTALDVGRNYTVDHTNPNSKEVQLGMAQIARWHTSLARSEFLENGGTDWSGEFP 2000

  Fly   298 RPG-------------HLNGDQIQEKLSPSHWDDF------GSS-------DDD----AVFQRAF 332
            .|.             ....|.:..:|..:.::|.      |.|       ||.    |:.:::.
  Fly  2001 NPNSCVPPDENTEEEPQQQADLLPPELKDAIFEDLPHELLDGISMLDIFLYDDKTDLFAISEQSK 2065

  Fly   333 D-TKVQSRVVTLSDDQPSTSAGARALADRGTRTFE---------SQGTQTTFLSSVVTSFR---- 383
            | |:..:.....:.:|.:..|.:.::.|..||...         |...:...||:...|.:
  Fly  2066 DGTQAMTSNQAQNQNQQAGGANSVSICDEDTRNSNTSLGNGWPASNPVEDAMLSAARNSSQVQML 2130

  Fly   384 -----------SATATATSSTSTSTSTSAS---TLDNQENT--EPSTSNGRRPWRPRYVSPPRHV 432
                       ||.|||......|.:.:..   ||.:|:..  |.:|..|        ||..:.:
  Fly  2131 KTLAWPKLDGNSAMATAIKRRKLSKNLAEGVFLTLSSQQRNKKEMATVAG--------VSRRQSI 2187

  Fly   433 SDSDDDSDEYDSDEYESKRRQLTPTAA----APSNGR 465
            |::..:.....|....||  ..|.:||    ..|.||
  Fly  2188 SETSVEGVATTSGSVRSK--SFTWSAAKRYFEKSEGR 2222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phf7	NP_001259740.1	ePHD_PHF7_G2E3_like	5..116	CDD:277139	28/118 (24%)
trx	NP_476769.1	NR_DBD_like	762..>856	CDD:295381
		PHD1_KMT2A_like	1268..1344	CDD:276981
		PHD	1346..1390	CDD:214584
		PHD3_KMT2A_like	1423..1479	CDD:276983
		ePHD_KMT2A_like	1737..1841	CDD:277134	28/118 (24%)
		FYRN	1891..1935	CDD:283589	10/78 (13%)
		FYRC	3388..3476	CDD:197781
		SET	3590..3710	CDD:214614
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1084
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810