Protein Alignment Phf7 and Kmt2a

DIOPT Version :9

• Sequence 1: NP_001259740.1
• Gene: Phf7 / 33015
• FlyBaseID: FBgn0031091
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: XP_038938273.1
• Gene: Kmt2a / 315606
• RGDID: 1586165
• Length: 3986
• Species: Rattus norvegicus
• Alignment Length: 629
• Identity: 123/629 - (19%)
• Similarity: 206/629 - (32%)
• Gaps: 182/629 - (28%)

  Fly     5 CVLCL------SGERDELIFGTVHVEGNMMVHRNCLYLSSNLIQRGEKKLSIMNFLKEDIEAEVN 63
            |.|||      :.:...|::    :..|...|.||...|:.:.:..:..|       :::...|.
  Rat  1894 CALCLMYGDDSANDAGRLLY----IGQNEWTHVNCALWSAEVFEDDDGSL-------KNVHMAVI 1947

  Fly    64 RCRLLKCCYCRRLGANIWCCKSGCRRTFHTKCGVDNLAQN-QFCDTYNSFCHQH------VLVPR 121
            |.:.|:|.:|::.||.:.||.:.|...:|..|   :.|:| .|.|....:|.:|      .:||.
  Rat  1948 RGKQLRCEFCQKPGATVGCCLTSCTSNYHFMC---SRAKNCVFLDDKKVYCQRHRDLIKGEVVPE 2009

  Fly   122 N-----RPVFKNDE--------------------------ECLLCAEDVVAKGERFSVVTCLYAP 155
            |     |.||.:.|                          :||....|:....::...:.   ..
  Rat  2010 NGFEVFRRVFVDFEGISLRRKFLNGLEPESVHVMIGSMTIDCLGILNDLSDCEDKLFPIG---YQ 2071

  Fly   156 CCRNGW----FHRRCLQRYANSSGYFFKCPLCN----NTDVFRRVAYMGIAVLDQDASWETEPDA 212
            |.|..|    ..:||:        |..|...|.    ..|:...|.:      |.:.:....|.:
  Rat  2072 CSRVYWSTTDARKRCV--------YTCKIMECRPPVVEPDINSTVEH------DDNRTIAHSPSS 2122

  Fly   213 FAGQYRRDVNCTAALCVAVS-----GRADTSAMLLYCTSCG-----ANPSHYLCTLKTLQNYVCK 267
            |.....:|...|||:....|     .:|.:|.   ||....     ..||:    ..|.::..|:
  Rat  2123 FIEASCKDSQSTAAILSPPSPDRPRSQASSSC---YCHVISKVPRIRTPSY----SPTQRSPGCR 2180

  Fly   268 -VCSAVSP-----EAV----PVAESDSDDAGSMDDSAEAPRP--------GHLNGDQIQEKLSPS 314
             :.||.||     |.|    |:..|.....||...|..:..|        ..:....:..:.|.|
  Rat  2181 PLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPLRSKLRIMSPVRSGSVYSRSSVS 2245

  Fly   315 HWDDFGSSDDDAVFQRAFD-TKVQSRVVTLSDDQPSTSAGARALADRGTRTFESQGTQTTFLSSV 378
            .....|::.|.....:|.| ....:....|....|.:|...|.:...|::|....|:.::.:...
  Rat  2246 SVPSLGTATDPESSAKATDRAGPLNSSANLGHSTPVSSGSQRTVVTGGSKTSHLDGSSSSGVKRS 2310

  Fly   379 VTSFRSATATATSSTSTSTSTSASTLDNQENT-----------------------------EPST 414
            ..|..:...::.......|..|.||..:..||                             ||||
  Rat  2311 SASDLAPKGSSLKGEKNRTPGSKSTDGSAHNTAYSGIPKLAPQVLNAAPGELNVSKIGTFAEPST 2375

  Fly   415 SNGRRPWRPRYVSPPR-HVSDSDDDSDEY-DSDEYESKRRQLTPTAAAPSNGRRLLGSISPEPST 477
            .    |:....||.|: |:.....|.|:: ||.:                       |:.|.|:.
  Rat  2376 V----PFSKETVSYPQLHLRGQRSDRDQHMDSTQ-----------------------SVKPSPNE 2413

  Fly   478 PAP-RVLRRRTLANRPSSLANMDISCVANRTRHRLSNHMASRKD 520
            ... :.|:...:.:|||.|...    |.:.:|.|......|.|:
  Rat  2414 DGEIKTLKLPGMGHRPSILHEH----VGSSSRDRRQKGKKSSKE 2453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Phf7	NP_001259740.1	ePHD_PHF7_G2E3_like	5..116	CDD:277139	28/117 (24%)
Kmt2a	XP_038938273.1	zf-CXXC	1145..1192	CDD:366873
		PHD1_KMT2A	1451..1497	CDD:277063
		PHD2_KMT2A	1499..1548	CDD:277065
		PHD3_KMT2A	1586..1645	CDD:277067
		Bromo_ALL-1	1668..1798	CDD:99925
		ePHD_KMT2A	1892..2004	CDD:277163	29/123 (24%)
		FYRN	2045..2092	CDD:399155	9/57 (16%)
		FYRC	3686..3769	CDD:197781
		SET_KMT2A_2B	3833..3986	CDD:380947

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910