DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phf7 and G2e3

DIOPT Version :9

Sequence 1:	NP_001259740.1	Gene:	Phf7 / 33015	FlyBaseID:	FBgn0031091	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001161435.1	Gene:	G2e3 / 217558	MGIID:	2444298	Length:	739	Species:	Mus musculus

Alignment Length:	322	Identity:	107/322 - (33%)
Similarity:	163/322 - (50%)	Gaps:	39/322 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 CVLCLSGERDELIFG--TVHVEGNMMVHRNCLYLSSNLIQRGEKKLSIMNFLKEDIEAEVNRCRL 67
            ||.|...:.....:|  ..:.:.|..||..||.:||.:.|||:::..:..||.|||..||.|...
Mouse    14 CVFCRKNDDCPNKYGEKKTYEKWNFSVHYYCLLMSSGIWQRGKEEEGVYGFLIEDIRKEVQRASK 78

  Fly    68 LKCCYCRRLGANIWCCKSGCRRTFHTKCGVDNLAQNQFCDTYNSFCHQHVLVPRNRPV------- 125
            |||..|::.||:|.|....|:|::|..||:......||.|.:.|||.:|      |||
Mouse    79 LKCTVCKKNGASIGCVVPTCKRSYHLPCGLQKECIFQFTDNFASFCWKH------RPVQAITSNK 137

  Fly   126 FKNDEECLLCAEDVVAKGERFSVVTCLYAPCCRNGWFHRRCLQRYANSSG-YFFKCPLCNNTDVF 189
            :.:...|.:|.|.|    |.......|.:|||:|.||||.|||..|.::| :||:|.||||||:|
Mouse   138 YSSSLPCTICLEFV----EPIPTYNILQSPCCKNAWFHRDCLQVQAINAGVFFFRCTLCNNTDIF 198

  Fly   190 RR-VAYMGIAVLDQDASWETEPDAFAGQYRRDVNCTAALCVAVSGR----ADTSAMLLYCTSCGA 249
            :: :..|||.:.::|||||.|.:|:....:....|....|....||    .::...:..|.|||:
Mouse   199 QKEMLRMGIHIPEKDASWELEENAYQELLQSHDRCDIRRCHCKKGRDYNEPNSKWEVKRCQSCGS 263

  Fly   250 NPSHYLC-TLKTL-QNYVCKVCSAV--------SPEAVPVAESDS---DDAGSMDDSAEAPR 298
            :.:|..| :|::. ||:.|..|..:        :|:. |:|.|.:   .|....:.|::.||
Mouse   264 SGTHLACSSLQSWEQNWECLDCRRITYTSDFQKAPKH-PLANSTNVTVTDCLLEESSSKLPR 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phf7	NP_001259740.1	ePHD_PHF7_G2E3_like	5..116	CDD:277139	41/112 (37%)
G2e3	NP_001161435.1	ePHD_PHF7_G2E3_like	14..127	CDD:277139	41/112 (37%)
		PHD_PHF7_G2E3_like	232..285	CDD:276971	14/52 (27%)
		HECTc	388..704	CDD:294058
		HECTc	411..713	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003998
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106451
Panther	1	1.100	-	-	LDO	PTHR12420
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10820
SonicParanoid	1	1.000	-	-		X3283
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.840