Protein Alignment Phf7 and Kmt2a

DIOPT Version :10

• Sequence 1: NP_608374.1
• Gene: Phf7 / 33015
• FlyBaseID: FBgn0031091
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_001344478.1
• Gene: Kmt2a / 214162
• MGIID: 96995
• Length: 3966
• Species: Mus musculus
• Alignment Length: 633
• Identity: 124/633 - (19%)
• Similarity: 206/633 - (32%)
• Gaps: 191/633 - (30%)

  Fly     5 CVLCL------SGERDELIFGTVHVEGNMMVHRNCLYLSSNLIQRGEKKLSIMNFLKEDIEAEVN 63
            |.|||      :.:...|::    :..|...|.||...|:.:.:..:..|       :::...|.
Mouse  1875 CALCLMYGDDSANDAGRLLY----IGQNEWTHVNCALWSAEVFEDDDGSL-------KNVHMAVI 1928

  Fly    64 RCRLLKCCYCRRLGANIWCCKSGCRRTFHTKCGVDNLAQN-QFCDTYNSFCHQH------VLVPR 121
            |.:.|:|.:|::.||.:.||.:.|...:|..|   :.|:| .|.|....:|.:|      .:||.
Mouse  1929 RGKQLRCEFCQKPGATVGCCLTSCTSNYHFMC---SRAKNCVFLDDKKVYCQRHRDLIKGEVVPE 1990

  Fly   122 N-----RPVFKNDE--------------------------ECLLCAEDVVAKGERFSVVTCLYAP 155
            |     |.||.:.|                          :||....|:....::...:.   ..
Mouse  1991 NGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIG---YQ 2052

  Fly   156 CCRNGW----FHRRCLQRYANSSGYFFKCPLCN----NTDVFRRVAYMGIAVLDQDASWETEPDA 212
            |.|..|    ..:||:        |..|...|.    ..|:...|.:      |.:.:....|.:
Mouse  2053 CSRVYWSTTDARKRCV--------YTCKIMECRPPVVEPDINSTVEH------DDNRTIAHSPSS 2103

  Fly   213 FAGQYRRDVNCTAALCVAVS---GRADTSAMLLYCTSCGA----NPSHYLCTLKTLQNYVCK-VC 269
            |.....:|...|||:....|   ..:.||....|......    .||:    ..|.::..|: :.
Mouse  2104 FIDASCKDSQSTAAILSPPSPDRPHSQTSGSCYYHVISKVPRIRTPSY----SPTQRSPGCRPLP 2164

  Fly   270 SAVSP-----EAV----PVAESDSDDAGSMDDSAEAPRPGHLNGDQIQEKL-------------- 311
            ||.||     |.|    |:..|.....||...|..:..|       ::.||
Mouse  2165 SAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSP-------LRSKLRIMSPVRTGSAYSR 2222

  Fly   312 -SPSHWDDFGSSDDDAVFQRAFDT-KVQSRVVTLSDDQPSTSAGARALADRGTRTFESQGTQTTF 374
             |.|.....|::.|.....:|.|. .:.|....|....|.:|:..|.:.  |::|....|:..:.
Mouse  2223 SSVSSVPSLGTATDPEASAKASDRGGLLSSSANLGHSAPPSSSSQRTVG--GSKTSHLDGSSPSE 2285

  Fly   375 LSSVVTSFRSATATATSSTSTSTSTSASTLDNQENT----------------------------- 410
            :.....|......:........||:|.||..:..:|
Mouse  2286 VKRCSASDLVPKGSLVKGEKNRTSSSKSTDGSAHSTAYPGIPKLTPQVHNATPGELNISKIGSFA 2350

  Fly   411 EPSTSNGRRPWRPR-YVSPPR-HVSDSDDDSDEYDSDEYESKRRQLTPTAAAPSNGRRLLGSISP 473
            ||||.    |:..: .||.|: |:.....|.|::                ..||.      |:.|
Mouse  2351 EPSTV----PFSSKDTVSYPQLHLRGQRSDRDQH----------------MDPSQ------SVKP 2389

  Fly   474 EPSTPAP-RVLRRRTLANRPSSLANMDISCVANRTRHRLSNHMASRKD 520
            .|:.... :.|:...:.:|||.|...    :.:.:|.|......|.|:
Mouse  2390 SPNEDGEIKTLKLPGMGHRPSILHEH----IGSSSRDRRQKGKKSSKE 2433

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Phf7	NP_608374.1	ePHD_PHF7_G2E3_like	5..116	CDD:277139	28/117 (24%)
		RING_Ubox	129..183	CDD:473075	11/83 (13%)
Kmt2a	NP_001344478.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..106
		Menin-binding motif (MBM). /evidence=ECO:0000250|UniProtKB:Q03164	6..25
		Integrase domain-binding motif 1 (IBM1). /evidence=ECO:0000250|UniProtKB:Q03164	121..132
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	130..231
		Integrase domain-binding motif 2 (IBM2). /evidence=ECO:0000250|UniProtKB:Q03164	145..150
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	322..343
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	440..590
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	711..943
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	963..1003
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1034..1064
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1101..1161
		zf-CXXC	1144..1191	CDD:366873
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1196..1390
		PHD1_KMT2A	1432..1478	CDD:277063
		PHD2_KMT2A	1480..1529	CDD:277065
		PHD3_KMT2A	1567..1626	CDD:277067
		Interaction with histone H3K4me3. /evidence=ECO:0000250|UniProtKB:Q03164	1583..1599
		Bromo_ALL-1	1649..1779	CDD:99925
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1665..1714
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1807..1870
		ePHD_KMT2A	1873..1985	CDD:277163	29/123 (24%)
		FYRN	2026..2073	CDD:461787	9/57 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2147..2174		8/30 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2214..2339		21/126 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2371..2619		16/89 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2639..2673
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2709..2759
		9aaTAD. /evidence=ECO:0000250|UniProtKB:Q03164	2843..2851
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2958..3060
		Herpes_BLLF1	<3152..>3361	CDD:282904
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3164..3239
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3462..3640
		FYRC	3666..3749	CDD:197781
		WDR5 interaction motif (WIN). /evidence=ECO:0000250|UniProtKB:Q03164	3759..3764
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3782..3805
		SET_KMT2A_2B	3813..3966	CDD:380947