DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rab35 and RAB1A

DIOPT Version :9

Sequence 1:	NP_001188678.1	Gene:	Rab35 / 33014	FlyBaseID:	FBgn0031090	Length:	201	Species:	Drosophila melanogaster
Sequence 2:	NP_004152.1	Gene:	RAB1A / 5861	HGNCID:	9758	Length:	205	Species:	Homo sapiens

Alignment Length:	201	Identity:	109/201 - (54%)
Similarity:	143/201 - (71%)	Gaps:	8/201 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FDHLFKLLIIGDSGVGKSSLLIRFSDDTFSGSYITTIGVDFKIRTVDIEGMRVKLQIWDTAGQER 69
            :|:|||||:|||||||||.||:||:|||::.|||:||||||||||::::|..:||||||||||||
Human     8 YDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTIKLQIWDTAGQER 72

  Fly    70 FRTITSTYYRGTHGVIVVYDVTNGESFANVRRWLEEIQNNC-DVVKKVLVGNKNDDPDRKVVITE 133
            ||||||:||||.||:|||||||:.|||.||::||:||.... :.|.|:|||||.|...:|||...
Human    73 FRTITSSYYRGAHGIIVVYDVTDQESFNNVKQWLQEIDRYASENVNKLLVGNKCDLTTKKVVDYT 137

  Fly   134 DAQRFAKQMDIELFETSAKDNINVENMFLSITRQVLDHKLRTSPNE----QQKDTLHLKPNPKGS 194
            .|:.||..:.|...|||||:..|||..|:::..::   |.|..|..    .:|..:.::..|...
Human   138 TAKEFADSLGIPFLETSAKNATNVEQSFMTMAAEI---KKRMGPGATAGGAEKSNVKIQSTPVKQ 199

  Fly   195 KGGKCC 200
            .||.||
Human   200 SGGGCC 205

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab35	NP_001188678.1	Rab35	3..201	CDD:133310	109/201 (54%)
RAB1A	NP_004152.1	Rab1_Ypt1	10..175	CDD:206661	100/167 (60%)
		Effector region. /evidence=ECO:0000255	40..48		6/7 (86%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..205		5/26 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1149105at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920