DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rab35 and RAB43

DIOPT Version :9

Sequence 1:	NP_001188678.1	Gene:	Rab35 / 33014	FlyBaseID:	FBgn0031090	Length:	201	Species:	Drosophila melanogaster
Sequence 2:	NP_001191812.1	Gene:	RAB43 / 339122	HGNCID:	19983	Length:	212	Species:	Homo sapiens

Alignment Length:	200	Identity:	87/200 - (43%)
Similarity:	127/200 - (63%)	Gaps:	8/200 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FDHLFKLLIIGDSGVGKSSLLIRFSDDTFSGSYITTIGVDFKIRTVDIEGMRVKLQIWDTAGQER 69
            :|.||||:::||:.|||:.::.||....||....:||||||.::|::|:|.||||||||||||||
Human    15 YDFLFKLVLVGDASVGKTCVVQRFKTGAFSERQGSTIGVDFTMKTLEIQGKRVKLQIWDTAGQER 79

  Fly    70 FRTITSTYYRGTHGVIVVYDVTNGESFANVRRWLEEIQN--NCDVVKKVLVGNKNDDPDRKVVIT 132
            |||||.:|||..:|.|:.||:|...||.:|..|:|:::.  ..::| ::|:|||:|..:.:.|..
Human    80 FRTITQSYYRSANGAILAYDITKRSSFLSVPHWIEDVRKYAGSNIV-QLLIGNKSDLSELREVSL 143

  Fly   133 EDAQRFAKQMDIE-LFETSAKDNINVENMFLSI-TRQVLDHKLRTSPNEQQKDTLHLKPNPKGSK 195
            .:||..|:..||. ..||||||:.|||..||.: |..::.|   ..|...:|...|::.|.|...
Human   144 AEAQSLAEHYDILCAIETSAKDSSNVEEAFLRVATELIMRH---GGPLFSEKSPDHIQLNSKDIG 205

  Fly   196 GGKCC 200
            .|..|
Human   206 EGWGC 210

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab35	NP_001188678.1	Rab35	3..201	CDD:133310	86/199 (43%)
RAB43	NP_001191812.1	Rab19	16..180	CDD:133267	79/164 (48%)
RAB43	NP_001191812.1	Effector region. /evidence=ECO:0000250	47..55		4/7 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910