DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fd19B and foxh1

DIOPT Version :9

Sequence 1:	NP_608369.1	Gene:	fd19B / 33010	FlyBaseID:	FBgn0031086	Length:	260	Species:	Drosophila melanogaster
Sequence 2:	NP_571577.1	Gene:	foxh1 / 57930	ZFINID:	ZDB-GENE-000616-15	Length:	472	Species:	Danio rerio

Alignment Length:	167	Identity:	52/167 - (31%)
Similarity:	81/167 - (48%)	Gaps:	30/167 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 NSGSSFSSCSSSSSNS--------SSDSMAAKSN----AKPAFTYSALIVMAIWSSSEKRLTLSG 83
            ::|.:..||..:.:.:        .:.|...|.|    .||.::|.|:|.|.|.:|.||:||||.
Zfish    58 STGMAQDSCYRAKATNQGPWELQDGNSSGGKKKNYQRYPKPPYSYLAMIAMVIQNSPEKKLTLSE 122

  Fly    84 ICKWIADNFPYYRTRKSVWQNSIRHNLSLNPFFVRVPRALDDP----GRGHYWALDPYAEDLSIG 144
            |.|.|:..||:::.....|::|:|||||....||:|   |.||    |:|::|.::.....|.:
Zfish   123 ILKEISTLFPFFKGNYKGWRDSVRHNLSSYDCFVKV---LKDPGKPQGKGNFWTVEVNRIPLEL- 183

  Fly   145 ETTGRLRRSNWQQNTG-ARPKVTGHPYQRMPYYGHGH 180
                 |:|    |||. :|...|.......||...|:
Zfish   184 -----LKR----QNTAVSRQDETIFAQDLAPYIFQGY 211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fd19B	NP_608369.1	FH	58..135	CDD:238016	35/80 (44%)
foxh1	NP_571577.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..56
		FH	97..174	CDD:238016	35/79 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	211..246		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	261..360
		SMAD-interaction domain (SID)	339..465
		Fast/FoxH1 motif 1 (FM1)	357..361
		Fast/FoxH1 motif 2 (FM2)	367..373
		SMAD interaction motif (SIM)	428..448
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820