DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fd19B and foxh1

DIOPT Version :9

Sequence 1:	NP_608369.1	Gene:	fd19B / 33010	FlyBaseID:	FBgn0031086	Length:	260	Species:	Drosophila melanogaster
Sequence 2:	NP_001017084.1	Gene:	foxh1 / 549838	XenbaseID:	XB-GENE-1194372	Length:	515	Species:	Xenopus tropicalis

Alignment Length:	199	Identity:	57/199 - (28%)
Similarity:	93/199 - (46%)	Gaps:	39/199 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 SKH--NSGSSFSSCSSSSSNSSS----DSMAAKSN-------AKPAFTYSALIVMAIWSSSEKRL 79
            |.|  :.|:...||:.:.....|    ::::.||.       |||.::|.|:|.:.|.:|.||||
Frog    67 SMHGLSPGTQEGSCTQAEGTKDSLGGDETLSRKSKKKNYHRYAKPPYSYLAMIALVIQNSPEKRL 131

  Fly    80 TLSGICKWIADNFPYYRTRKSVWQNSIRHNLSLNPFFVRVPRALDDPG----RGHYWALDPYAED 140
            .||.|.|.::..||:::.....|::|||||||.|..|.:|   |.|||    :|::|.:|.....
Frog   132 KLSQILKEVSTLFPFFKGDYMGWKDSIRHNLSSNDCFKKV---LKDPGKPQAKGNFWTVDVSRIP 193

  Fly   141 LSIGETTGRLRRSNWQQNTGARPKVTGHPYQRM-PY----YGHGHGNGPY----IKAHSAYFPIM 196
            |...:.          |||......:.:..|.: ||    |.:.|....|    :.:|::..|:.
Frog   194 LDAMKL----------QNTALTRGGSDYFVQDLAPYILHNYKYEHNVVVYAPHHMPSHASSLPLA 248

  Fly   197 DHQH 200
            :..|
Frog   249 EDPH 252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fd19B	NP_608369.1	FH	58..135	CDD:238016	34/80 (43%)
foxh1	NP_001017084.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	55..103		8/35 (23%)
		FH	110..188	CDD:238016	34/80 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	307..399
		SMAD-interaction domain (SID)	377..503
		Fast/FoxH1 motif 1 (FM1). /evidence=ECO:0000255	402..406
		Fast/FoxH1 motif 2 (FM2). /evidence=ECO:0000255	412..418
		SMAD-interaction motif (SIM)	467..488
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920