DRSC/TRiP Functional Genomics Resources

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Protein Alignment fd19B and FOXK2

DIOPT Version :9

Sequence 1:NP_608369.1 Gene:fd19B / 33010 FlyBaseID:FBgn0031086 Length:260 Species:Drosophila melanogaster
Sequence 2:NP_004505.2 Gene:FOXK2 / 3607 HGNCID:6036 Length:660 Species:Homo sapiens


Alignment Length:196 Identity:68/196 - (34%)
Similarity:99/196 - (50%) Gaps:35/196 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 SVDKKEESPISKHNSGSSF--------SSCSSSSSNS-------SSDSMAAKSNAKPAFTYSALI 67
            ::......|.|...:|||.        |..:..:.||       :|...:.|.::||.::|:.||
Human   203 TISAANSCPSSPRGAGSSGYKVGRVMPSDLNLMADNSQPENEKEASGGDSPKDDSKPPYSYAQLI 267

  Fly    68 VMAIWSSSEKRLTLSGICKWIADNFPYYRTRKSVWQNSIRHNLSLNPFFVRVPRALDDPGRGHYW 132
            |.||..:.:|:|||:||...|..|:|||||....||||||||||||.:|::|||:.::||:|.:|
Human   268 VQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFW 332

  Fly   133 ALDPYAEDLSIGETTGRLRRSNWQQNTGARPKVTGHPYQRMPYYGHGHGNGP-------YIKAHS 190
            .:||.:|...| |...|.|          ||:  |.|..|.|.......:.|       .:.|||
Human   333 RIDPASESKLI-EQAFRKR----------RPR--GVPCFRTPLGPLSSRSAPASPNHAGVLSAHS 384

  Fly   191 A 191
            :
Human   385 S 385

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fd19BNP_608369.1 FH 58..135 CDD:238016 41/76 (54%)
FOXK2NP_004505.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..36
FHA 47..154 CDD:238017
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 85..104
Required for interaction with DVL2 and SUDS3. /evidence=ECO:0000269|PubMed:25805136 129..171
COG5025 <180..577 CDD:227358 68/196 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 203..260 11/56 (20%)
Forkhead 257..343 CDD:365978 44/85 (52%)
DNA-binding, major groove. /evidence=ECO:0000269|PubMed:16624804 300..318 13/17 (76%)
DNA-binding, minor groove. /evidence=ECO:0000269|PubMed:16624804 328..332 1/3 (33%)
DNA-binding, minor groove. /evidence=ECO:0000269|PubMed:16624804 348..353 3/14 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 359..407 6/27 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 610..632
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG2294
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1270467at2759
OrthoFinder 1 1.000 - - FOG0000010
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.820

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