DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fd19B and foxa3

DIOPT Version :9

Sequence 1:	NP_608369.1	Gene:	fd19B / 33010	FlyBaseID:	FBgn0031086	Length:	260	Species:	Drosophila melanogaster
Sequence 2:	NP_571374.1	Gene:	foxa3 / 30559	ZFINID:	ZDB-GENE-980526-423	Length:	441	Species:	Danio rerio

Alignment Length:	306	Identity:	89/306 - (29%)
Similarity:	128/306 - (41%)	Gaps:	69/306 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDTTPIFQSSFSIRSLLSVDKKEES--PISKHNS-GSSFSSCSSSSSNSSSDS-------MAAKS 55
            |..:|: .||.:..||..:.....:  |:|.:.| |...|..|..|..|.:.:       ..:.:
Zfish    77 MSLSPV-GSSLNPSSLTQLGSSASTLGPLSHYQSMGQPMSQISYPSPTSLNRTKEMPKPYRRSLT 140

  Fly    56 NAKPAFTYSALIVMAIWSSSEKRLTLSGICKWIADNFPYYRTRKSVWQNSIRHNLSLNPFFVRVP 120
            :|||.::|.:||.|||..|..|.|||:.|.:||.|.|||||..:..|||||||:||.|..||:|.
Zfish   141 HAKPPYSYISLITMAIQQSQSKMLTLNEIYQWIMDLFPYYRENQQRWQNSIRHSLSFNDCFVKVA 205

  Fly   121 RALDDPGRGHYWALDPYAEDL-------------SIGETTGRLRRSNWQQNTGARPKVT----GH 168
            |:.|.||:|.||||.|.:.::             .|.|..|  ::|:.:...|:..|.|    |.
Zfish   206 RSPDKPGKGSYWALHPNSGNMFENGCYLRRQKRFKIEEKAG--KKSSSKSQDGSSTKGTHSSEGM 268

  Fly   169 PYQRMPYYGHGHGNGPYIKAHSAYFPIMDHQHHAAMVQHYQA-------------MMHRYQM--- 217
            ..:..|..|.....    .|||      |..|..:..:..|.             ::|...:
Zfish   269 QEEHSPTTGSDGAE----SAHS------DSSHAGSTSEEQQRSLVQLDCPSQAPNLLHSSPVPIP 323

  Fly   218 ------MPHPHHHQH-QHQHQHPH------SHFIQQSKPLHIQEPY 250
                  ||....|.| |.....||      .|...|:.||...:|:
Zfish   324 SSVSASMPPSSSHLHSQGMGNSPHLLGSPMHHLDLQNDPLKSMDPH 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fd19B	NP_608369.1	FH	58..135	CDD:238016	43/76 (57%)
foxa3	NP_571374.1	Forkhead_N	17..142	CDD:254796	14/65 (22%)
		FH	143..231	CDD:214627	45/87 (52%)
		HNF_C	374..>408	CDD:286443
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910