DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fd19B and FOXD1

DIOPT Version :9

Sequence 1:	NP_608369.1	Gene:	fd19B / 33010	FlyBaseID:	FBgn0031086	Length:	260	Species:	Drosophila melanogaster
Sequence 2:	NP_004463.1	Gene:	FOXD1 / 2297	HGNCID:	3802	Length:	465	Species:	Homo sapiens

Alignment Length:	216	Identity:	77/216 - (35%)
Similarity:	97/216 - (44%)	Gaps:	41/216 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 SSSNSSSDSMAAKSNAKPAFTYSALIVMAIWSSSEKRLTLSGICKWIADNFPYYRTRKSVWQNSI 106
            :....|:.|.|.....||.::|.|||.|||..|.:||||||.||::|:..|||||.:...|||||
Human   109 AGGGGSAGSGAKNPLVKPPYSYIALITMAILQSPKKRLTLSEICEFISGRFPYYREKFPAWQNSI 173

  Fly   107 RHNLSLNPFFVRVPRALDDPGRGHYWALDPYAEDL-SIGETTGRLRRSNWQ-------------- 156
            |||||||..||::||...:||:|:||.|||.:.|: ..|....|.:|...|
Human   174 RHNLSLNDCFVKIPREPGNPGKGNYWTLDPESADMFDNGSFLRRRKRFKRQPLLPPNAAAAESLL 238

  Fly   157 -QNTGA----------------RPKVTGHPYQRMPY-YGHGHGNGPYIKAHSAYFPIMDHQHHAA 203
             :..||                .|....|.|...|| .|:|....||... ||.|.       ||
Human   239 LRGAGAAGGAGDPAAAAALFPPAPPPPPHAYGYGPYGCGYGLQLPPYAPP-SALFA-------AA 295

  Fly   204 MVQHYQAMMHRYQMMPHPHHH 224
            ......|..|.:...|.|..|
Human   296 AAAAAAAAFHPHSPPPPPPPH 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fd19B	NP_608369.1	FH	58..135	CDD:238016	45/76 (59%)
FOXD1	NP_004463.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..117		1/7 (14%)
		Forkhead	125..211	CDD:278670	49/85 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	391..410
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820