DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fd19B and Foxk1

DIOPT Version :9

Sequence 1:	NP_608369.1	Gene:	fd19B / 33010	FlyBaseID:	FBgn0031086	Length:	260	Species:	Drosophila melanogaster
Sequence 2:	NP_951031.2	Gene:	Foxk1 / 17425	MGIID:	1347488	Length:	719	Species:	Mus musculus

Alignment Length:	166	Identity:	61/166 - (36%)
Similarity:	93/166 - (56%)	Gaps:	27/166 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 IRSLLS--------VDKKEESPISKHNSGSS-----------------FSSCSSSSSNS-SSDSM 51
            :|||:|        :......|.|...:|||                 |::.::|...: :|...
Mouse   220 LRSLVSPIPSPTGTISVPNSCPASPRGAGSSSYRFVQNVTSDLQLAAEFAAKAASEQQADASGGD 284

  Fly    52 AAKSNAKPAFTYSALIVMAIWSSSEKRLTLSGICKWIADNFPYYRTRKSVWQNSIRHNLSLNPFF 116
            :.|..:||.::|:.|||.||.|:.:::||||||...|..::|||||....||||||||||||.:|
Mouse   285 SPKDESKPPYSYAQLIVQAISSAQDRQLTLSGIYAHITKHYPYYRTADKGWQNSIRHNLSLNRYF 349

  Fly   117 VRVPRALDDPGRGHYWALDPYAEDLSIGETTGRLRR 152
            ::|||:.::||:|.:|.:|| |.:..:.|...|.||
Mouse   350 IKVPRSQEEPGKGSFWRIDP-ASEAKLVEQAFRKRR 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fd19B	NP_608369.1	FH	58..135	CDD:238016	41/76 (54%)
Foxk1	NP_951031.2	Interaction with SIN3A and SIN3B. /evidence=ECO:0000269\|PubMed:10620510, ECO:0000269\|PubMed:22476904	2..40
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..67
		Required for interaction with FOXO4 and MEF2C. /evidence=ECO:0000269\|PubMed:22956541	81..406		61/166 (37%)
		FHA	<88..190	CDD:224630
		FHA	96..189	CDD:238017
		Forkhead	291..377	CDD:278670	44/86 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	399..443
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	665..719
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820