Protein Alignment Dop2R and TAAR5

DIOPT Version :10

• Sequence 1: NP_001014758.2
• Gene: Dop2R / 33007
• FlyBaseID: FBgn0053517
• Length: 905
• Species: Drosophila melanogaster
• Sequence 2: NP_003958.2
• Gene: TAAR5 / 9038
• HGNCID: 30236
• Length: 337
• Species: Homo sapiens
• Alignment Length: 522
• Identity: 98/522 - (18%)
• Similarity: 146/522 - (27%)
• Gaps: 259/522 - (49%)

  Fly   387 ILTLFGNILVILSVCRERSLQTVTNYFIVSLAIADLLVAVVVMPFAVYFLVNGAWALPDVVCDFY 451
            ::.:.||:.|..:|...::|.|.||:.::|||:||:.:.::|:|.:....|...|...|.:|..:
Human    46 LIIVLGNVFVAFAVSYFKALHTPTNFLLLSLALADMFLGLLVLPLSTIRSVESCWFFGDFLCRLH 110

  Fly   452 IAMDVICSTSSIFNLVAISIDRYIAVTQPIKYAKHKNSRRVCLTILLV-WAISAAIGS------P 509
            ..:|.:...:|||:|..|||||:.|:..|:.|.. |.:.||.|..:|. |.:.||..|      .
Human   111 TYLDTLFCLTSIFHLCFISIDRHCAICDPLLYPS-KFTVRVALRYILAGWGVPAAYTSLFLYTDV 174

  Fly   510 IVLGLNNTPNREPDV--CAFYNADFILYSSLSSFYIPCIIMVFLYWNIFKALRSRARKQRAARKP 572
            :...|:......|.|  |......|..:.:...|::||:||:.||..||
Human   175 VETRLSQWLEEMPCVGSCQLLLNKFWGWLNFPLFFVPCLIMISLYVKIF---------------- 223

  Fly   573 HLSELTGGSVIENIAQTRRLAETALDSSRHASRILPDEAATNTASGSNEEEDENAISPDIDDCHV 637
                         :..||:
Human   224 -------------VVATRQ---------------------------------------------- 229

  Fly   638 IVNDKSTEFMLATVVEETGNSVVAQITTQPQLVVADPNGNHDSGYAASNVDDVLAGVAPASASAA 702
                                  ..||||                     :...|||
Human   230 ----------------------AQQITT---------------------LSKSLAG--------- 242

  Fly   703 TSAAPRSSGSPPDSPLPSGATLQRSSVSSQRRPTGDDSPKRGEPALRSVGVDNSSVAMKPLSFVR 767
                                                                             
Human   243 ----------------------------------------------------------------- 242

  Fly   768 YGVQEAMTLARNDSTLSTTSKTSSRKDKKNSQASRFTIYKVHKASKKKREKSSAKKERKATKTLA 832
                                                                :||.||||.|||.
Human   243 ----------------------------------------------------AAKHERKAAKTLG 255

  Fly   833 IVLGVFLFCWLPFFSCNIMDAMCAKFKKDCRPGLTAYMMTTWLGYINSFVNPVIYTIFNPEFRKA 897
            |.:|::|.|||||    .:|.|.........|.| .:.:..|..|.||..||:||......||||
Human   256 IAVGIYLLCWLPF----TIDTMVDSLLHFITPPL-VFDIFIWFAYFNSACNPIIYVFSYQWFRKA 315

  Fly   898 FK 899
            .|
Human   316 LK 317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop2R	NP_001014758.2	7tmA_D2-like_dopamine_R	376..>565	CDD:320181	55/186 (30%)
		TM helix 1	377..403	CDD:320181	4/15 (27%)
		TM helix 2	410..436	CDD:320181	9/25 (36%)
		TM helix 3	448..478	CDD:320181	12/29 (41%)
		TM helix 4	490..513	CDD:320181	8/29 (28%)
		TM helix 5	529..558	CDD:320181	10/28 (36%)
		7tm_GPCRs	<822..898	CDD:475119	31/75 (41%)
		TM helix 6	828..850	CDD:320181	11/21 (52%)
		TM helix 7	866..891	CDD:320181	9/24 (38%)
TAAR5	NP_003958.2	7tmA_TAAR5	35..316	CDD:320441	96/519 (18%)
		TM helix 1	36..62	CDD:320441	4/15 (27%)
		TM helix 2	69..95	CDD:320441	9/25 (36%)
		TM helix 3	107..137	CDD:320441	12/29 (41%)
		TM helix 4	149..172	CDD:320441	8/22 (36%)
		Extracellular Loop 2 (ECL2). /evidence=ECO:0000250|UniProtKB:Q5QD04	176..189		2/12 (17%)
		TM helix 5	196..225	CDD:320441	10/57 (18%)
		TM helix 6	245..275	CDD:320441	18/33 (55%)
		TM helix 7	284..309	CDD:320441	9/25 (36%)