Protein Alignment Dop2R and taar12j

DIOPT Version :10

• Sequence 1: NP_001014758.2
• Gene: Dop2R / 33007
• FlyBaseID: FBgn0053517
• Length: 905
• Species: Drosophila melanogaster
• Sequence 2: NP_001076380.1
• Gene: taar12j / 795139
• ZFINID: ZDB-GENE-041014-59
• Length: 340
• Species: Danio rerio
• Alignment Length: 549
• Identity: 114/549 - (20%)
• Similarity: 170/549 - (30%)
• Gaps: 261/549 - (47%)

  Fly   363 LTDSC---GELRVVDHNYWALILILFPILTLFGNILVILSVCRERSLQTVTNYFIVSLAIADLLV 424
            |:|||   ..|..:....:| .::|..:.|:|||:|:|:|:...:.||:.|:..:.|||.:|.|:
Zfish    20 LSDSCPRTQRLTALTVTMYA-FMVLMILTTVFGNLLIIISISHFKQLQSPTHLIVRSLAASDCLL 83

  Fly   425 AVVVMPFAVYFLVNGAWALPDVVCDFYIAMDVICSTSSIFNLVAISIDRYIAVTQPIKYAKHKNS 489
            ..:|||:::...|.|.|.|.||||..:.::|:..|.||:.:|..:|:|||.|:..|::|.....:
Zfish    84 GSLVMPYSMVRSVEGCWYLGDVVCKVHSSLDMTFSISSLIHLSLVSVDRYWAICDPLRYRMRVTN 148

  Fly   490 RRVCLTILLVWAISAAIGSPIVLGLNNTPNREPDV--------CA-FYNADFILYSSLSSFYIPC 545
            ..|.:..:..|..|......:|....|....|..:        |. |:|..:.|..||.:|::||
Zfish   149 NTVIVFTVFTWLFSFVYSFSVVFSGVNRIGLETFIMQVYCVGSCVLFFNKQWGLICSLLTFFLPC 213

  Fly   546 IIMVFLYWNIFKALRSRARKQRAARKPHLSE-LTGGSVIENIAQTRRLAETALDSSRHASRILPD 609
            .||..||..||...|..|:.        :|| :|||
Zfish   214 TIMSSLYMKIFHVARKHAKV--------MSERVTGG----------------------------- 241

  Fly   610 EAATNTASGSNEEEDENAISPDIDDCHVIVNDKSTEFMLATVVEETGNSVVAQITTQPQLVVADP 674
                                                                             
Zfish   242 ----------------------------------------------------------------- 241

  Fly   675 NGNHDSGYAASNVDDVLAGVAPASASAATSAAPRSSGSPPDSPLPSGATLQRSSVSSQRRPTGDD 739
                                                                             
Zfish   242 ----------------------------------------------------------------- 241

  Fly   740 SPKRGEPALRSVGVDNSSVAMKPLSFVRYGVQEAMTLARNDSTLSTTSKTSSRKDKKNSQASRFT 804
                    |:|
Zfish   242 --------LKS------------------------------------------------------ 244

  Fly   805 IYKVHKASKKKREKSSAKKERKATKTLAIVLGVFLFCWLPFFSCNIMDAMCAKFKKDCRPGLTAY 869
                         :|||::|.||.||||||:|||..||||||:...:|    .|.....| :..:
Zfish   245 -------------QSSAQREGKAAKTLAIVMGVFYLCWLPFFTATAVD----PFLNFSTP-VHVF 291

  Fly   870 MMTTWLGYINSFVNPVIYTIFNPEFRKAF 898
            ....|.||.||..||:||..|.|.|:|||
Zfish   292 DALVWFGYFNSTCNPLIYGFFYPRFQKAF 320

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop2R	NP_001014758.2	7tmA_D2-like_dopamine_R	376..>565	CDD:320181	63/197 (32%)
		TM helix 1	377..403	CDD:320181	9/25 (36%)
		TM helix 2	410..436	CDD:320181	9/25 (36%)
		TM helix 3	448..478	CDD:320181	11/29 (38%)
		TM helix 4	490..513	CDD:320181	4/22 (18%)
		TM helix 5	529..558	CDD:320181	13/28 (46%)
		7tm_GPCRs	<822..898	CDD:475119	34/75 (45%)
		TM helix 6	828..850	CDD:320181	15/21 (71%)
		TM helix 7	866..891	CDD:320181	9/24 (38%)
taar12j	NP_001076380.1	7tmA_TAAR2_3_4	35..320	CDD:320437	107/532 (20%)
		TM helix 1	36..62	CDD:320437	9/26 (35%)
		TM helix 2	69..95	CDD:320437	9/25 (36%)
		TM helix 3	107..137	CDD:320437	11/29 (38%)
		TM helix 4	149..172	CDD:320437	4/22 (18%)
		TM helix 5	197..226	CDD:320437	13/28 (46%)
		TM helix 6	249..279	CDD:320437	18/29 (62%)
		TM helix 7	288..313	CDD:320437	9/24 (38%)