Protein Alignment Dop2R and adra1bb

DIOPT Version :10

• Sequence 1: NP_001014758.2
• Gene: Dop2R / 33007
• FlyBaseID: FBgn0053517
• Length: 905
• Species: Drosophila melanogaster
• Sequence 2: NP_001007359.1
• Gene: adra1bb / 492486
• ZFINID: ZDB-GENE-041114-51
• Length: 481
• Species: Danio rerio
• Alignment Length: 589
• Identity: 152/589 - (25%)
• Similarity: 208/589 - (35%)
• Gaps: 248/589 - (42%)

  Fly   329 AITGSRGSGLL-------------LEQNLTGLYLDGYRLNCTNETLNLTDSCGELRVVDHNYWAL 380
            |:|.|.||.:|             |:.|.|||           |.|.|:      |.|.   ..|
Zfish     8 AVTRSWGSAILDAFEGSAVFPNFSLKLNGTGL-----------EPLLLS------RAVP---LGL 52

  Fly   381 ILILFPILTLFGNILVILSVCRERSLQTVTNYFIVSLAIADLLVAVVVMPFAVYFLVNGAWALPD 445
            :|..|....:.|||||||||...|.|::.||||||:|||||||:...|:|.:....|.|.|....
Zfish    53 VLGFFITFAIAGNILVILSVVCNRHLRSPTNYFIVNLAIADLLLGTTVLPVSATLEVVGHWVFGR 117

  Fly   446 VVCDFYIAMDVICSTSSIFNLVAISIDRYIAVTQPIKYAKHKNSRRVCLTILLVWAISAAIGSPI 510
            :.||.:.|:||:|.|:||.:|..|||||||.|:.|::|......||..|.:|.||.:|..|....
Zfish   118 IFCDVWAAVDVLCCTASIMSLCVISIDRYIGVSHPLQYPNIVTGRRALLAMLGVWVLSLVISIGP 182

  Fly   511 VLGLNNTPNREPDVCAFYNADF-ILYSSLSSFYIPCIIMVFLYWNIFKALRSRARKQRAARKPHL 574
            :||....|:.:..|||.....| .|:|||.|||||.|:::.:|..::
Zfish   183 LLGWKEPPSPDDTVCAINEEPFYALFSSLGSFYIPLIVILVMYCRVY------------------ 229

  Fly   575 SELTGGSVIENIAQTRRLAETALDSSRHASRILPDEAATNTASGSNEEEDENAISPDIDDCHVIV 639
                                                                             
Zfish   230 ----------------------------------------------------------------- 229

  Fly   640 NDKSTEFMLATVVEETGNSVVAQITTQPQLVVADPNGNHDSGYAASNVDDVLAGVAPASASAATS 704
                               |||:.||:                   |::   |||...|
Zfish   230 -------------------VVAKRTTK-------------------NLE---AGVKTES------ 247

  Fly   705 AAPRSSGSPPDSPLPSGATLQRSSVSSQRRPTGDDSPK-RGEPALRSVGVDNSSVAMKPLSFVRY 768
                         :.||....|....||   ..:|:.| |...|       .:|:.:|.|.|.|
Zfish   248 -------------MNSGEITLRIHRGSQ---VHEDAGKSRAHQA-------RNSLTVKLLKFSR- 288

  Fly   769 GVQEAMTLARNDSTLSTTSKTSSRKDKKNSQASRFTIYKVHKASKKKREKSSAKKERKATKTLAI 833
                                                                   |:||.|||.:
Zfish   289 -------------------------------------------------------EKKAAKTLGV 298

  Fly   834 VLGVFLFCWLPFFSCNIMDAMCAKFKKDCRPGLTAYMMTTWLGYINSFVNPVIYTIFNPEFRKAF 898
            |:|:|..||||||    :......|....||..|...:..||||.||.:||:||..::.||:.||
Zfish   299 VVGMFTLCWLPFF----LTLPIVSFNTSLRPPETVSSIIFWLGYFNSCLNPIIYPCYSREFKLAF 359

  Fly   899 KKIM 902
            .:|:
Zfish   360 IRIL 363

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop2R	NP_001014758.2	7tmA_D2-like_dopamine_R	376..>565	CDD:320181	78/189 (41%)
		TM helix 1	377..403	CDD:320181	12/25 (48%)
		TM helix 2	410..436	CDD:320181	15/25 (60%)
		TM helix 3	448..478	CDD:320181	17/29 (59%)
		TM helix 4	490..513	CDD:320181	8/22 (36%)
		TM helix 5	529..558	CDD:320181	12/29 (41%)
		7tm_GPCRs	<822..898	CDD:475119	31/75 (41%)
		TM helix 6	828..850	CDD:320181	12/21 (57%)
		TM helix 7	866..891	CDD:320181	11/24 (46%)
adra1bb	NP_001007359.1	7tm_GPCRs	48..359	CDD:475119	134/526 (25%)
		TM helix 1	50..74	CDD:410628	12/23 (52%)
		TM helix 2	83..105	CDD:410628	14/21 (67%)
		TM helix 3	121..143	CDD:410628	10/21 (48%)
		TM helix 4	166..182	CDD:410628	6/15 (40%)
		TM helix 5	203..226	CDD:410628	11/22 (50%)
		TM helix 6	293..315	CDD:410628	12/25 (48%)
		TM helix 7	327..352	CDD:410628	11/24 (46%)