DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dop2R and CG12290

DIOPT Version :9

Sequence 1:	NP_001014758.2	Gene:	Dop2R / 33007	FlyBaseID:	FBgn0053517	Length:	905	Species:	Drosophila melanogaster
Sequence 2:	NP_001287540.1	Gene:	CG12290 / 43182	FlyBaseID:	FBgn0039419	Length:	798	Species:	Drosophila melanogaster

Alignment Length:	700	Identity:	122/700 - (17%)
Similarity:	234/700 - (33%)	Gaps:	216/700 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   324 IAPGVAITGSRGSGLLLEQNLTG---------LYLDGYRLNCTN---ETLNLTDSCGELRVVDHN 376
            |.||:..|.:|.:..||..||.|         |.|.|.....:.   |||......|..:|:...
  Fly    27 ITPGLRTTANRFTINLLAINLIGCCILAPTLFLGLPGKSAEASTSNAETLEFFSKPGNHQVILRR 91

  Fly   377 YWALI----LILFPILTLFGNILVIL-----SVCRERSL-----------QTVTNYFIVSLAIAD 421
            ...|:    :::...::..|:.:...     :.|||.::           :|.|:        .:
  Fly    92 NGQLVEQDGVVVRRNISENGDTVETFFKCNATYCRELTIDERGDGGFVITETETH--------EE 148

  Fly   422 LLVAVVVMPFAVYFLVNGAWALPDVVCDFYIAMDVICSTSSIFNLVAISIDRYIAVTQPIKYAKH 486
            .|.|...:|       ..|..||.|....: ::|:..:..::..|:.:. |.:.|||.|::|...
  Fly   149 NLSAFESLP-------TEAPILPPVQLRCW-SIDMTAALGALAVLLVVG-DTWCAVTDPLRYHSR 204

  Fly   487 KNSRRVCLTILLVWAISAAIGSPIVLGLNNTPNREPDVCAFYNADF-------------ILYSSL 538
            .:..:..:.|.|.|.:....|:               :.||...||             :.|.::
  Fly   205 ISGVKTWIFIALTWVVGILFGA---------------LSAFRVLDFEADALFSRQRRLAVTYFNI 254

  Fly   539 SS------------FYIPCIIMVF-----LYWNIFKALRSRA-RKQRAARKPHLS---ELTGGSV 582
            ||            ::|..|::.|     :||.||...|... |.::....|.|.   .||.|
  Fly   255 SSTNSIFGVVYASVYFIVIILLPFGFVCGMYWRIFSEARGNGLRMRQNGSSPLLQSALNLTAG-- 317

  Fly   583 IENIAQTRRLAETALDSSRHASRILPDEAATNTASGSNEEEDENAISPDID---------DCHVI 638
             :..||..:.: .:|...||:       .::.::.|.|.......:...||         .|  :
  Fly   318 -QQAAQANQFS-NSLCVHRHS-------ISSASSHGGNSSLGLGGLQMQIDQRQQPRSSPSC--L 371

  Fly   639 VNDKSTEFMLATVVEETGNSVV--AQITTQP-------------QLVVADPNGNHDSGYAA---- 684
            ..|.:.:.:|.|:.::.|:...  |.:...|             .|.:...:|.....|:|
  Fly   372 RRDSAAKVLLPTISDDGGSDAESGAGVQLMPVQEHSLSDRNQNIMLTLQTASGEIKRNYSARQLP 436

  Fly   685 ----SNVD----DVLAGVAPASAS--------AATSAAPRSSGSPPDSPLPSGATLQRSSVSSQR 733
                |:.|    :.|.|:....:|        ....:.....|||  ..|......|:..:..|.
  Fly   437 LLGTSSQDLRETNRLQGIRQVHSSPNLHKYTELRQDSLSEECGSP--HLLGHAQRQQQQQLHLQH 499

  Fly   734 RPTGDDSPKRGEP------------ALRSVGVDNSSVAMKPLSFVRYGVQEAMTLARNDSTLSTT 786
            :.......::..|            ||:...:..|..|:..:|.:|:.:..|.:|.
  Fly   500 QQQQHHHHQQHHPHFSSPRHQQHGHALQIPAIHASPKALSYMSSLRHRLSNASSLF--------- 555

  Fly   787 SKTSSRKDKKNSQASRFTIYKVHKASKKKREKSSAKKERKATKTLAIVLGVFLFCWLPFFSCNIM 851
                  |.::.|:|:|.:|                           :|:.:|:..:|||....::
  Fly   556 ------KYREESRAARISI---------------------------LVVVMFVVSYLPFGLLVLL 587

  Fly   852 DAMCAKFKKDCRPGLTAYMMTTWLGYINSFVNPVIYTIFNPEFRKAFKKI 901
            .:..:.........|..:|:     .:.:..:|.|:...|...|:..|::
  Fly   588 QSRLSAANFGGSSQLAIFMI-----LLANLSSPFIFAYRNKRVRRGVKRL 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dop2R	NP_001014758.2	7tmA_D2-like_dopamine_R	376..>565	CDD:320181	41/239 (17%)
		TM helix 1	377..403	CDD:320181	3/34 (9%)
		TM helix 2	410..436	CDD:320181	4/25 (16%)
		TM helix 3	448..478	CDD:320181	4/29 (14%)
		TM helix 4	490..513	CDD:320181	4/22 (18%)
		TM helix 5	529..558	CDD:320181	12/58 (21%)
		7tm_GPCRs	<822..898	CDD:333717	11/75 (15%)
		TM helix 6	825..850	CDD:320095	5/24 (21%)
		TM helix 7	866..891	CDD:320095	4/24 (17%)
CG12290	NP_001287540.1	7tm_1	<190..>305	CDD:278431	26/129 (20%)
CG12290	NP_001287540.1	7tm_1	<537..617	CDD:278431	18/126 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24248
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100