DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dop2R and Octalpha2R

DIOPT Version :9

Sequence 1:	NP_001014758.2	Gene:	Dop2R / 33007	FlyBaseID:	FBgn0053517	Length:	905	Species:	Drosophila melanogaster
Sequence 2:	NP_001262715.1	Gene:	Octalpha2R / 42258	FlyBaseID:	FBgn0038653	Length:	740	Species:	Drosophila melanogaster

Alignment Length:	765	Identity:	208/765 - (27%)
Similarity:	317/765 - (41%)	Gaps:	226/765 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   261 PSTTSYDG-----GGSGDVGVAGGLAGTAGGGVGGAGGSGGSTFMLLLENFNDYFPNYNGSTVSG 320
            |...|.||     .|||.|.|        ...:....||..::.:.|...|      ||.|:.||
  Fly    36 PPLLSVDGQLTLPPGSGYVNV--------NDTIFFLNGSFYNSSLQLAAGF------YNQSSASG 86

  Fly   321 TSTIAPGVAITGSRGSGLLLEQNLT-----GLYLDGYRLNCTNETLNLTDSCGELRVVDHNYWAL 380
            .:             ||.|...|.|     |.|..||.|.                   |...|.
  Fly    87 AT-------------SGNLTNPNHTEVHWDGRYPSGYTLT-------------------HIVIAS 119

  Fly   381 ILI-LFPILTLFGNILVILSVCRERSLQTVTNYFIVSLAIADLLVAVVVMPFAVYFLVNGAWALP 444
            |:: :..|:.:.||:|||:::..|:||:.:.|:||.|||:||..:.:::|||::...:.|.|...
  Fly   120 IIVTILMIIIVVGNMLVIIAIATEKSLKNIQNWFIASLAVADFFLGLIIMPFSLANELMGYWIFG 184

  Fly   445 DVVCDFYIAMDVICSTSSIFNLVAISIDRYIAVTQPIKYAKHKNSRRVCLTILLVWAISAAIGSP 509
            ...||.:.||||:..|:||.||..||:|||.::|:.:.|.|.:...|..:.|..||.:||.|..|
  Fly   185 SWWCDIHSAMDVLLCTASIMNLCLISLDRYWSITKAVDYLKSRTPARAAVMITAVWIMSALICIP 249

  Fly   510 IVLGLN-NTPNREPDVCAF-YNADFILYSSLSSFYIPCIIMVFLYWNIFKALRSRARK--QRAAR 570
            .:||.. ..|......|.. .:..::|||:|.|||||..||||:|..|:.|.::|||:  ::..|
  Fly   250 PLLGWKVKMPEGPLPKCELSEDIGYVLYSALGSFYIPSCIMVFVYIRIYFAAKARARRGIKKHPR 314

  Fly   571 KPHLSELT----------------GGSVIENIAQTRRLA--ETALDSSRHASRILPDEAATNTAS 617
            |.:..::|                |.|.:: :.|.|::|  ||..:|:.     ||.:..|.|..
  Fly   315 KTNNEQVTSFTTAKKGTIPMPSSSGVSALQ-LHQQRQIATIETPPNSAS-----LPMQIPTVTMD 373

  Fly   618 GSNEEEDENAISPDIDDCHVIVNDKSTEFMLATVVEETGNSVVAQITTQPQLVVADPNGNHDSGY 682
                                :.:|.||        .|.|.  :..:..|..|..|:|||
  Fly   374 --------------------LASDIST--------SEAGE--LEAVAAQTVLAYANPNG------ 402

  Fly   683 AASNVDDVLAGVAPASASAATSAAPRSSGSPPDSPLPSGATLQRSSVSSQR-------------- 733
                     ||....:..::.:..|.:||.||.||   ..|||.|::::.|
  Fly   403 ---------AGTNSVTVVSSGNGGPGASGVPPSSP---KETLQVSTIATGRVGLNVPVPPSMGSN 455

  Fly   734 ------------------------------------RPTGDD----SPKRGEPALRSVGVDNSSV 758
                                                :.||.:    ||..|.....|||||...|
  Fly   456 SSINVLNNNNGTVAMDGGATAAGGGNGSAVATPGGLQQTGGNELRVSPIAGRCRALSVGVDTDMV 520

  Fly   759 A-----------------MKPLSF----VRYGVQEAMTLARNDSTLSTTSKTSSRKDKKNSQASR 802
            :                 :|||.|    ..:|.:.:....||::..:..::.||....||.|..:
  Fly   521 SEFDPSSSDSGVVSRCAVVKPLKFRLCQPIFGRKSSNQQRRNEAKAAAKNQQSSGVASKNQQQQQ 585

  Fly   803 F-------------TIYKVHKASKKKREKS--SAKKERKATKTLAIVLGVFLFCWLPFFSCNIMD 852
            .             .|.|..|....::||.  :.|||::||..|.:::|.|:.||||||...|:.
  Fly   586 QQQQQQVVKSELEPAIPKTPKPRDPEKEKRRIARKKEKRATLILGLIMGSFIACWLPFFFLYILV 650

  Fly   853 AMCAKFKKDCRPGLTAYMMTTWLGYINSFVNPVIYTIFNPEFRKAFKKIM 902
            ..|:   ..|....:|:.:..||||:||.:||.||||||.:||:||::|:
  Fly   651 PACS---SHCNIPESAFAVAFWLGYMNSALNPAIYTIFNKDFRRAFRRIL 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dop2R	NP_001014758.2	7tmA_D2-like_dopamine_R	376..>565	CDD:320181	73/191 (38%)
		TM helix 1	377..403	CDD:320181	8/26 (31%)
		TM helix 2	410..436	CDD:320181	11/25 (44%)
		TM helix 3	448..478	CDD:320181	16/29 (55%)
		TM helix 4	490..513	CDD:320181	8/22 (36%)
		TM helix 5	529..558	CDD:320181	15/28 (54%)
		7tm_GPCRs	<822..898	CDD:333717	34/75 (45%)
		TM helix 6	825..850	CDD:320095	11/24 (46%)
		TM helix 7	866..891	CDD:320095	13/24 (54%)
Octalpha2R	NP_001262715.1	7tm_1	132..>315	CDD:278431	71/182 (39%)
Octalpha2R	NP_001262715.1	7tm_4	133..>252	CDD:304433	47/118 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010