DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dop2R and TyrR

DIOPT Version :9

Sequence 1:	NP_001014758.2	Gene:	Dop2R / 33007	FlyBaseID:	FBgn0053517	Length:	905	Species:	Drosophila melanogaster
Sequence 2:	NP_001287381.1	Gene:	TyrR / 42136	FlyBaseID:	FBgn0038542	Length:	631	Species:	Drosophila melanogaster

Alignment Length:	686	Identity:	194/686 - (28%)
Similarity:	307/686 - (44%)	Gaps:	142/686 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 APSTTSYDGGGSGD-VGVAGGLA------------GTAGGGVGGAGGSGGSTFMLLLENFNDYFP 311
            |.|::|..|.|.|. ||| |||.            ||.||||||.||.              |..
  Fly    21 AASSSSLRGLGLGSGVGV-GGLPENISIVYEDAGNGTGGGGVGGVGGG--------------YPS 70

  Fly   312 NYNGSTVSGTSTIAPGVAITGSRGSGLLLEQNLTGLYLDGYRLNCTNETLNLTDSCGELRVVDHN 376
            ..||:.....:...|...:|                     ..|..||:....:..       |.
  Fly    71 GPNGTDAVALTEPGPTAPVT---------------------TFNYYNESAAAAEWA-------HF 107

  Fly   377 Y-----WALILIL-----FPILTLFGNILVILSVCRERSLQTVTNYFIVSLAIADLLVAVVVMPF 431
            |     |..|:::     |.::|:.||.||||::...|.|:|:||.|::|||:|||||.:.|||.
  Fly   108 YDLVLSWQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPP 172

  Fly   432 AVYFLVNGAWALPDVVCDFYIAMDVICSTSSIFNLVAISIDRYIAVTQPIKYAKHKNSRRVCL-T 495
            ||...:.|:|.|..|:||.:|::||:..|:||.:|.|||:|||:|||:|:.|::.:.|:|:.| .
  Fly   173 AVAVHLIGSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIM 237

  Fly   496 ILLVWAISAAIGSPIVLGLNNTPNREPDVCAF-YNADFILYSSLSSFYIPCIIMVFLYWNIFKAL 559
            ||:||.::.||..|.:||......|:...|.: .|..::::|::.||:||..:|:::|..|...:
  Fly   238 ILIVWLLALAITCPPMLGWYEPGRRDLRECRYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVI 302

  Fly   560 RSRARKQRAARKPHLSELTGGSVIENIAQTRRLA---ETALDSSRHASRILPDEAATNTASGSNE 621
                    |:|..::::::    :.|....|..|   |..|......|.:...:....:.:.||:
  Fly   303 --------ASRHDNMTDIS----VHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQ 355

  Fly   622 EEDENAISPDIDDCHVIVNDKSTEFMLATVVEETGNSVVAQITTQPQLVVADPNG--NHDSGYAA 684
                 .|:.::.|..:..:|..............|.:..|...|..|.::|.|:|  ....|.|.
  Fly   356 -----TIAKELQDMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAK 415

  Fly   685 SNVDDVLAGVAPAS----ASAATSAAPRSSGSPPDSPL--------PSGAT--LQRSSVSSQRRP 735
            :...::   ..|:|    ::|:|:....:||..|.|.|        |.|.|  :|..|:|
  Fly   416 NGCYEL---TRPSSLKRASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLS----- 472

  Fly   736 TGDDSPKRGEPALRSVGVDNSSVAMKPLSFVRYGVQEAMTLARNDSTLSTTSKTSSRKDKKNSQA 800
                .|.|......|.|..:............|..|..:|      |.||:..||:..:.| |.:
  Fly   473 ----QPPRTHSFRHSHGERDRERLRSHHHHPHYHHQAGVT------TTSTSGNTSANTNSK-SLS 526

  Fly   801 SRFTIYKVHKASKKKREKSSAKKERKATKTLAIVLGVFLFCWLPFFSCNIMDAMCAKFKKDCRPG 865
            :|.|               |.|||.|.|:||:||:|.|:.||||||    ::.:...|..:.:..
  Fly   527 NRIT---------------SLKKENKTTQTLSIVVGGFIACWLPFF----INYLITPFLAEHQAS 572

  Fly   866 LTAYMMTTWLGYINSFVNPVIYTIFNPEFRKAFKKI 901
            .......||||:.||.:||.||..::.:||.||.::
  Fly   573 QMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRL 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dop2R	NP_001014758.2	7tmA_D2-like_dopamine_R	376..>565	CDD:320181	77/200 (39%)
		TM helix 1	377..403	CDD:320181	11/35 (31%)
		TM helix 2	410..436	CDD:320181	16/25 (64%)
		TM helix 3	448..478	CDD:320181	16/29 (55%)
		TM helix 4	490..513	CDD:320181	9/23 (39%)
		TM helix 5	529..558	CDD:320181	9/28 (32%)
		7tm_GPCRs	<822..898	CDD:333717	30/75 (40%)
		TM helix 6	825..850	CDD:320095	14/24 (58%)
		TM helix 7	866..891	CDD:320095	10/24 (42%)
TyrR	NP_001287381.1	7tm_4	127..>249	CDD:304433	58/121 (48%)
TyrR	NP_001287381.1	7tm_1	133..>298	CDD:278431	71/164 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460677
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940