DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dop2R and TyrRII

DIOPT Version :9

Sequence 1:	NP_001014758.2	Gene:	Dop2R / 33007	FlyBaseID:	FBgn0053517	Length:	905	Species:	Drosophila melanogaster
Sequence 2:	NP_001262682.1	Gene:	TyrRII / 42135	FlyBaseID:	FBgn0038541	Length:	586	Species:	Drosophila melanogaster

Alignment Length:	653	Identity:	168/653 - (25%)
Similarity:	268/653 - (41%)	Gaps:	178/653 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   314 NGSTVSGT-----STIAPG--VAITGSRGSGLLLEQNLTGL-YLDGYRLNCTNETLNLTDSCGEL 370
            |.::..||     ::.|||  |..||: |:|.|      |: .::.|.::..
  Fly    27 NSNSSDGTLLLIQTSAAPGGDVMATGA-GAGKL------GVPSMNSYLVSMA------------- 71

  Fly   371 RVVDHNYW------ALILILFPILTLFGNILVILSVCRERSLQTVTNYFIVSLAIADLLVAVVVM 429
                   |      |:.|::. ::|:.||.||||:|...|.|:||||.|:::|||.|.||...||
  Fly    72 -------WPKSLAVAVFLVII-LVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVM 128

  Fly   430 PFAVYFLVNGAWALPDVVCDFYIAMDVICSTSSIFNLVAISIDRYIAVTQPIKYAKHKNSRRVC- 493
            |.:|...:.|.|....::||.:|::|::..:.||.:|.|||:|||:|||||:.|:|.:.|:|:.
  Fly   129 PPSVVLYITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLAL 193

  Fly   494 LTILLVWAISAAIGSPIVLGLNNTPNREPDV--CAF-YNADFILYSSLSSFYIPCIIMVFLYWNI 555
            |.||:||..:.:|..|..||.......:.:.  |.: .|..::::|::.||:||..:|:::|..|
  Fly   194 LMILVVWITALSITCPPYLGWYEVGRHQAEFVDCRYNQNKGYVVFSAMGSFFIPLTVMLYVYVKI 258

  Fly   556 FKALRSRARKQRAARKPHLSELTGGSVIENIAQTRRLAETALDSSRH----ASRILPD------- 609
            ...|.|  |:||..|..: ||.|....::        .:..:..|.|    .::.||:
  Fly   259 GYVLTS--RRQRIVRDAY-SERTADYDVD--------GDNFISESEHYHCTPTKWLPNRKSRWRF 312

  Fly   610 --------EAATNTASGSNEEEDENAISPDIDDCHVIVNDKSTEFMLATVVEETGNSVVAQITTQ 666
                    .||||.|:..::..              :...|.::...||
  Fly   313 NSLHDPPPSAATNAAAKGHQSS--------------VKCSKCSKCSSAT---------------- 347

  Fly   667 PQLVVADPNGNHDSGYAASNVDDV-----------LAGVAPASASAATSAAPRSSGSPPDSPLPS 720
                     |...:|..|..||..           |..|:..|:....||.....|.|.....||
  Fly   348 ---------GTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIHCSAISCKYGGPCMHSTPS 403

  Fly   721 GATLQRSSVSSQRRPTGDDSPKRGEPALRSVGVDNSSVAMKPLSFVRYGVQEAMTLARNDSTLST 785
            |.....:..|......|.:             |.|::.                |...|...|.|
  Fly   404 GMHYVGTEASFSDTCLGGN-------------VSNNTT----------------TTTTNTVALET 439

  Fly   786 TSKTSSR-KDKKNSQASRFTIYKVH--------------KASKKKREKSSAKKERKATKTLAIVL 835
            ..|..:. |.|:..|.|.|..:..|              ...:.....|:.|::.|..|||.||:
  Fly   440 NEKLEAEAKQKQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVM 504

  Fly   836 GVFLFCWLPFFSCNIMDAMCAKFKKDCRPGLTAYMM--TTWLGYINSFVNPVIYTIFNPEFRKAF 898
            |..:.||||||...::.....      ||.:...:|  .||:|::|..:||.||..:||:||.||
  Fly   505 GGLIACWLPFFVYYLLIPFLP------RPAVLEDLMFGFTWIGWVNCAINPFIYAFYNPDFRTAF 563

  Fly   899 KKI 901
            .::
  Fly   564 WRL 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dop2R	NP_001014758.2	7tmA_D2-like_dopamine_R	376..>565	CDD:320181	73/198 (37%)
		TM helix 1	377..403	CDD:320181	11/31 (35%)
		TM helix 2	410..436	CDD:320181	13/25 (52%)
		TM helix 3	448..478	CDD:320181	14/29 (48%)
		TM helix 4	490..513	CDD:320181	8/23 (35%)
		TM helix 5	529..558	CDD:320181	9/28 (32%)
		7tm_GPCRs	<822..898	CDD:333717	29/77 (38%)
		TM helix 6	825..850	CDD:320095	13/24 (54%)
		TM helix 7	866..891	CDD:320095	9/26 (35%)
TyrRII	NP_001262682.1	7tm_4	82..>212	CDD:304433	57/130 (44%)
TyrRII	NP_001262682.1	7tm_1	91..>277	CDD:278431	74/188 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460676
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940