DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dop2R and Octbeta2R

DIOPT Version :9

Sequence 1:	NP_001014758.2	Gene:	Dop2R / 33007	FlyBaseID:	FBgn0053517	Length:	905	Species:	Drosophila melanogaster
Sequence 2:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster

Alignment Length:	688	Identity:	168/688 - (24%)
Similarity:	242/688 - (35%)	Gaps:	257/688 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   252 RETLGNRTA-------PSTTSYDGGGSGDVGVAGGLAGTAGGGVGGAGGSGGS------------ 297
            |:...|||:       |.....|||       :|..|...||.|......|.|
  Fly    13 RQRHRNRTSAARIRKRPKCCCGDGG-------SGNQAEQPGGIVSNPISYGQSLTTLARVTAAAL 70

  Fly   298 TFMLLLENFNDYFPNYNGSTVSGTSTIAPGVAITGSRGSGLLLEQNLTGLYLDGYRLNCTNETLN 362
            |...:|...|..... ..|:.|.:||  .|:|:.....:....|.|.|..: .|..||.......
  Fly    71 TTAAMLHTTNALAAT-GSSSASNSST--GGIALPLGTATPATHELNATQPF-GGSGLNFNESGAG 131

  Fly   363 LTDSCGELR------VVDHNYW---ALILILFPILTLFGNILVILSVCRERSLQTVTNYFIVSLA 418
            |:|.....:      .:|:..|   |.:::|..|..:.||:|||:||.|.|.|:.:||||:||||
  Fly   132 LSDHHHHQQHNPDEDWLDNIVWVFKAFVMLLIIIAAICGNLLVIISVMRVRKLRVITNYFVVSLA 196

  Fly   419 IADLLVAVVVMPFAVYFLVNGAWALPDVVCDFYIAMDVICSTSSIFNLVAISIDRYIAVTQPIKY 483
            :||::||::.|.|.....|.|.|.....:||.:.::||..||:||.:|..||:|||.|:.:|:||
  Fly   197 MADIMVAIMAMTFNFSVQVTGRWNFSPFLCDLWNSLDVYFSTASILHLCCISVDRYYAIVKPLKY 261

  Fly   484 AKHKNSRRVCLTILLVWAISAAIGS--PIVLGLNNTPNRE------PDVCAF-YNADFILYSSLS 539
            ......|.|.:.:|..| ||.|:.|  ||.:|...||..:      |..|:| .|..:.:.||..
  Fly   262 PISMTKRVVGIMLLNTW-ISPALLSFLPIFIGWYTTPQHQQFVIQNPTQCSFVVNKYYAVISSSI 325

  Fly   540 SFYIPCIIMVFLYWNIFKALRSRARKQRAARKPHLSELTGGSVIENIAQTRRLAETALDSSRHAS 604
            ||:|||.||:|.|..||:. .:|..||...|.
  Fly   326 SFWIPCTIMIFTYLAIFRE-ANRQEKQLMMRH--------------------------------- 356

  Fly   605 RILPDEAATNTASGSNEEEDENAISPDIDDCHVIVNDKSTEFMLATVVEETGNSVVAQITTQPQL 669
                                                               ||   |.:..:|.:
  Fly   357 ---------------------------------------------------GN---AMLMHRPSM 367

  Fly   670 VVADPNGNHDSGYAASNVDDVLAGVAPASASAATSAAPRSSGSPPDSPLPSGATLQRSSVSSQRR 734
               .|:|...||                            ||        |..||....|..:..
  Fly   368 ---QPSGEALSG----------------------------SG--------SSKTLTLHEVEQEHT 393

  Fly   735 PTGDDSPKRGEPALRSVGVDNSSVAMKPLSFVRYGVQEAMTLARNDSTLSTTSKTSSRKDKKNSQ 799
            ||                                                        |||.
  Fly   394 PT--------------------------------------------------------KDKH--- 399

  Fly   800 ASRFTIYKVHKASKKKREKSSAKKERKATKTLAIVLGVFLFCWLPFFSCNIMDAMCAKFKKDCRP 864
                 :.|:             |:|.||.:||.|::|.|:.||||||....:...|    ::|:.
  Fly   400 -----LIKM-------------KREHKAARTLGIIMGTFILCWLPFFLWYTLSMTC----EECQV 442

  Fly   865 GLTAYMMTTWLGYINSFVNPVIYTIFNPEFRKAFKKIM 902
            ......:..|:||.||.:||:||..||.:||:||:..:
  Fly   443 PDIVVSILFWIGYFNSTLNPLIYAYFNRDFREAFRNTL 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dop2R	NP_001014758.2	7tmA_D2-like_dopamine_R	376..>565	CDD:320181	80/200 (40%)
		TM helix 1	377..403	CDD:320181	11/28 (39%)
		TM helix 2	410..436	CDD:320181	14/25 (56%)
		TM helix 3	448..478	CDD:320181	15/29 (52%)
		TM helix 4	490..513	CDD:320181	10/24 (42%)
		TM helix 5	529..558	CDD:320181	14/28 (50%)
		7tm_GPCRs	<822..898	CDD:333717	30/75 (40%)
		TM helix 6	825..850	CDD:320095	13/24 (54%)
		TM helix 7	866..891	CDD:320095	9/24 (38%)
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	74/178 (42%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	123/503 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010