DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dop2R and Drd3

DIOPT Version :9

Sequence 1:	NP_001014758.2	Gene:	Dop2R / 33007	FlyBaseID:	FBgn0053517	Length:	905	Species:	Drosophila melanogaster
Sequence 2:	NP_058836.1	Gene:	Drd3 / 29238	RGDID:	2521	Length:	446	Species:	Rattus norvegicus

Alignment Length:	568	Identity:	173/568 - (30%)
Similarity:	246/568 - (43%)	Gaps:	158/568 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   358 NETLNLTDSCGELRVVDHNYWALILILFPILTLFGNILVILSVCRERSLQTVTNYFIVSLAIADL 422
            |.|....:|.|..|...|.|:||......:..:|||.||..:|.|||:|||.|||.:||||:|||
  Rat    12 NSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADL 76

  Fly   423 LVAVVVMPFAVYF-LVNGAWALPDVVCDFYIAMDVICSTSSIFNLVAISIDRYIAVTQPIKYAKH 486
            |||.:|||:.||. :..|.|....:.||.::.:||:..|:||.||.|||||||.||..|:.| :|
  Rat    77 LVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHY-QH 140

  Fly   487 ----KNSRRVCLTILLVWAISAAIGSPIVLGLNNTPNREPDVCAFYNADFILYSSLSSFYIPCII 547
                .:.|||.|.|..||.::.|:..|::.|.|.|  .:|.:|:..|.||::|||:.|||:|..:
  Rat   141 GTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTT--GDPSICSISNPDFVIYSSVVSFYVPFGV 203

  Fly   548 MVFLYWNIFKALRSRARKQRAAR--------KPHLSELTGGSVIENIAQTRRLAETALDSSRHAS 604
            .|.:|..|:..||.|.||:...|        :|...:.:....:..|.|.         |.|  :
  Rat   204 TVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQF---------SIR--A 257

  Fly   605 RILPDEAATNTASGSNEEEDENAISPDIDDCHVIVNDKSTEFMLATVVEETGNSVVAQITTQPQL 669
            |.|.|      |:|..|              |:
  Rat   258 RFLSD------ATGQME--------------HI-------------------------------- 270

  Fly   670 VVADPNGNHDSGYAASNVDDVLAGVAPASASAATSAAPRSSGSPPDSPLPSGATLQRSSVSSQRR 734
                    .|..|.....|.:|                  |...|.||..:...|:|.....|
  Rat   271 --------EDKQYPQKCQDPLL------------------SHLQPPSPGQTHGGLKRYYSICQ-- 307

  Fly   735 PTGDDSPKRGEPALRSVGVDNSSVAMKPLSFVRYGVQEAMTLARNDSTLSTTSKTSSRKDKKNSQ 799
                      :.|||...::..: .|.|:.             |..::||.|            .
  Rat   308 ----------DTALRHPSLEGGA-GMSPVE-------------RTRNSLSPT------------M 336

  Fly   800 ASRFTIYKVHKASKKK----------REKSSAKKERKATKTLAIVLGVFLFCWLPFFSCNIMDAM 854
            |.:.:: :|.|.|..:          :.:....:|:|||:.:.||||.|:.||||||..::::..
  Rat   337 APKLSL-EVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTH 400

  Fly   855 CAKFKKDCRPGLTAYMMTTWLGYINSFVNPVIYTIFNPEFRKAFKKIM 902
            |    :.|......|..||||||:||.:||||||.||.||||||.||:
  Rat   401 C----QACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKIL 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dop2R	NP_001014758.2	7tmA_D2-like_dopamine_R	376..>565	CDD:320181	86/193 (45%)
		TM helix 1	377..403	CDD:320181	9/25 (36%)
		TM helix 2	410..436	CDD:320181	18/26 (69%)
		TM helix 3	448..478	CDD:320181	17/29 (59%)
		TM helix 4	490..513	CDD:320181	9/22 (41%)
		TM helix 5	529..558	CDD:320181	13/28 (46%)
		7tm_GPCRs	<822..898	CDD:333717	38/75 (51%)
		TM helix 6	825..850	CDD:320095	14/24 (58%)
		TM helix 7	866..891	CDD:320095	15/24 (63%)
Drd3	NP_058836.1	7tm_4	44..>225	CDD:304433	85/183 (46%)
Drd3	NP_058836.1	7tm_1	46..429	CDD:278431	150/517 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	249	1.000	Domainoid score	I2060
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	287	1.000	Inparanoid score	I2754
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003003
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24248
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1733
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.060