Protein Alignment Dop2R and drd2a

DIOPT Version :9

• Sequence 1: NP_001014758.2
• Gene: Dop2R / 33007
• FlyBaseID: FBgn0053517
• Length: 905
• Species: Drosophila melanogaster
• Sequence 2: NP_898891.1
• Gene: drd2a / 282557
• ZFINID: ZDB-GENE-021119-2
• Length: 448
• Species: Danio rerio
• Alignment Length: 555
• Identity: 183/555 - (32%)
• Similarity: 256/555 - (46%)
• Gaps: 142/555 - (25%)

  Fly   362 NLTDSCGELRVVDHNYWALILILFPILTLFGNILVILSVCRERSLQTVTNYFIVSLAIADLLVAV 426
            |.|:..|..:   :||:|::|.|...:.:|||:||.::|.||::|||.|||.|||||:||||||.
Zfish    22 NATEQGGRHQ---YNYYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVAT 83

  Fly   427 VVMPFAVYFLVNGAWALPDVVCDFYIAMDVICSTSSIFNLVAISIDRYIAVTQPIKY-AKHKNSR 490
            :|||:.||..|.|.|....:.||.::.:||:..|:||.||.|||||||.||..|:.| .::.:.|
Zfish    84 LVMPWVVYLEVVGEWRFSTIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKR 148

  Fly   491 RVCLTILLVWAISAAIGSPIVLGLNNTPNREPDVCAFYNADFILYSSLSSFYIPCIIMVFLYWNI 555
            ||.:.|.:||.:|.||..|::.|||||...:..:|...|..|::|||:.|||:|.||.:.:|..|
Zfish   149 RVTVMISVVWILSFAISCPLLFGLNNTVTHDDALCVIANPAFVVYSSIVSFYVPFIITLLVYVQI 213

  Fly   556 FKALRSRARKQRAARKPHLSELTGGSVIENIAQTRRLAETALDSSRHASRILPDEAATNTASGSN 620
            :..||.|.::....|...::::...|.|:....                   ||
Zfish   214 YVVLRKRRKRVNTKRTCPVTDMDMSSTIKKCTH-------------------PD----------- 248

  Fly   621 EEEDENAISPDIDDCHVI--------VNDKSTEFMLATVVEETGNSVVAQITTQPQLVVADPNGN 677
                      |:..|.||        ||:|:..|:...|
Zfish   249 ----------DVKLCTVIVKSSGNCPVNNKNVIFIKEVV-------------------------- 277

  Fly   678 HDSGYAASNVDDVLAGVAPASASAATSAAPRSSGSPPDSPLPSGATLQRSSVSSQRRPTGDDSPK 742
                   :|.||:..........:......:|.||..:|.|          |:|..|.| |.||.
Zfish   278 -------NNGDDIQMDEITNRNPSRQRKQDQSGGSQQNSRL----------VNSNLRET-DISPP 324

  Fly   743 RGEPALRSVGVDNSSVAMKPLSFVRYGVQEAMTLARNDSTLSTTSKTSSRKDKKNSQASRFTIYK 807
            ..|            ..:||              .||.:|.|.|         |.::|....:..
Zfish   325 SPE------------AGVKP--------------ERNGNTSSIT---------KGAKAFEIQVSP 354

  Fly   808 VHKASKK----KREKSSAKKERKATKTLAIVLGVFLFCWLPFFSCNIMDAMCAKFKKDCRPGLTA 868
            ..|....    .:.|.|.:||:|||:.||||||||:.||||||..:|::..|     ...|.|
Zfish   355 TGKTQTSVKTLNKRKISQQKEKKATQMLAIVLGVFIICWLPFFITHIVNTYC-----QVPPEL-- 412

  Fly   869 YMMTTWLGYINSFVNPVIYTIFNPEFRKAFKKIMH 903
            |...|||||:||.|||:|||.||.||||||.||:|
Zfish   413 YTAFTWLGYVNSAVNPIIYTTFNIEFRKAFIKILH 447

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop2R	NP_001014758.2	7tmA_D2-like_dopamine_R	376..>565	CDD:320181	90/189 (48%)
		TM helix 1	377..403	CDD:320181	10/25 (40%)
		TM helix 2	410..436	CDD:320181	19/25 (76%)
		TM helix 3	448..478	CDD:320181	17/29 (59%)
		TM helix 4	490..513	CDD:320181	10/22 (45%)
		TM helix 5	529..558	CDD:320181	13/28 (46%)
		7tm_GPCRs	<822..898	CDD:333717	43/75 (57%)
		TM helix 6	825..850	CDD:320095	17/24 (71%)
		TM helix 7	866..891	CDD:320095	15/24 (63%)
drd2a	NP_898891.1	7tm_4	34..>228	CDD:304433	89/193 (46%)
		7tm_1	49..431	CDD:278431	160/507 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	290	1.000	Inparanoid score	I2779
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003003
OrthoInspector	1	1.000	-	-		otm24623
orthoMCL	1	0.900	-	-		OOG6_108090
Panther	1	1.100	-	-	O	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1733
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.960