Protein Alignment Dop2R and drd3

DIOPT Version :9

• Sequence 1: NP_001014758.2
• Gene: Dop2R / 33007
• FlyBaseID: FBgn0053517
• Length: 905
• Species: Drosophila melanogaster
• Sequence 2: XP_005162730.1
• Gene: drd3 / 282554
• ZFINID: ZDB-GENE-021119-1
• Length: 472
• Species: Danio rerio
• Alignment Length: 529
• Identity: 178/529 - (33%)
• Similarity: 250/529 - (47%)
• Gaps: 114/529 - (21%)

  Fly   376 NYWALILILFPILTLFGNILVILSVCRERSLQTVTNYFIVSLAIADLLVAVVVMPFAVYF-LVNG 439
            ||:|::..|..:..:|||:||.::|.|||:|||.|||.:||||:||||||.:|||:|||. :|.|
Zfish    54 NYYAMLYSLLILAIVFGNVLVCIAVLRERALQTTTNYLVVSLAVADLLVASLVMPWAVYLEVVGG 118

  Fly   440 AWALPDVVCDFYIAMDVICSTSSIFNLVAISIDRYIAVTQPIKY-AKHKNSRRVCLTILLVWAIS 503
            ||....:.|:.::.:||:..|:||.||.|||||||.||..|:.| ..|.:.:||.:.|..||.::
Zfish   119 AWLFSRLYCNVFVTLDVMMCTASILNLCAISIDRYTAVVMPVLYNTTHSSRKRVSVMIATVWVLA 183

  Fly   504 AAIGSPIVLGLNNTPNREPDVCAFYNADFILYSSLSSFYIPCIIMVFLYWNIFKALRSRARKQRA 568
            .|:..|::.|.|.|.  :|.||:..|.||::|||:.|||:|..:.:.:|..|:..|| |.||:..
Zfish   184 FAVSCPLLFGFNTTD--DPAVCSISNPDFVIYSSVVSFYLPFAVTLLVYVRIYIFLR-RRRKKIT 245

  Fly   569 ARKPHLSELTGGSVIENIAQTRRLAETALDSSRHASRILPDEAATNTASGSNEEEDENAISPDID 633
            .|:        ||.....|......|..|....|                 .|:.|   :||
Zfish   246 FRQ--------GSGKVQPASAPPSVEMCLQDDAH-----------------KEKRD---LSP--- 279

  Fly   634 DCHVIVNDKSTEFMLATVVEETGNSVVAQITTQPQLVVADPNGNHDSGYAASNVDDVLAGVAPAS 698
               :.:|          |:.|:...|:     :|:|:.                 :.|....|.:
Zfish   280 ---IRIN----------VITESKEQVI-----RPRLLA-----------------NCLRRKRPQT 309

  Fly   699 ASAATSAAPRSSGSPPDSPLPSGATLQRSSVSSQRRPTGDDSPKRGEPALRSVGVDNSSVAMKPL 763
            |.|..|.            ||...||...|:|.......:....|.|    ..|.|...||::..
Zfish   310 APAENSL------------LPPVITLNYCSISQASFARTEQDANREE----EEGGDEEQVAVRSC 358

  Fly   764 SFVRYGVQEAMTLARNDSTLSTTSKTSSRKDKKNSQASRFTIYKVHKASKKKREKSSAKKERKAT 828
                    |...||...:..|.....::......|||               |.:|...||:|||
Zfish   359 --------EVKKLANGRTHTSLRPPRAAHAMVCPSQA---------------RCRSMHSKEKKAT 400

  Fly   829 KTLAIVLGVFLFCWLPFFSCNIMDAMCAKFKKDCRPGLTAYMMTTWLGYINSFVNPVIYTIFNPE 893
            :.|||||||||.||||||..:|::..|    :.|......|...|||||:||.:||||||.||.|
Zfish   401 QMLAIVLGVFLICWLPFFVTHILNTHC----RACHIPPEVYSAFTWLGYVNSALNPVIYTTFNIE 461

  Fly   894 FRKAFKKIM 902
            ||:||.||:
Zfish   462 FRRAFIKIL 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop2R	NP_001014758.2	7tmA_D2-like_dopamine_R	376..>565	CDD:320181	87/190 (46%)
		TM helix 1	377..403	CDD:320181	9/25 (36%)
		TM helix 2	410..436	CDD:320181	19/26 (73%)
		TM helix 3	448..478	CDD:320181	16/29 (55%)
		TM helix 4	490..513	CDD:320181	7/22 (32%)
		TM helix 5	529..558	CDD:320181	12/28 (43%)
		7tm_GPCRs	<822..898	CDD:333717	42/75 (56%)
		TM helix 6	825..850	CDD:320095	18/24 (75%)
		TM helix 7	866..891	CDD:320095	14/24 (58%)
drd3	XP_005162730.1	7tm_4	68..>243	CDD:304433	84/177 (47%)
		7tm_1	70..455	CDD:278431	161/496 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	290	1.000	Inparanoid score	I2779
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003003
OrthoInspector	1	1.000	-	-		otm24623
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1733
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	7.060