DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dop2R and Adora2a

DIOPT Version :10

Sequence 1:NP_001014758.2 Gene:Dop2R / 33007 FlyBaseID:FBgn0053517 Length:905 Species:Drosophila melanogaster
Sequence 2:NP_445746.3 Gene:Adora2a / 25369 RGDID:2049 Length:410 Species:Rattus norvegicus


Alignment Length:537 Identity:106/537 - (19%)
Similarity:164/537 - (30%) Gaps:274/537 - (51%)


- Green bases have known domain annotations that are detailed below.


  Fly   387 ILTLFGNILVILSVCRERSLQTVTNYFIVSLAIADLLVAVVVMPFAVYFLVNGAWALPDVVCDFY 451
            :|.:.||:||..:|....:||.|||:|:||||.||:.|.|:.:|||:  .::..:......|.|:
  Rat    15 VLAILGNVLVCWAVWINSNLQNVTNFFVVSLAAADIAVGVLAIPFAI--TISTGFCAACHGCLFF 77

  Fly   452 IAMDVICSTSSIFNLVAISIDRYIAVTQPIKYAKHKNSRRVCLTILLVWAISAAIGSPIVLGLNN 516
            ....::.:.||||:|:||:||||||:..|::|.......|....|.:.|.:|.|||...:||.||
  Rat    78 ACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGVRAKGIIAICWVLSFAIGLTPMLGWNN 142

  Fly   517 TPNREPD----------VCAFYNA---DFILYSSLSSF-YIPCIIMVFLYWNIFKALRSRARKQR 567
            ...::.:          .|.|.:.   ::::|.:..:| .:|.::|:.:|..||.|    ||:| 
  Rat   143 CSQKDGNSTKTCGEGRVTCLFEDVVPMNYMVYYNFFAFVLLPLLLMLAIYLRIFLA----ARRQ- 202

  Fly   568 AARKPHLSELTGGSVIENIAQTRRLAETALDSSRHASRILPDEAATNTASGSNEEEDENAISPDI 632
                                                                             
  Rat   203 ----------------------------------------------------------------- 202

  Fly   633 DDCHVIVNDKSTEFMLATVVEETGNSVVAQITTQPQLVVADPNGNHDSGYAASNVDDVLAGVAPA 697
                                       :.|:.:|                               
  Rat   203 ---------------------------LKQMESQ------------------------------- 209

  Fly   698 SASAATSAAPRSSGSPPDSPLPSGATLQRSSVSSQRRPTGDDSPKRGEPALRSVGVDNSSVAMKP 762
                               |||                        ||                 
  Rat   210 -------------------PLP------------------------GE----------------- 214

  Fly   763 LSFVRYGVQEAMTLARNDSTLSTTSKTSSRKDKKNSQASRFTIYKVHKASKKKREKSSAKKERKA 827
                                                                 |.:|:.:||..|
  Rat   215 -----------------------------------------------------RTRSTLQKEVHA 226

  Fly   828 TKTLAIVLGVFLFCWLPFFSCNIMDAMCAKFKKDCRPGLTAYMMTTWLGYI-------NSFVNPV 885
            .|:|||::|:|..||||....|.....|:    .||..      ..||.|:       ||.|||.
  Rat   227 AKSLAIIVGLFALCWLPLHIINCFTFFCS----TCRHA------PPWLMYLAIILSHSNSVVNPF 281

  Fly   886 IYTIFNPEFRKAFKKIM 902
            ||.....|||:.|:||:
  Rat   282 IYAYRIREFRQTFRKII 298

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dop2RNP_001014758.2 7tmA_D2-like_dopamine_R 376..>565 CDD:320181 62/191 (32%)
TM helix 1 377..403 CDD:320181 6/15 (40%)
TM helix 2 410..436 CDD:320181 14/25 (56%)
TM helix 3 448..478 CDD:320181 15/29 (52%)
TM helix 4 490..513 CDD:320181 7/22 (32%)
TM helix 5 529..558 CDD:320181 7/32 (22%)
7tm_GPCRs <822..898 CDD:475119 30/82 (37%)
TM helix 6 828..850 CDD:320181 10/21 (48%)
TM helix 7 866..891 CDD:320181 10/31 (32%)
Adora2aNP_445746.3 7tmA_Adenosine_R_A2A 4..294 CDD:320196 103/531 (19%)
TM helix 1 5..31 CDD:320196 6/15 (40%)
TM helix 2 38..65 CDD:320196 14/28 (50%)
TM helix 3 74..104 CDD:320196 15/29 (52%)
TM helix 4 118..136 CDD:320196 6/17 (35%)
TM helix 5 169..199 CDD:320196 8/33 (24%)
TM helix 6 221..251 CDD:320196 14/29 (48%)
TM helix 7 262..287 CDD:320196 10/24 (42%)
Interaction with GAS2L2. /evidence=ECO:0000269|PubMed:23994616 322..410
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 344..410
Blue background indicates that the domain is not in the aligned region.

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