Protein Alignment Dop2R and Htr4

DIOPT Version :10

• Sequence 1: NP_001014758.2
• Gene: Dop2R / 33007
• FlyBaseID: FBgn0053517
• Length: 905
• Species: Drosophila melanogaster
• Sequence 2: NP_036985.2
• Gene: Htr4 / 25324
• RGDID: 2850
• Length: 388
• Species: Rattus norvegicus
• Alignment Length: 557
• Identity: 121/557 - (21%)
• Similarity: 181/557 - (32%)
• Gaps: 273/557 - (49%)

  Fly   371 RVVDHNYWALILILFPILTLFGNILVILSVCRERSLQTV-TNYFIVSLAIADLLVAVVVMPFAVY 434
            :||...::|:::    ::.:.||:||:::|||:|.|:.: |||||||||.|||||:|:||||...
  Rat    19 KVVLLTFFAMVI----LMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAI 79

  Fly   435 FLVNGAWALPDVVCDFYIAMDVICSTSSIFNLVAISIDRYIAV-TQPIKYAKHKNSRRVCLTILL 498
            .||...|...::.|....::||:.:|:|||:|..||:|||.|: .||:.|.......|:.|.:..
  Rat    80 ELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGG 144

  Fly   499 VWAISAAIG-SPIVLGLNN------------TPNREPDVCAF-YNADFILYSSLSSFYIPCIIMV 549
            .|.|...|. .||:.|.||            ..|.....|.| .|..:.:..|:.:||||.::||
  Rat   145 CWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSNSTFCVFMVNKPYAITCSVVAFYIPFLLMV 209

  Fly   550 FLYWNIFKALRSRARKQRAARKPHLSELTGGSVIENIAQTRRLAETALDSSRHASRILPDEAATN 614
            ..|:.|:                                        :.:..||.:|
  Rat   210 LAYYRIY----------------------------------------VTAKEHAQQI-------- 226

  Fly   615 TASGSNEEEDENAISPDIDDCHVIVNDKSTEFMLATVVEETGNSVVAQITTQPQLVVADPNGNHD 679
                                                                             
  Rat   227 ----------------------------------------------------------------- 226

  Fly   680 SGYAASNVDDVLAGVAPASASAATSAAPRSSGSPPDSPLPSGATLQRSSVSSQRRPTGDDSPKRG 744
                                                      ..|||:..:|:.||...|.
  Rat   227 ------------------------------------------QMLQRAGATSESRPQTADQ---- 245

  Fly   745 EPALRSVGVDNSSVAMKPLSFVRYGVQEAMTLARNDSTLSTTSKTSSRKDKKNSQASRFTIYKVH 809
                                                                         :..|
  Rat   246 -------------------------------------------------------------HSTH 249

  Fly   810 KASKKKREKSSAKKERKATKTLAIVLGVFLFCWLPFFSCNIMDAMCAKFKKDCRPGL-------- 866
            :          .:.|.||.|||.:::|.|.|||.|||..||:|           |.:
  Rat   250 R----------MRTETKAAKTLCVIMGCFCFCWAPFFVTNIVD-----------PFIDYTVPEKV 293

  Fly   867 -TAYMMTTWLGYINSFVNPVIYTIFNPEFRKAFKKIM 902
             ||::   |||||||.:||.:|...|..||:||..|:
  Rat   294 WTAFL---WLGYINSGLNPFLYAFLNKSFRRAFLIIL 327

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop2R	NP_001014758.2	7tmA_D2-like_dopamine_R	376..>565	CDD:320181	72/204 (35%)
		TM helix 1	377..403	CDD:320181	7/25 (28%)
		TM helix 2	410..436	CDD:320181	19/25 (76%)
		TM helix 3	448..478	CDD:320181	14/30 (47%)
		TM helix 4	490..513	CDD:320181	7/23 (30%)
		TM helix 5	529..558	CDD:320181	10/28 (36%)
		7tm_GPCRs	<822..898	CDD:475119	33/84 (39%)
		TM helix 6	828..850	CDD:320181	11/21 (52%)
		TM helix 7	866..891	CDD:320181	12/33 (36%)
Htr4	NP_036985.2	7tmA_5-HT4	20..323	CDD:320184	118/550 (21%)
		TM helix 1	21..47	CDD:320184	8/29 (28%)
		TM helix 2	55..81	CDD:320184	19/25 (76%)
		TM helix 3	93..123	CDD:320184	14/29 (48%)
		TM helix 4	136..159	CDD:320184	7/22 (32%)
		TM helix 5	189..218	CDD:320184	10/68 (15%)
		TM helix 6	252..282	CDD:320184	16/29 (55%)
		TM helix 7	291..316	CDD:320184	12/27 (44%)