DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dop2R and Drd2

DIOPT Version :9

Sequence 1:NP_001014758.2 Gene:Dop2R / 33007 FlyBaseID:FBgn0053517 Length:905 Species:Drosophila melanogaster
Sequence 2:NP_036679.1 Gene:Drd2 / 24318 RGDID:2520 Length:444 Species:Rattus norvegicus


Alignment Length:536 Identity:174/536 - (32%)
Similarity:244/536 - (45%) Gaps:133/536 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   375 HNYWALILILFPILTLFGNILVILSVCRERSLQTVTNYFIVSLAIADLLVAVVVMPFAVYFLVNG 439
            :||:|::|.|...:.:|||:||.::|.||::|||.|||.|||||:||||||.:|||:.||..|.|
  Rat    34 YNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVG 98

  Fly   440 AWALPDVVCDFYIAMDVICSTSSIFNLVAISIDRYIAVTQPIKY-AKHKNSRRVCLTILLVWAIS 503
            .|....:.||.::.:||:..|:||.||.|||||||.||..|:.| .::.:.|||.:.|.:||.:|
  Rat    99 EWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLS 163

  Fly   504 AAIGSPIVLGLNNTPNREPDVCAFYNADFILYSSLSSFYIPCIIMVFLYWNIFKALRSRARKQRA 568
            ..|..|::.|||||...|   |...|..|::|||:.|||:|.|:.:.:|..|:..||.|.::   
  Rat   164 FTISCPLLFGLNNTDQNE---CIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKR--- 222

  Fly   569 ARKPHLSELTGGSVIENIAQTRRLAETALDSSRHASRILPDEAATNTASGSNEEEDENAISPDID 633
                              ..|:|           :||.......|.........||         
  Rat   223 ------------------VNTKR-----------SSRAFRANLKTPLKGNCTHPED--------- 249

  Fly   634 DCHVIVNDKSTEFMLATVVEETGNSVVAQITTQPQLVVADPNGNHDSGYAASNVD-DVLAGVAPA 697
                        ..|.||:.::..|....            ....|:...|..:: ::|      
  Rat   250 ------------MKLCTVIMKSNGSFPVN------------RRRMDAARRAQELEMEML------ 284

  Fly   698 SASAATSAAPRSSGSPPD----SPL-PSGATLQRSSVSSQRRPTGDDSPKRGEPALRSVGVDNSS 757
                       ||.|||:    ||: ||...|.....|.....:..|||.:.|        .|..
  Rat   285 -----------SSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPE--------KNGH 330

  Fly   758 VAMKPLSFVRYGVQEAMTLARNDSTLSTTSKTSSRKDKKNSQASRFTIYKVHKASKKKREKSSAK 822
            ..:......::...:.|...:..::|.|.|                            |.|.|.:
  Rat   331 AKIVNPRIAKFFEIQTMPNGKTRTSLKTMS----------------------------RRKLSQQ 367

  Fly   823 KERKATKTLAIVLGVFLFCWLPFFSCNIMDAMCAKFKKDCRPGLTAYMMTTWLGYINSFVNPVIY 887
            ||:|||:.||||||||:.||||||..:|::..|     ||......|...|||||:||.|||:||
  Rat   368 KEKKATQMLAIVLGVFIICWLPFFITHILNIHC-----DCNIPPVLYSAFTWLGYVNSAVNPIIY 427

  Fly   888 TIFNPEFRKAFKKIMH 903
            |.||.||||||.||:|
  Rat   428 TTFNIEFRKAFMKILH 443

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dop2RNP_001014758.2 7tmA_D2-like_dopamine_R 376..>565 CDD:320181 89/189 (47%)
TM helix 1 377..403 CDD:320181 10/25 (40%)
TM helix 2 410..436 CDD:320181 19/25 (76%)
TM helix 3 448..478 CDD:320181 17/29 (59%)
TM helix 4 490..513 CDD:320181 9/22 (41%)
TM helix 5 529..558 CDD:320181 12/28 (43%)
7tm_GPCRs <822..898 CDD:333717 43/75 (57%)
TM helix 6 825..850 CDD:320095 17/24 (71%)
TM helix 7 866..891 CDD:320095 14/24 (58%)
Drd2NP_036679.1 7tmA_D2_dopamine_R 35..438 CDD:320435 169/528 (32%)
TM helix 1 37..61 CDD:320435 9/23 (39%)
TM helix 2 70..92 CDD:320435 16/21 (76%)
TM helix 3 108..130 CDD:320435 10/21 (48%)
TM helix 4 154..170 CDD:320435 5/15 (33%)
TM helix 5 187..210 CDD:320435 9/22 (41%)
Interaction with PPP1R9B. /evidence=ECO:0000269|PubMed:10391935 211..374 45/280 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 282..329 16/71 (23%)
TM helix 6 373..395 CDD:320435 15/21 (71%)
TM helix 7 406..431 CDD:320435 14/24 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 249 1.000 Domainoid score I2060
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 287 1.000 Inparanoid score I2754
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003003
OrthoInspector 1 1.000 - - oto98728
orthoMCL 1 0.900 - - OOG6_108090
Panther 1 1.100 - - O PTHR24248
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X1733
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
109.960

Return to query results.
Submit another query.