Protein Alignment Dop2R and Taar8a

DIOPT Version :10

• Sequence 1: NP_001014758.2
• Gene: Dop2R / 33007
• FlyBaseID: FBgn0053517
• Length: 905
• Species: Drosophila melanogaster
• Sequence 2: NP_001010830.1
• Gene: Taar8a / 215859
• MGIID: 2685076
• Length: 344
• Species: Mus musculus
• Alignment Length: 534
• Identity: 113/534 - (21%)
• Similarity: 159/534 - (29%)
• Gaps: 267/534 - (50%)

  Fly   387 ILTLFGNILVILSVCRERSLQTVTNYFIVSLAIADLLVAVVVMPFAVYFLVNGAWALPDVVCDFY 451
            :|.:.||:||::||...:.|.:..|:.|.|||.||.||.:.||||::...:...|...|..|..:
Mouse    43 VLAVCGNLLVVISVLHFKQLHSPANFLIASLASADFLVGISVMPFSMVRSIESCWYFGDAFCSLH 107

  Fly   452 IAMDVICSTSSIFNLVAISIDRYIAVTQPIKY-AKHKNS-RRVCLTIL----LVWA-------IS 503
            ...||....||:.:|..||:|||||||.|:.| .|...| ..:|::|.    ||::       ||
Mouse   108 SCCDVAFCYSSVLHLCFISVDRYIAVTDPLVYPTKFTVSVSGICISISWILPLVYSSAVFYTGIS 172

  Fly   504 AAIGSPIVLGLNNTPNREPDVCA-----FYNADFILYSSLSSFYIPCIIMVFLYWNIFKALRSRA 563
            |.....:|..||         |.     ..|.||:|.|.| .|:||.::|:.||..||...:.:|
Mouse   173 AKGIESLVSALN---------CVGGCQIVINQDFVLISFL-LFFIPTLVMIILYSKIFLVAKQQA 227

  Fly   564 RKQRAARKPHLSELTGGSVIENIAQTRRLAETALDSSRHASRILPDEAATNTASGSNEEEDENAI 628
            .|                           .||::
Mouse   228 VK---------------------------IETSV------------------------------- 234

  Fly   629 SPDIDDCHVIVNDKSTEFMLATVVEETGNSVVAQITTQPQLVVADPNGNHDSGYAASNVDDVLAG 693
                                                          :||
Mouse   235 ----------------------------------------------SGN---------------- 237

  Fly   694 VAPASASAATSAAPRSSGSPPDSPLPSGATLQRSSVSSQRRPTGDDSPKRGEPALRSVGVDNSSV 758
                                                             |||.:..|
Mouse   238 -------------------------------------------------RGESSSES-------- 245

  Fly   759 AMKPLSFVRYGVQEAMTLARNDSTLSTTSKTSSRKDKKNSQASRFTIYKVHKASKKKREKSSAKK 823
                                                              |||       ..||:
Mouse   246 --------------------------------------------------HKA-------RVAKR 253

  Fly   824 ERKATKTLAIVLGVFLFCWLPFFSCNIMDAMCAKFKKDCRPGLTAYMMTTWLGYINSFVNPVIYT 888
            ||||.|||.:.:..|:..|||:    .:||:...|.....|.. .|.:..|..|.||.:||:||.
Mouse   254 ERKAAKTLGVTVVAFMVSWLPY----TIDALVDAFMGFITPAY-VYEICCWGTYYNSAMNPLIYA 313

  Fly   889 IFNPEFRKAFKKIM 902
            .|.|.|:||.|.|:
Mouse   314 FFFPWFKKAIKLIL 327

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop2R	NP_001014758.2	7tmA_D2-like_dopamine_R	376..>565	CDD:320181	68/195 (35%)
		TM helix 1	377..403	CDD:320181	7/15 (47%)
		TM helix 2	410..436	CDD:320181	13/25 (52%)
		TM helix 3	448..478	CDD:320181	13/29 (45%)
		TM helix 4	490..513	CDD:320181	8/33 (24%)
		TM helix 5	529..558	CDD:320181	14/28 (50%)
		7tm_GPCRs	<822..898	CDD:475119	29/75 (39%)
		TM helix 6	828..850	CDD:320181	7/21 (33%)
		TM helix 7	866..891	CDD:320181	9/24 (38%)
Taar8a	NP_001010830.1	7tm_GPCRs	32..323	CDD:475119	110/528 (21%)
		TM helix 1	34..58	CDD:320439	7/14 (50%)
		TM helix 2	67..89	CDD:320439	13/21 (62%)
		TM helix 3	105..127	CDD:320439	6/21 (29%)
		TM helix 4	150..166	CDD:320439	4/15 (27%)
		TM helix 5	194..217	CDD:320439	11/23 (48%)
		TM helix 6	258..280	CDD:320439	8/25 (32%)
		TM helix 7	291..316	CDD:320439	9/25 (36%)