DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dop2R and dop-3

DIOPT Version :9

Sequence 1:	NP_001014758.2	Gene:	Dop2R / 33007	FlyBaseID:	FBgn0053517	Length:	905	Species:	Drosophila melanogaster
Sequence 2:	NP_001024908.2	Gene:	dop-3 / 188499	WormBaseID:	WBGene00020506	Length:	607	Species:	Caenorhabditis elegans

Alignment Length:	629	Identity:	205/629 - (32%)
Similarity:	294/629 - (46%)	Gaps:	118/629 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   362 NLTDSCGELRVVDHNYW----ALILILFPILTLFGNILVILSVCRERSLQTVTNYFIVSLAIADL 422
            ::||....|.||   .|    .:.|.|.|.:.:|||:|||:||.||||||||||..|||||::|.
Worm     7 HVTDIESPLMVV---LWRVAAGVFLPLVPTMAVFGNVLVIMSVFRERSLQTVTNMLIVSLAVSDF 68

  Fly   423 LVAVVVMPFAVYFLVNG-AWALPDVVCDFYIAMDVICSTSSIFNLVAISIDRYIAVTQPIKYAKH 486
            :||:.||.|.||:..|. .|.|....|..|.|:||.|||:||.||:|||:|||||:..||.||::
Worm    69 MVAIGVMSFGVYYEWNDFKWGLGSFFCHVYQALDVACSTASILNLLAISLDRYIAIGHPISYAQY 133

  Fly   487 -KNSRRVCLTILLVWAISAAIGSPIVLGLNNTPNREPDV--CAFYNADFILYSSLSSFYIPCIIM 548
             ....|..::|.:||.:|.|:..|::||:|  |..|.|:  |...|..|.:.||:.||:||||.|
Worm   134 GARGGRAMISITIVWGVSVAVALPLLLGVN--PMEENDLQECELANPYFNMISSIFSFFIPCIAM 196

  Fly   549 VFLYWNIFKALRSRARKQRAARKPHLSE-------LTGGSVIENIAQTRRLAETALDSSRH---- 602
            :.||..||:.||.|.| .|:.|:...||       |.||            |:.|....:|
Worm   197 IILYTIIFRRLRQRER-ARSLRQAQRSENDKISSALLGG------------AQIARQMGKHFKNR 248

  Fly   603 ASRILPDEAATNTAS---GSNEEEDENAISPDIDDCHVIVNDKSTEFMLATVVEETGNSVVAQIT 664
            ..:||. |.:..|:|   .|...||.:.|||.|:..:..:..|       |....|....:.:..
Worm   249 TDQILL-EISFQTSSFPTMSESSEDASTISPMINSFNNFLPKK-------TPYPSTSIPAIPECG 305

  Fly   665 TQPQLVVAD-PNGNHDSGYAASNVDDVLAGVAPASASAATSA--APRSSGSPPDSPLP-----SG 721
            :.|.|.:.: |....:...:..::.|.:..:....:||..::  ..||.|...:..||     :.
Worm   306 SMPNLTIIERPEAEKEKEISIMDLRDTVEMLDDKYSSAILTSFQTSRSFGEELEEILPFIDGSNS 370

  Fly   722 ATLQRSSVSSQRRPTGDDSPKRGEPALRSVGV----DNSSVAMK--PLSFVRYGVQEAMTLARND 780
            ....|..:.:.|..|........:|.|||:.|    |...::.|  .|.|..........|..|.
Worm   371 VKHSREQLHTTRSNTSTTRLLDVKPELRSISVPSIQDEKKLSQKSNDLPFSHQNGTHKQKLLPNP 435

  Fly   781 STLSTTSKTS-------------SRKDKKNSQA-----------SRFTIYK-------------- 807
            ..|..:..|:             :|...|.|.|           ....:||
Worm   436 GILMKSKSTTLLKTNGYMDTDSLNRNSHKKSLADLLANDEFSFSDSMRVYKNRLFKSLSRATSGW 500

  Fly   808 ---------VHKASKKKREKSSAKKERKATKTLAIVLGVFLFCWLPFFSCNIMDAMCAKFKKD-- 861
                     |.||:|:.|      :|.|||.|||:||.||||||||||..::.:::|....::
Worm   501 NKPRPSRHMVKKATKQMR------REHKATVTLAVVLAVFLFCWLPFFVLHLSNSICLIIDENSA 559

  Fly   862 CRPGLTAYMMTTWLGYINSFVNPVIYTIFNPEFRKAFKKIMHMG 905
            |...|..| :.|||||:||.:||:|||:|:..||.||:.|:..|
Worm   560 CVGFLPLY-LATWLGYLNSSLNPLIYTVFDQRFRNAFRNILSCG 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dop2R	NP_001014758.2	7tmA_D2-like_dopamine_R	376..>565	CDD:320181	94/196 (48%)
		TM helix 1	377..403	CDD:320181	12/29 (41%)
		TM helix 2	410..436	CDD:320181	15/25 (60%)
		TM helix 3	448..478	CDD:320181	20/29 (69%)
		TM helix 4	490..513	CDD:320181	7/22 (32%)
		TM helix 5	529..558	CDD:320181	15/28 (54%)
		7tm_GPCRs	<822..898	CDD:333717	38/77 (49%)
		TM helix 6	825..850	CDD:320095	18/24 (75%)
		TM helix 7	866..891	CDD:320095	14/24 (58%)
dop-3	NP_001024908.2	7tm_4	36..>203	CDD:304433	85/168 (51%)
dop-3	NP_001024908.2	7tm_1	38..>204	CDD:278431	84/167 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156081
Domainoid	1	1.000	220	1.000	Domainoid score	I1511
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	246	1.000	Inparanoid score	I2045
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1215361at2759
OrthoFinder	1	1.000	-	-		FOG0003003
OrthoInspector	1	1.000	-	-		oto20610
orthoMCL	1	0.900	-	-		OOG6_108090
Panther	1	1.100	-	-	LDO	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1733
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.900