DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dop2R and ser-1

DIOPT Version :9

Sequence 1:NP_001014758.2 Gene:Dop2R / 33007 FlyBaseID:FBgn0053517 Length:905 Species:Drosophila melanogaster
Sequence 2:NP_001024728.1 Gene:ser-1 / 181716 WormBaseID:WBGene00004776 Length:683 Species:Caenorhabditis elegans


Alignment Length:547 Identity:132/547 - (24%)
Similarity:215/547 - (39%) Gaps:175/547 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   375 HNYWALILILFPILT---LFGNILVILSVCRERSLQTVTNYFIVSLAIADLLVAVVVMPFAVYFL 436
            :::..:.|.|.|:|.   |.||.||.:::..:|.|..|||||:.|||:|||||..:|||.::...
 Worm    52 YHFNGVALFLLPVLCLIGLIGNFLVCVAIATDRRLHNVTNYFLFSLALADLLVCCIVMPLSIVVE 116

  Fly   437 V-NGAWALPDVVCDFYIAMDVICSTSSIFNLVAISIDRYIAVTQPIKYAKHKNSRRVCLTILLVW 500
            | :|.|.....:|..|:..||...::||.::..||:|||:.::||:: .::::...:.:.|.:||
 Worm   117 VRHGVWTWSVSMCLLYVYSDVFLCSASIVHMSVISLDRYLGISQPLR-TRNRSKTLIFIKIAIVW 180

  Fly   501 AISAAIGSPI-VLGLNNTPN-REPDVCAFYNADFILYSSLSSFYIPCIIMVFLYWNIFKALRSRA 563
            .::..:..|| ||.:::|.| ...:.|..::..:|:|.|..:|.||..||...|....:.|..:|
 Worm   181 VVTLLVSCPIAVLAMHDTANILRNNQCMIFSRYYIIYGSTMTFLIPLCIMGVTYAKTTQLLNKQA 245

  Fly   564 R--KQRAARKPHLSELTGGSVIENIAQTRRLAETALDSSRHASRILPDEAATNTASGSNEEEDEN 626
            .  .|:|..|      ..|:.:......|:|......|:              |.:|:       
 Worm   246 SILSQKAGDK------FNGNGLRRTMPHRKLGYARTYSA--------------TVNGT------- 283

  Fly   627 AISPDIDDCHVIVNDKSTEFMLATVVEETGNSVVAQITTQPQLVVADPNGNHDSGYAASNVDDVL 691
                       |.|.|:.                               |.|  |...|::    
 Worm   284 -----------IANGKAI-------------------------------GAH--GRTMSSI---- 300

  Fly   692 AGVAPASASAATSAAPRSSGSPPDSPLPSGATLQRSSVSSQRRPTGDDSPKRGEPALRSVGVDNS 756
                                    |.:.:|.|..|...|              .|::.:.|    
 Worm   301 ------------------------SNIANGETADRLGTS--------------RPSINTNG---- 323

  Fly   757 SVAMKPLSFVRYGVQEAMTLARNDSTLSTTSKTSSRKDKKNSQASRFTIYKVHKASKKKREKSSA 821
                      ...:|:|          ||.:|..||   .::..:.|. .||.:.|..:......
 Worm   324 ----------HKQLQKA----------STINKWKSR---TSNLVTNFA-NKVGRRSSLQTATQDL 364

  Fly   822 KKERKATKTLAIVLGVFLFCWLPFFSCN-----------IMDAMCAKFKKDCRPGLTAYMMTTWL 875
            ..|.|||:.||:|...|..||.|||..|           |.|.:.:.|              .||
 Worm   365 ANEHKATRVLAVVFACFFICWTPFFFINFLIGFGGENVQIPDWVASIF--------------LWL 415

  Fly   876 GYINSFVNPVIYTIFNPEFRKAFKKIM 902
            ||::|.:||:|||:||..||:||.:|:
 Worm   416 GYVSSTINPIIYTVFNKRFRQAFVRIL 442

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dop2RNP_001014758.2 7tmA_D2-like_dopamine_R 376..>565 CDD:320181 64/196 (33%)
TM helix 1 377..403 CDD:320181 9/28 (32%)
TM helix 2 410..436 CDD:320181 15/25 (60%)
TM helix 3 448..478 CDD:320181 11/29 (38%)
TM helix 4 490..513 CDD:320181 6/23 (26%)
TM helix 5 529..558 CDD:320181 9/28 (32%)
7tm_GPCRs <822..898 CDD:333717 31/86 (36%)
TM helix 6 825..850 CDD:320095 13/35 (37%)
TM helix 7 866..891 CDD:320095 10/24 (42%)
ser-1NP_001024728.1 7tmA_5-HT2 56..438 CDD:320180 129/537 (24%)
TM helix 1 57..83 CDD:320180 9/25 (36%)
TM helix 2 90..116 CDD:320180 15/25 (60%)
TM helix 3 129..159 CDD:320180 11/29 (38%)
TM helix 4 170..193 CDD:320180 5/22 (23%)
TM helix 5 211..240 CDD:320180 9/28 (32%)
TM helix 6 365..395 CDD:320180 14/29 (48%)
TM helix 7 406..431 CDD:320180 12/38 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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