Protein Alignment Dop2R and DRD3

DIOPT Version :9

• Sequence 1: NP_001014758.2
• Gene: Dop2R / 33007
• FlyBaseID: FBgn0053517
• Length: 905
• Species: Drosophila melanogaster
• Sequence 2: NP_000787.2
• Gene: DRD3 / 1814
• HGNCID: 3024
• Length: 400
• Species: Homo sapiens
• Alignment Length: 562
• Identity: 166/562 - (29%)
• Similarity: 230/562 - (40%)
• Gaps: 192/562 - (34%)

  Fly   358 NETLNLTDSCGELRVVDHNYWALILILFPILTLFGNILVILSVCRERSLQTVTNYFIVSLAIADL 422
            |.|....:|.|..:...|.|:||......:..:|||.||.::|.:||:|||.|||.:||||:|||
Human    12 NYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADL 76

  Fly   423 LVAVVVMPFAVYF-LVNGAWALPDVVCDFYIAMDVICSTSSIFNLVAISIDRYIAVTQPIKYAKH 486
            |||.:|||:.||. :..|.|....:.||.::.:||:..|:||.||.|||||||.||..|:.| :|
Human    77 LVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHY-QH 140

  Fly   487 ----KNSRRVCLTILLVWAISAAIGSPIVLGLNNTPNREPDVCAFYNADFILYSSLSSFYIPCII 547
                .:.|||.|.|..||.::.|:..|::.|.|.|  .:|.||:..|.||::|||:.|||:|..:
Human   141 GTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTT--GDPTVCSISNPDFVIYSSVVSFYLPFGV 203

  Fly   548 MVFLYWNIFKALRSRARKQRAARKPHLSELTGGSVIENIAQTRRLAETA-LDSSRHASRILPDEA 611
            .|.:|..|:..|:.|.||:...|:    .....||.....|.....:.| |:..|:.|      .
Human   204 TVLVYARIYVVLKQRRRKRILTRQ----NSQCNSVRPGFPQQTLSPDPAHLELKRYYS------I 258

  Fly   612 ATNTASG-----------SNEEEDENAISPDIDDCHVIVNDKSTEFMLATVVEETGNSVVAQITT 665
            ..:||.|           ..||:..|::||.|
Human   259 CQDTALGGPGFQERGGELKREEKTRNSLSPTI--------------------------------- 290

  Fly   666 QPQLVVADPNGNHDSGYAASNVDDVLAGVAPASASAATSAAPRSSGSPPDSPLPSGATLQRSSVS 730
                                                    ||:.|             |:...:|
Human   291 ----------------------------------------APKLS-------------LEVRKLS 302

  Fly   731 SQRRPTGDDSPKRGEPALRSVGVDNSSVAMKPLSFVRYGVQEAMTLARNDSTLSTTSKTSSRKDK 795
            :.|..|   |.|.|....|.|          ||
Human   303 NGRLST---SLKLGPLQPRGV----------PL-------------------------------- 322

  Fly   796 KNSQASRFTIYKVHKASKKKREKSSAKKERKATKTLAIVLGVFLFCWLPFFSCNIMDAMCAKFKK 860
                                       :|:|||:.:|||||.|:.||||||..::::..|    :
Human   323 ---------------------------REKKATQMVAIVLGAFIVCWLPFFLTHVLNTHC----Q 356

  Fly   861 DCRPGLTAYMMTTWLGYINSFVNPVIYTIFNPEFRKAFKKIM 902
            .|......|..||||||:||.:||||||.||.||||||.||:
Human   357 TCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKIL 398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop2R	NP_001014758.2	7tmA_D2-like_dopamine_R	376..>565	CDD:320181	85/193 (44%)
		TM helix 1	377..403	CDD:320181	9/25 (36%)
		TM helix 2	410..436	CDD:320181	18/26 (69%)
		TM helix 3	448..478	CDD:320181	17/29 (59%)
		TM helix 4	490..513	CDD:320181	9/22 (41%)
		TM helix 5	529..558	CDD:320181	13/28 (46%)
		7tm_GPCRs	<822..898	CDD:333717	39/75 (52%)
		TM helix 6	825..850	CDD:320095	15/24 (63%)
		TM helix 7	866..891	CDD:320095	15/24 (63%)
DRD3	NP_000787.2	7tm_4	44..>216	CDD:304433	80/174 (46%)
		7tm_1	46..383	CDD:278431	144/511 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	246	1.000	Domainoid score	I2175
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	282	1.000	Inparanoid score	I2884
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003003
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1733
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	7.060