DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dop2R and dop-2

DIOPT Version :9

Sequence 1:	NP_001014758.2	Gene:	Dop2R / 33007	FlyBaseID:	FBgn0053517	Length:	905	Species:	Drosophila melanogaster
Sequence 2:	NP_001256126.1	Gene:	dop-2 / 179347	WormBaseID:	WBGene00001053	Length:	849	Species:	Caenorhabditis elegans

Alignment Length:	890	Identity:	234/890 - (26%)
Similarity:	343/890 - (38%)	Gaps:	371/890 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   311 PNYNGSTVSGT-STIAPGVAITGSRGSGLLLEQNLTGLYLDGYRLNCTNETLNLTDSCGELRVVD 374
            |:.:.||::.| |||.         |||:.|
Worm    16 PSLDLSTITQTPSTIV---------GSGIPL---------------------------------- 37

  Fly   375 HNYWALILILFPILTLFGNILVILSVCRERSLQTVTNYFIVSLAIADLLVAVVVMPFAVY-FLVN 438
             ||..|.||:.|::||.||:|||:||.|.|:||:..|:.|:.||:||||||::|||:||| ::.|
Worm    38 -NYAGLSLIVIPLITLLGNLLVIISVLRYRALQSAINFLILGLAVADLLVAIIVMPYAVYVYVTN 101

  Fly   439 GAWALPDVVCDFYIAMDVICSTSSIFNLVAISIDRYIAVTQPIKYAKH-KNSRRVCLTILLVWAI 502
            |.|.|.:::||.|:|.||.|||:||..|..||.|||.||:.||:|::. :|.:||...|.::|.:
Worm   102 GDWYLGNLMCDIYMASDVCCSTASILLLAVISFDRYRAVSLPIQYSRQSQNVKRVWTLIAVIWLV 166

  Fly   503 SAAIGSPIVLGLN-NTPNREPDVCAFYNADFILYSSLSSFYIPCIIMVFLYWNIFKALRSRARKQ 566
            |..:.||:|.|:| ..|:..|..|.||||:|.:.||:.||.|||.:::|:|..|..||:.|.:..
Worm   167 SLTLASPMVFGVNVRPPDANPYECRFYNAEFSILSSMISFVIPCFLVLFVYIRIIIALKKREKAA 231

  Fly   567 RAAR-----------KPHLSE----------LTGGSVIENI------AQTRRLAETALDSSRHAS 604
            :..|           :|...|          :..|.|: |:      :.|||:.:  .:..|.|.
Worm   232 KMRREKNTIAHGLTMRPDTGEEQVDEEAAGRIVAGPVV-NVMMAALPSMTRRMRQ--FERHRRAI 293

  Fly   605 RILPDEAATNTASGSNEEEDE----------NAISPDIDDCH-------VIVNDKSTEFMLATVV 652
            .:..||         ..||||          :....|.||.|       |..:...|..||..::
Worm   294 ELAGDE---------EWEEDELDVMDECCGGDDAGDDDDDYHADNGQGVVEASAPRTTSMLRRII 349

  Fly   653 EE----TGNSVVAQITTQPQLVVADPNGNHDSGYAASNVDDVLAGVAPASASAA-----TSAAPR 708
            ..    |.||     |.|.   ||..:|.  ..:.|.|:    :..:|:|:|.|     |||.|:
Worm   350 NAASVGTANS-----TAQS---VASASGM--PAFFAQNI----STTSPSSSSCARTTTTTSAIPK 400

  Fly   709 SSGSPPDSPLP--------SGATLQRSSVS---------------------SQRRPTGDDSP--- 741
            :||   |.|||        ..::..|||:.                     |:|....|||.
Worm   401 ASG---DLPLPMLLNEREFGNSSTPRSSLESLSENVNVITNDFVSENCTTFSRRSSYADDSQPTS 462

  Fly   742 -------------------------------------KRGE-------------------PAL-- 748
                                                 .||.                   ||:
Worm   463 SQTSSGDGRSYSIKGQKRFRNLSRNYSTKHHRKVVKVNRGNSRNNSRTASITNQSDDALIPAIIR 527

  Fly   749 ----------------------------------------------------------------- 748

Worm   528 TISRKSPRLFRRDKTDIKKHSMILANPITEPPKEYRRVSMPIHPTNSQTETETISASRDIENLPT 592

  Fly   749 ----RSVGVDNSSVAMKPLSFVRY------------------------GVQEAMT---------- 775
                ||...:::.:...|..|.::                        .|..|:|
Worm   593 TTISRSTTANSAELLGSPDDFEKFPALITETVLEDVLAETREGCFMQPTVSFALTVREMEGNALN 657

  Fly   776 ----------------------------------LARNDSTLST-TSKT-----------SSRKD 794
                                              |.|.||..:| :|||           .|:|.
Worm   658 NLKGCSVESSRRVSQVDPPLAIQILTRPSLPHLDLQRMDSIGTTCSSKTRADSLRSVDSKGSKKS 722

  Fly   795 KKNSQASRFTIYKV-HKASKKKREKSSAKKERKATKTLAIVLGVFLFCWLPFFSCNIMDAMCAKF 858
            .:|..|.:.....: |:.|.|::...:.:||::|||||.:|:||||.||:|||..||::|:|...
Worm   723 NRNGIAVKLVKRAIKHEHSLKRKVSKAQRKEKRATKTLGVVVGVFLVCWVPFFVINILNAVCILL 787

  Fly   859 KKD-CRPGLTAYMMTTWLGYINSFVNPVIYTIFNPEFRKAFKKIM 902
            .|| |:.|...:...||:||:|||:||:||||||.|||:|||.|:
Worm   788 NKDSCQVGYDLFFYCTWIGYMNSFMNPIIYTIFNTEFRRAFKSII 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dop2R	NP_001014758.2	7tmA_D2-like_dopamine_R	376..>565	CDD:320181	93/191 (49%)
		TM helix 1	377..403	CDD:320181	14/25 (56%)
		TM helix 2	410..436	CDD:320181	16/26 (62%)
		TM helix 3	448..478	CDD:320181	18/29 (62%)
		TM helix 4	490..513	CDD:320181	8/22 (36%)
		TM helix 5	529..558	CDD:320181	13/28 (46%)
		7tm_GPCRs	<822..898	CDD:333717	43/76 (57%)
		TM helix 6	825..850	CDD:320095	15/24 (63%)
		TM helix 7	866..891	CDD:320095	13/24 (54%)
dop-2	NP_001256126.1	7tmA_D2-like_dopamine_R	38..>233	CDD:320181	93/194 (48%)
		TM helix 1	40..64	CDD:320181	13/23 (57%)
		TM helix 2	73..95	CDD:320181	13/21 (62%)
		TM helix 3	112..134	CDD:320181	12/21 (57%)
		TM helix 4	158..174	CDD:320181	4/15 (27%)
		TM helix 5	195..218	CDD:320181	10/22 (45%)
		7tm_GPCRs	<745..828	CDD:421689	43/82 (52%)
		TM helix 6	751..781	CDD:410628	19/29 (66%)
		TM helix 7	796..821	CDD:410628	13/24 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156080
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1215361at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_108090
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1733
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.750