Protein Alignment Dop2R and Htr6

DIOPT Version :10

• Sequence 1: NP_001014758.2
• Gene: Dop2R / 33007
• FlyBaseID: FBgn0053517
• Length: 905
• Species: Drosophila melanogaster
• Sequence 2: NP_067333.1
• Gene: Htr6 / 15565
• MGIID: 1196627
• Length: 440
• Species: Mus musculus
• Alignment Length: 533
• Identity: 122/533 - (22%)
• Similarity: 183/533 - (34%)
• Gaps: 231/533 - (43%)

  Fly   378 W-ALILILFPILTLFGNILVILSVCRERSLQTVTNYFIVSLAIADLLVAVVVMPFAVYFLVNGAW 441
            | |..|.:..:||...|.|:|..:|.:.:|:..:|:|:|||..:||:|.:||||.|:...:.|.|
Mouse    28 WVAAALCVVIVLTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRW 92

  Fly   442 ALPDVVCDFYIAMDVICSTSSIFNLVAISIDRYIAVTQPIKYAKHKNSRRVCLTILLVWAISAAI 506
            .|...:|..:.|.||:|.::||.||..||:|||:.:..|::|.....:.|....||..|:: ||:
Mouse    93 VLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSL-AAL 156

  Fly   507 GS--PIVLG---LNNTPNREPDVCAFY-NADFILYSSLSSFYIPCIIMVFLYWNIFKALRSRARK 565
            .|  |::||   |.......|..|... :..::|.:|..:|::|...:.|.|..|..|    |||
Mouse   157 ASFLPLLLGWHELGKARTSAPGQCRLLASLPYVLVASGVTFFLPSGAICFTYCRILLA----ARK 217

  Fly   566 QRAARKPHLSELTGGSVIENIAQTRRLAETALDSSRHASRILPDEAATNTASGSNEEEDENAISP 630
            |...
Mouse   218 QAVQ------------------------------------------------------------- 221

  Fly   631 DIDDCHVIVNDKSTEFMLATVVEETGNSVVAQITTQPQLVVADPNGNHDSGYAASNVDDVLAGVA 695
                                         ||.:||                           |.|
Mouse   222 -----------------------------VASLTT---------------------------GTA 230

  Fly   696 PASASAATSAAPRSSGSPPDSPLPSGATLQRSSVSSQRRPTGDDSPKRGEPALRSVGVDNSSVAM 760
            .|..:..|...||       :|.|
Mouse   231 TAGQALETLQVPR-------TPRP----------------------------------------- 247

  Fly   761 KPLSFVRYGVQEAMTLARNDSTLSTTSKTSSRKDKKNSQASRFTIYKVHKASKKKREKSSAKKER 825
                    |::.|      ||...||         |:|                       :|..
Mouse   248 --------GMESA------DSRRLTT---------KHS-----------------------RKAL 266

  Fly   826 KATKTLAIVLGVFLFCWLPFFSCNIMDAMCAKFKKDC-RPGLTAYMMTTWLGYINSFVNPVIYTI 889
            ||:.||.|:|.:|...|||||..:|..|:|     || .|||  :.:.|||||.||.:||:||.:
Mouse   267 KASLTLGILLSMFFVTWLPFFVASIAQAVC-----DCISPGL--FDVLTWLGYCNSTMNPIIYPL 324

  Fly   890 FNPEFRKAFKKIM 902
            |..:|::|..:.:
Mouse   325 FMRDFKRALGRFV 337

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop2R	NP_001014758.2	7tmA_D2-like_dopamine_R	376..>565	CDD:320181	64/193 (33%)
		TM helix 1	377..403	CDD:320181	9/25 (36%)
		TM helix 2	410..436	CDD:320181	13/25 (52%)
		TM helix 3	448..478	CDD:320181	14/29 (48%)
		TM helix 4	490..513	CDD:320181	8/24 (33%)
		TM helix 5	529..558	CDD:320181	7/28 (25%)
		7tm_GPCRs	<822..898	CDD:475119	34/76 (45%)
		TM helix 6	828..850	CDD:320181	10/21 (48%)
		TM helix 7	866..891	CDD:320181	12/24 (50%)
Htr6	NP_067333.1	7tmA_5-HT6	29..333	CDD:320182	120/526 (23%)
		TM helix 1	29..54	CDD:320182	8/24 (33%)
		TM helix 2	61..87	CDD:320182	13/25 (52%)
		TM helix 3	99..129	CDD:320182	14/29 (48%)
		TM helix 4	141..164	CDD:320182	8/23 (35%)
		TM helix 5	185..214	CDD:320182	7/28 (25%)
		TM helix 6	263..293	CDD:320182	14/29 (48%)
		TM helix 7	301..326	CDD:320182	14/26 (54%)