DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dop2R and Htr1b

DIOPT Version :10

Sequence 1:NP_001014758.2 Gene:Dop2R / 33007 FlyBaseID:FBgn0053517 Length:905 Species:Drosophila melanogaster
Sequence 2:NP_034612.1 Gene:Htr1b / 15551 MGIID:96274 Length:386 Species:Mus musculus


Alignment Length:565 Identity:142/565 - (25%)
Similarity:219/565 - (38%) Gaps:209/565 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   345 TGLYLDGYRLNCTNETLNLTDSCGELRVVDHNYWALILI----LFPILTLFGNILVILSVCRERS 405
            ||:.|.....||:.:.....||..       ..|.::|:    |..:.|...|..||.:|.|.|.
Mouse    18 TGVPLTNLSHNCSADGYIYQDSIA-------LPWKVLLVALLALITLATTLSNAFVIATVYRTRK 75

  Fly   406 LQTVTNYFIVSLAIADLLVAVVVMPFAVYFLVNGAWALPDVVCDFYIAMDVICSTSSIFNLVAIS 470
            |.|..||.|.|||:.||||:::|||.:..:.|.|.|.|..|||||:::.|:.|.|:||.:|..|:
Mouse    76 LHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIMHLCVIA 140

  Fly   471 IDRYIAVTQPIKYAKHKNSRRVCLTILLVWAISAAIGSPIVLGLNNTPNREPDVCAFYNADFIL- 534
            :|||.|:|..::|:..:..:|..:.|:|||..|.:|..|...........|...| |.|.|.:| 
Mouse   141 LDRYWAITDAVEYSAKRTPKRAAIMIVLVWVFSISISLPPFFWRQAKAEEEMLDC-FVNTDHVLY 204

  Fly   535 --YSSLSSFYIPCIIMVFLYWNIFKALRSRARKQRAARKPHLSELTGGSVIENIAQTRRLAETAL 597
              ||::.:||:|.::::.||..|:...|||..||                               
Mouse   205 TVYSTVGAFYLPTLLLIALYGRIYVEARSRILKQ------------------------------- 238

  Fly   598 DSSRHASRILPDEAATNTASGSNEEEDENAISPDIDDCHVIVNDKSTEFMLATVVEETGNSVVAQ 662
                                           :|:                      :||..:   
Mouse   239 -------------------------------TPN----------------------KTGKRL--- 247

  Fly   663 ITTQPQLVVADPNGNHDSGYAASNVDDVLAGVAPASASAATSAAPRSSGSPPDSPLPSGATLQRS 727
              |:.||:.       ||               |.|.|:.||...|:    ||.|..||:.:.  
Mouse   248 --TRAQLIT-------DS---------------PGSTSSVTSINSRA----PDVPSESGSPVY-- 282

  Fly   728 SVSSQRRPTGDDSPKRGEPALRSVGVDNSSVAMKPLSFVRYGVQEAMTLARNDSTLSTTSKTSSR 792
                                               ::.|:..|.:|:.                 
Mouse   283 -----------------------------------VNQVKVRVSDALL----------------- 295

  Fly   793 KDKKNSQASRFTIYKVHKASKKKREKSSAKKERKATKTLAIVLGVFLFCWLPFFSCNIMDAMCAK 857
                                  :::|..|.:||||||||.|:||.|:.||||||..:::..:|  
Mouse   296 ----------------------EKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPIC-- 336

  Fly   858 FKKDCRPGLTAYMMTTWLGYINSFVNPVIYTIFNPEFRKAFKKIM 902
             |..|...:..:....||||:||.:||:|||:.|.:|::||.|::
Mouse   337 -KDACWFHMAIFDFFNWLGYLNSLINPIIYTMSNEDFKQAFHKLI 380

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dop2RNP_001014758.2 7tmA_D2-like_dopamine_R 376..>565 CDD:320181 72/195 (37%)
TM helix 1 377..403 CDD:320181 8/29 (28%)
TM helix 2 410..436 CDD:320181 13/25 (52%)
TM helix 3 448..478 CDD:320181 14/29 (48%)
TM helix 4 490..513 CDD:320181 8/22 (36%)
TM helix 5 529..558 CDD:320181 11/31 (35%)
7tm_GPCRs <822..898 CDD:475119 34/75 (45%)
TM helix 6 828..850 CDD:320181 14/21 (67%)
TM helix 7 866..891 CDD:320181 11/24 (46%)
Htr1bNP_034612.1 7tmA_5-HT1B_1D 42..376 CDD:320455 132/528 (25%)
TM helix 1 47..73 CDD:320455 7/25 (28%)
TM helix 2 80..106 CDD:320455 13/25 (52%)
TM helix 3 118..148 CDD:320455 14/29 (48%)
DRY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 142..144 1/1 (100%)
TM helix 4 160..183 CDD:320455 8/22 (36%)
TM helix 5 201..230 CDD:320455 9/28 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 255..278 11/41 (27%)
TM helix 6 303..333 CDD:320455 18/29 (62%)
TM helix 7 344..369 CDD:320455 11/24 (46%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 361..365 2/3 (67%)

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