DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dop2R and Drd3

DIOPT Version :9

Sequence 1:	NP_001014758.2	Gene:	Dop2R / 33007	FlyBaseID:	FBgn0053517	Length:	905	Species:	Drosophila melanogaster
Sequence 2:	XP_006521840.1	Gene:	Drd3 / 13490	MGIID:	94925	Length:	478	Species:	Mus musculus

Alignment Length:	610	Identity:	180/610 - (29%)
Similarity:	256/610 - (41%)	Gaps:	162/610 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   319 SGTSTIAPGVAITGSRGSGLLLEQN--------LTGLYLDGYRLNCTNETLNLTDSCGELRVVDH 375
            |||..:...|:....:.||.:||.|        |:.:      .:..|.|....:|.|..|...|
Mouse     3 SGTEALNTTVSRHQKKFSGNILESNSSVWAMAPLSQI------SSHINSTCGAENSTGVNRARPH 61

  Fly   376 NYWALILILFPILTLFGNILVILSVCRERSLQTVTNYFIVSLAIADLLVAVVVMPFAVYF-LVNG 439
            .|:||......:..:|||.||..:|.|||:|||.|||.:||||:||||||.:|||:.||. :..|
Mouse    62 AYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGG 126

  Fly   440 AWALPDVVCDFYIAMDVICSTSSIFNLVAISIDRYIAVTQPIKYAKH----KNSRRVCLTILLVW 500
            .|....:.||.::.:||:..|:||.||.|||||||.||..|:.| :|    .:.|||.|.|..||
Mouse   127 VWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHY-QHGTGQSSCRRVALMITAVW 190

  Fly   501 AISAAIGSPIVLGLNNTPNREPDVCAFYNADFILYSSLSSFYIPCIIMVFLYWNIFKALRSRARK 565
            .::.|:..|::.|.|.|  .:|.:|:..|.||::|||:.|||:|..:.|.:|..|:..||.|.||
Mouse   191 VLAFAVSCPLLFGFNTT--GDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYMVLRQRRRK 253

  Fly   566 QRAAR--------KPHLSELTGGSVIENIAQTRRLAETALDSSRHASRILPDEAATNTASGSNEE 622
            :...|        :|...:.:....:..|.|.         |.|  :|.|.|      |:|..|
Mouse   254 RILTRQNSQCISIRPGFPQQSSCLRLHPIRQF---------SIR--ARFLSD------ATGQME- 300

  Fly   623 EDENAISPDIDDCHVIVNDKSTEFMLATVVEETGNSVVAQITTQPQLVVADPNGNHDSGYAASNV 687
                         |:                                        .|..|.....
Mouse   301 -------------HI----------------------------------------EDKPYPQKCQ 312

  Fly   688 DDVLAGVAPASASAATSAAPRSSGSPPDSPLPSGATLQRSSVSSQRRPT-----GDDSPKRGEPA 747
            |.:|:.:.|.|.........|......|:.|              |.|.     |....:|...:
Mouse   313 DPLLSHLQPLSPGQTHGELKRYYSICQDTAL--------------RHPNFEGGGGMSQVERTRNS 363

  Fly   748 LRSVGVDNSSVAMKPLSFVRYGVQEAMTLARNDSTLSTTSKTSSRKDKKNSQASRFTIYKVHKAS 812
            |........|:.::.||               :..|||:.|..
Mouse   364 LSPTMAPKLSLEVRKLS---------------NGRLSTSLKLG---------------------- 391

  Fly   813 KKKREKSSAKKERKATKTLAIVLGVFLFCWLPFFSCNIMDAMCAKFKKDCRPGLTAYMMTTWLGY 877
             ..:.:....:|:|||:.:.||||.|:.||||||..::::..|    :.|......|..||||||
Mouse   392 -PLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHC----QACHVSPELYRATTWLGY 451

  Fly   878 INSFVNPVIYTIFNPEFRKAFKKIM 902
            :||.:||||||.||.||||||.||:
Mouse   452 VNSALNPVIYTTFNIEFRKAFLKIL 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dop2R	NP_001014758.2	7tmA_D2-like_dopamine_R	376..>565	CDD:320181	86/193 (45%)
		TM helix 1	377..403	CDD:320181	9/25 (36%)
		TM helix 2	410..436	CDD:320181	18/26 (69%)
		TM helix 3	448..478	CDD:320181	17/29 (59%)
		TM helix 4	490..513	CDD:320181	9/22 (41%)
		TM helix 5	529..558	CDD:320181	13/28 (46%)
		7tm_GPCRs	<822..898	CDD:333717	38/75 (51%)
		TM helix 6	825..850	CDD:320095	14/24 (58%)
		TM helix 7	866..891	CDD:320095	15/24 (63%)
Drd3	XP_006521840.1	7tmA_D3_dopamine_R	62..472	CDD:320436	160/539 (30%)
		TM helix 1	64..88	CDD:320436	8/23 (35%)
		TM helix 2	97..119	CDD:320436	15/21 (71%)
		TM helix 3	136..158	CDD:320436	10/21 (48%)
		TM helix 4	184..200	CDD:320436	5/15 (33%)
		TM helix 5	218..241	CDD:320436	10/22 (45%)
		TM helix 6	403..428	CDD:320436	14/24 (58%)
		TM helix 7	440..465	CDD:320436	15/24 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	249	1.000	Domainoid score	I2122
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	287	1.000	Inparanoid score	I2812
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003003
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1733
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.060