Protein Alignment Dop2R and Oct-TyrR

DIOPT Version :10

• Sequence 1: NP_001014758.2
• Gene: Dop2R / 33007
• FlyBaseID: FBgn0053517
• Length: 905
• Species: Drosophila melanogaster
• Sequence 2: XP_061506991.1
• Gene: Oct-TyrR / 1273444
• VectorBaseID: AGAMI1_002266
• Length: 644
• Species: Anopheles gambiae
• Alignment Length: 690
• Identity: 205/690 - (29%)
• Similarity: 302/690 - (43%)
• Gaps: 140/690 - (20%)

  Fly   301 LLLENFNDYFPNYNGSTVSGTSTIAPGVAITGSRGSGLLL--EQNLTGLYLDGYRLNCTNETLNL 363
            ::|:||:.....|:...|..........:.|..|...:||  |.::..:.|.|     ...||.|
Mosquito     3 VILQNFSQPGARYSPDQVPQPPPPPAAPSPTTYRELDILLRHEGSIPAVSLAG-----LTATLGL 62

  Fly   364 TDSCGELRVVDHNY----------------------------------W-----ALILILFPILT 389
             ||.|||  :..||                                  |     ||||.|..|:|
Mosquito    63 -DSNGEL--LGANYGANGSDLSELLDGCPKPDDTLYPTMFGIDLAVPQWEAIGTALILTLIIIIT 124

  Fly   390 LFGNILVILSVCRERSLQTVTNYFIVSLAIADLLVAVVVMPFAVYFLVNGAWALPDVVCDFYIAM 454
            :.|||||||||...:.|:.|.|:||||||:|||.||::|:|..|.:.:.|.|.....||..::..
Mosquito   125 IVGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVAILVLPLNVAYSLLGRWEFGIHVCKMWLTS 189

  Fly   455 DVICSTSSIFNLVAISIDRYIAVTQPIKYAKHKNSRRVCLTILLVWAISAAIGSPIVLGLNNTP- 518
            ||:|.|:||.||.||::|||.|:|.||.||:.:...||...|..||.:|..|.||.::|.|:.|
Mosquito   190 DVLCCTASILNLCAIALDRYWAITDPINYAQKRTLERVLALIAGVWVLSLVISSPPLIGWNDWPE 254

  Fly   519 --NREPDVCAFYNADFILYSSLSSFYIPCIIMVFLYWNIFKALRSRARKQRAARKPH-LSELTGG 580
              :.|.......|..:::||||.||:||..||..:|..|:.|.|.|.|::..|.|.: |:..:.|
Mosquito   255 EFSSEFPCQLTSNQGYVIYSSLGSFFIPLAIMTIVYIEIYIATRRRLRERAQASKINTLASRSIG 319

  Fly   581 SVIENIAQTRRLAETALDSSRHASRILPDEAATNTASGSNEEEDENAISPDIDDCHVIVNDKSTE 645
            .|..|       .|..|.::.|..:            ...::...:..|....|.|.|.:|:.
Mosquito   320 MVAGN-------GEKELTTTHHQQQ------------QQQQQHQHHHQSHHHQDGHAIQHDQE-- 363

  Fly   646 FMLATVVEETGNSVVAQITTQPQLVVADPNGNHDSGYA--ASNVDDVLAGVA------------- 695
                ::..||.|......|.....|:|.....:..|:.  ...:...|.|.|
Mosquito   364 ----SISSETNNHNEQTDTGSGGPVLAGSGKPNKKGHLRFGGYLGRALGGAAGRHRKKQHHRKRP 424

  Fly   696 ---PASAS--------AATSAAPRSSGSPPDSPLPSG----------ATLQRSSVSSQRRPTGD- 738
               ||...        ||::...|...|..|:|..||          |.|..:..|:...|||:
Mosquito   425 GDGPAEEGEDGRPHRLAASALHQREDDSVTDNPDHSGSGDSGGGVGKAPLDAAHPSALLPPTGNC 489

  Fly   739 ---DSPKRGEPALRSVGVDNSSVAMKPLSFVRYGVQEAMTLARNDSTLSTTSKTSSR---KDKKN 797
               .....||||.|: |..|:. ..:.:.| .....|.|.:|   :....|::...|   ..:|.
Mosquito   490 DMTGGSATGEPAPRN-GASNNH-HQREVGF-HESTAELMVVA---AAAPPTTRLGGRLKQSFRKP 548

  Fly   798 SQASRFTIYKVHKASKKKREKSSAKKERKATKTLAIVLGVFLFCWLPFFSCNIMDAMCAKFKKDC 862
            ...::|.         ::::|.|..|||:|.:||.|::|||:.||||||...::...|    ..|
Mosquito   549 GGINQFI---------EEKQKISLSKERRAARTLGIIMGVFVVCWLPFFLMYVILPFC----PSC 600

  Fly   863 RPGLTAYMMTTWLGYINSFVNPVIYTIFNPEFRKAFKKIM 902
            .|........||||||||.:||:||||||.::|:|||:::
Mosquito   601 CPTNKLINFITWLGYINSALNPIIYTIFNLDYRRAFKRLL 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop2R	NP_001014758.2	7tmA_D2-like_dopamine_R	376..>565	CDD:320181	88/230 (38%)
		TM helix 1	377..403	CDD:320181	18/64 (28%)
		TM helix 2	410..436	CDD:320181	15/25 (60%)
		TM helix 3	448..478	CDD:320181	15/29 (52%)
		TM helix 4	490..513	CDD:320181	9/22 (41%)
		TM helix 5	529..558	CDD:320181	13/28 (46%)
		7tm_GPCRs	<822..898	CDD:475119	36/75 (48%)
		TM helix 6	828..850	CDD:320181	12/21 (57%)
		TM helix 7	866..891	CDD:320181	14/24 (58%)
Oct-TyrR	XP_061506991.1	None