Protein Alignment Dop2R and LOC1270903

DIOPT Version :10

• Sequence 1: NP_001014758.2
• Gene: Dop2R / 33007
• FlyBaseID: FBgn0053517
• Length: 905
• Species: Drosophila melanogaster
• Sequence 2: XP_061507704.1
• Gene: LOC1270903 / 1270903
• VectorBaseID: AGAMI1_003020
• Length: 497
• Species: Anopheles gambiae
• Alignment Length: 619
• Identity: 162/619 - (26%)
• Similarity: 270/619 - (43%)
• Gaps: 174/619 - (28%)

  Fly   314 NGSTVSGTSTIAPGVAITGSRGSGL--------LLEQNLTGLYLDGYRLNCTNETLNLTDSCGEL 370
            ||||::.:::|.  :..|.:..:..        |.|..|..::.|.:|   ||.|::.:.||
Mosquito     5 NGSTITTSASII--INYTTALSTTYQELYVNLQLSESGLGTVFDDRHR---TNGTISCSRSC--- 61

  Fly   371 RVVDHNYWALILI----LFPILTLFGNILVILSVCRERSLQTVTNYFIVSLAIADLLVAVVVMPF 431
                .::..|:|:    |..::|:.||.||||||...|.|:||||.|::|||:||.||.:.|||.
Mosquito    62 ----LSWKKLVLVALFCLLIVITVVGNTLVILSVLTTRRLRTVTNCFVMSLAVADWLVGIFVMPP 122

  Fly   432 AVYFLVNGAWALPDVVCDFYIAMDVICSTSSIFNLVAISIDRYIAVTQPIKYAKHKNSRRVC-LT 495
            ||...|..:|.|..::||.:|::||:..|:||.:|.|||:|||:|||:|:.|:|.:.|:|:. |.
Mosquito   123 AVIVFVVESWQLGWILCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSKRRRSKRLALLM 187

  Fly   496 ILLVWAISAAIGSPIVLGLNNTPNR--EPDVCAF-YNADFILYSSLSSFYIPCIIMVFLYWNIFK 557
            |.:||.::.||..|.:||..:...|  :...|.: .|..::::|::.||:||..:|:::|..|..
Mosquito   188 IFVVWLVALAITCPPILGWYDQDRRTLQSYECHYNQNKGYVVFSAMGSFFIPMTVMLYVYSKICC 252

  Fly   558 ALRSRARKQRAARKPHLSELTGGSVIENIAQTRRLAETALDSSRHASRILPDEAATNTASGSNEE 622
            .|.||                          ..|:.:|                          |
Mosquito   253 VLTSR--------------------------QNRMTKT--------------------------E 265

  Fly   623 EDENAISPDIDDCHVIVNDKSTEFMLATVVEETGNSVVAQITTQPQLVVAD-------------P 674
            ..|.....::|:|                        .:...|.|:.:|:.             |
Mosquito   266 ATEKNCDIEVDNC------------------------TSDADTSPRQMVSGAYGGRHALSTSHYP 306

  Fly   675 NGNHDSGYAASNVDDVLAG--VAPASASAATSAAPRSSGSPPDSPLPSGATLQRSSVSSQRRPTG 737
            ||:..:..:...:.:.|:.  ..|..||..|.:..|:..:.......||||.:
Mosquito   307 NGSSSNNTSHQTLYEFLSSNRTTPNVASRGTQSTTRNGSNASGMSKFSGATFE------------ 359

  Fly   738 DDSPKRGEPALRSVGVDNSSVAMKPLSFVRYGVQEAMTLARNDSTLSTTSKTSSRKDKKNSQASR 802
                                  ::|::.|::...: ::|:.:.::..||:.|..|...|     |
Mosquito   360 ----------------------LRPINTVQFSASQ-ISLSESCASNVTTNATKVRLHGK-----R 396

  Fly   803 FTIYKVHKASKKKREKSSAKKERKATKTLAIVLGVFLFCWLPFFSCNIMDAMCAKFKKDCRPGLT 867
            ..|           ..||.|:|.|..:||::|:|.|:.||||||...::    ..|..|......
Mosquito   397 IPI-----------RISSLKRETKTAQTLSMVVGGFIACWLPFFVYYLL----MPFIPDDSKSDD 446

  Fly   868 AYMMTTWLGYINSFVNPVIYTIFNPEFRKAFKKI 901
            .....||||:|||.:||.||..:|.:||.||.::
Mosquito   447 LMEFLTWLGWINSAINPFIYAFYNVDFRVAFWRL 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop2R	NP_001014758.2	7tmA_D2-like_dopamine_R	376..>565	CDD:320181	80/196 (41%)
		TM helix 1	377..403	CDD:320181	12/29 (41%)
		TM helix 2	410..436	CDD:320181	15/25 (60%)
		TM helix 3	448..478	CDD:320181	16/29 (55%)
		TM helix 4	490..513	CDD:320181	8/23 (35%)
		TM helix 5	529..558	CDD:320181	9/28 (32%)
		7tm_GPCRs	<822..898	CDD:475119	30/75 (40%)
		TM helix 6	828..850	CDD:320181	11/21 (52%)
		TM helix 7	866..891	CDD:320181	11/24 (46%)
LOC1270903	XP_061507704.1	None